News and Agenda Archive


Slimme contactlenzen en andere medische gadgets in je lijf

Onderzoekers van de technische universiteit van Ulsan in Zuid-Korea zeggen een lens te hebben ontwikkeld die bloedsuikerwaarden uitmeet. Over deze lens en andere bio-elektronische medicijnen praten we met Wouter Serdijn. Hij is hoogleraar bio-elektronica aan de TU Delft. Item op NPO Radio 1, Nieuwsweekend, zaterdag 27 januari 2018.

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Grant for the development of smart cathethers & implants

Ronald Dekker, Vasiliki Giagka, Paul de Wit, Wouter Serdijn and Lina Sarro received a grant concerning the development of smart catheters and implants. The project is financed by ECSEL Innovation actions, Call 2017.

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Electrical Implants -- small devices with huge potential

Since the introduction of the pacemaker in 1958, much has changed in the world of electrical stimulation. Whereas the first electrical implants targeted muscles, the implants of today are flexible and focus mainly on the nerves in our body. The concept, however, remains unchanged: electrical implants give control back to the body. Vasiliki Giagka, Assistant Professor of Bioelectronics at TU Delft, talks about the past, present and future of her field of research.

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TU Delft "Female Fellowship" Tenure Track Academic Positions

All academic levels; apply before Jan 8, 2018.

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Denk de koffiezet aan

Elon Musk droomt hardop van telepathische communicatie en van een veel grotere geheugeninhoud. Het zijn ideeën die wetenschappers en hippies in de sixties al koesterden, maar die vandaag nog gul op scepticisme stoten. Artikel van Tomas Van Dijk, in de Belgische krant De Standaard, d. 4 augustus 2017. Met bijdragen van Dirk de Ridder (University of Otago, Nieuw-Zeeland) en Wouter Serdijn (TU Delft / Bioelectronics).

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Hebben wij het eeuwige leven?

Artikel in De Telegraaf, d. 29 juli 2017, van Wouter van Bergen, over transhumanisme en de rol van technologie. Met daarin een interview met Wouter Serdijn (TU Delft/Bioelectronics).

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Samprajani Rout's ISCAS 2017 paper among top papers of the conference

ISCAS 2017 paper No. 1849, entitled “Structured Electronic Design of High-Pass ΣΔ Converters and Their Application to Cardiac Signal Acquisition” has been selected as one of the top contributions to the conference and an extended version of the paper has been invited for the TBioCAS Special Issue on ISCAS 2017. Authors of the paper are Samprajani Rout and Wouter Serdijn (Section Bioelectronics)

Abstract of the paper:

Achieving an accurate sub-Hz high-pass (HP) cutoff frequency and simultaneously a high accuracy of the transfer function is a challenge in the implementation of analog-to-digital converters for biomedical ExG signals. A structured electronic design approach based on state-space forms is proposed to develop HP modulators targeting high accuracy of the HP cutoff frequency and good linearity. Intermediate transfer functions are mathematically evaluated to compare the proposed HP Sigma-Delta topologies with respect to dynamic range. Finally, to illustrate the design method, an orthonormal HP Sigma-Delta modulator is designed to be implemented in 0.18 um technology which achieves a linearity of 12 bits.

NWO Take-Off Grant (Phase 1) for Ide Swager and Menno Gravemaker (Momo Medical) and Wouter Serdijn (Section Bioelectronics)

Pressure ulcer wounds are a global problem in healthcare institutions, still. These wounds cause a lot of pain and discomfort for the patient, a high workload for the caregivers and cost a lot of money, in the EU alone already more than 15 billion Euros each year. TU Delft spin-off Momo Medical has developed a smart sensor bed sensor that solves this problem.

In this project, the following steps are taken to test the smart bed sensor in practice, in the Living Lab of the Reinier de Graaf Hospital. In addition, further commercial development is done by approaching more potential customers and understanding the cost structure of the product better when scaling up.

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Vasiliki Giagka elected member of the IEEE Biomedical and Life Science Circuits and SystemsTechnical Committee

At its annual meeting during the International Symposium on Circuits and Systems, Vasiliki Giagka (Section Bioelectronics) was elected member of the IEEE Biomedical and Lifescience Circuits and Systems Technical Committee.

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ABN Amro gaat betalen met je ring mogelijk maken

ABN Amro claimt de eerste bank ter wereld te zijn die het mogelijk maakt om met een ring te betalen in plaats van met een pinpas. De bank experimenteert daar momenteel mee met een selecte groep van klanten. Hoeveel mensen met de ring willen betalen, is nog maar de vraag. Volgens hoogleraar bio-elektronica Wouter Serdijn hangt dat ook af van wat de ring nog meer voor functies krijgt. Item van de NOS, ook verschenen bij Finanzen en PowNed, d. 22 juni 2017.

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NWO Demonstrator Grant awarded to Wouter Serdijn (Bioelectronics) and Cees-Jeroen Bes (in-Holland)

We recently developed a radically new technique, coined "additive companding", which solves important technological limitations of current neural recording systems. The technology has been patented, tested in the lab as proof of concept and is now ready to be developed further into a prototype. The foreseen prototype will allow for continuous and complete monitoring of neural activity, offers better performance and consumes drastically less volume (<400 µm x 400 µm x 400 µm) and energy (<<1 mW) than neural monitoring systems that currently exist or are under development. Clinically, the continuous and complete neural monitoring will offer new insights into the exact workings of nerve and brain tissue and it becomes possible to take the first step into the development of active medical implants that adjust themselves to the therapeutical needs of the patient without subjective measures. This, ultimately, enhances the health-related quality of life of patients with nerve and/or brain disorders and allows for a better treatment of a larger variety of nerve and brain disorders.

In de Zweedse trein kun je inchecken met een onderhuidse chip

Alleen uw hand even omhooghouden, waarna de treinconducteur die met zijn smartphone aanraakt en 'bliep': u bent ingecheckt. In Nederland is dit nog toekomstmuziek, maar in Zweden beleven treinreizigers momenteel de wereldwijde primeur in het openbaar vervoer: inchecken met een onder de huid aangebrachte microchip. Artikel in De Volkskrant en in De Morgen, d. 17 juni 2017, met een bijdrage van Wouter Serdijn

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This is how we will become bionic super humans

Tech companies want to fix spinal cord injuries and make enhanced super humans that communicate through telepathy, or so Prof. Wouter Serdijn heard at a meeting this spring in Washington. There are some snags though.

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Alberto Gancedo-Reguilon awarded grant from the Delft University Fund and Electrical Engineering Alumni

A year ago our faculty took part in a pilot mailing of the University Fund to acquire funding by alumni. The result was positive with a result of €5000 to fund a student project at EEMCS.

The selected project for this funding is of a Spanish Bachelor student called Alberto Gancedo, who did an internship at our Micro-Electronics department (Section Bioelectronics) and at HealthTech BV. He is working on an aEEG Measurement System. His goal is to create a portable and affordable tool to track brain development of neonatal babies. These tools are already available, in developed countries. However, these are big and expensive devices. Alberto's tool can be used in any hospital, instead of just a few, and also in developing countries because of low production costs and its small size. The prototype is ready and Alberto will return to Delft in September to start his Masters' degree and to continue with this project.

About the University Fund

The University Fund would like to give young talent the chance to shine. Therefore they hand out funding for e.g. internships abroad, study trips and participation at international conferences. Excellent achievements are rewarded too with funding and recognition.

Acting on the potential of action potentials: will bioelectronic medicines be the next biologics?

Article by Emma Dorey in The Pharmaceutical Journal, 9 DEC 2016. In there, an interview with Wouter Serdijn

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Universiteit van Nederland: Hoe kun je een dove laten horen en een blinde laten zien?

Hoe kun je een dove laten horen en een blinde laten zien?

Door prof. dr. ir. Wouter Serdijn

Doven weer laten horen en blinden weer laten zien: het lijkt misschien een godswonder, maar in principe heb je genoeg aan een superslimme chip. Hoe dat precies werkt weet elektronicus Wouter Serdijn (TU Delft) als geen ander. Laat je rondleiden in een wereld die zich op de vierkante millimeter afspeelt en ervaar zelf hoe het klinkt om met een chip te horen.

prof. dr. ir. Wouter Serdijn

Je lijf aansturen met behulp van bio-elektronica, dat is de tak van sport van prof. dr. Wouter Serdijn (TU Delft). Met behulp van implanteerbare chips in je lijf kun je je brein een handje helpen om losse elektronische eindjes weer goed aan elkaar te knopen. Het gevolg? Patiënten beter laten zien, horen of minder laten trillen (bij bijvoorbeeld Parkinsonpatienten).

De Universiteit van Nederland

Uitgezonden op 14 november 2016, om 20:30 uur. De Universiteit van Nederland is te bekijken via YouTube,,, Ziggo TV en sinds kort aan boord van alle KLM-vliegtuigen. De stichting wordt gesteund door 13 Nederlandse universiteiten, Ziggo, Deloitte, DELA en Shell.

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Vacancy: Team manager for Electrical Engineering Education (EEE)

The Faculty of EEMCS is creating a special team to fully focus on teaching using our unique and innovative ‘Delft method’. This method integrates practical and theoretical electrical engineering education and trains students to be hands-on, theoretically versed electrical engineers ready for a future career in science or industry.

We are looking for a team manager specialising in Electrical Engineering Education (EEE) who will be both a group leader and a teacher in his/her capacity as the role model of EE Education.

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Vacancy: Assistant/Associate Professor of Bioelectronics

Department/faculty: Electrical Engineering, Mathematics and Computer Science Level: PhD degree Working hours: 38 hours per week Contract: Tenure track with possibilities for advancement Salary: €3400 to €6299 per month gross

Electrical Engineering, Mathematics and Computer Science

The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) is known worldwide for its high academic quality and the social relevance of its research programmes. The faculty's excellent facilities accentuate its international position in teaching and research. Within this interdisciplinary and international setting the faculty employs more than 1100 employees, including about 400 graduate students and about 2100 students. Together they work on a broad range of technical innovations in the fields of sustainable energy, telecommunications, microelectronics, embedded systems, computer and software engineering, interactive multimedia and applied mathematics. EEMCS: Your Connection to the Future.

The Department of Microelectronics has a strong interdisciplinary research and education programme in the areas of 1. health and well-being 2. next generation wireless and sensing technology and 3. safety and security. With 11 IEEE Fellows among the staff, an excellent microfabrication infrastructure, electrical and physical characterisation facilities, and a strong international academic and industrial network, the department provides high-level expertise in each of these areas throughout the entire system chain.

The Bioelectronics section is a relatively new section that has been created to address coherently the challenges we face in developing wearable, injectable and implantable medical devices. This group conducts research, education and valorisation in the fields of ultra low-power analog and mixed-signal circuits and systems for active wearable, implantable and injectable biomedical microsystems.

Job description

The Bioelectronics group is offering a tenure-track position at the Assistant or Associate Professor level in the field of biomedical circuits and systems. You will further develop existing research topics, such as analog and mixed-mode circuits and systems for wearable and implantable medical devices and create new topics, which may include electroceuticals. You will be involved in teaching at the BSc and MSc levels in the TU Delft's Electrical Engineering and Biomedical Engineering programmes. Collaborative initiatives are strongly encouraged. You are expected to write research proposals for national and international funding organisations. This is a tenure-track position for a period of five years with the possibility of a permanent faculty position at the end of the contract, subject to mutual agreement.

A Tenure Track, a process leading up to a permanent appointment with the prospect of becoming an Associate or Full Professor, offers young, talented academics a clear and attractive career path. During the Tenure Track, you will have the opportunity to develop into an internationally acknowledged and recognised academic. We offer a structured career and personal development programme designed to offer individual academics as much support as possible. For more information about the Tenure Track and the personal development programme, please visit


You must have a PhD degree in the field of biomedical circuits and systems (BioCAS) and some years of experience as a post-doc or university professor. You have an excellent academic track record, reflected by peer-reviewed journal publications, conference contributions, and international research experience. An affinity for working on the interface with other disciplines (biomedical engineering, neuroscience, electrophysiology, etc.) and with clinicians and medical researchers is preferred. You should have a demonstrated ability to initiate and direct research projects and to obtain external funding. Experience in teaching and mentoring of students is required. A teaching qualification is recommended. Demonstrated ability in written and spoken English is required.

Conditions of employment

A tenure-track position is offered for six years. Based on performance indicators agreed upon at the start of the appointment, a decision will be made by the fifth year whether to offer you a permanent faculty position. The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children's Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. The TU Delft sets specific standards for the English competency of the teaching staff. The TU Delft offers training to improve English competency. Inspiring, excellent education is our central aim. If you have less than five years of experience and do not yet have your teaching certificate, we allow you up to three years to obtain this.

Information and application

For more information about this position, please contact Prof. Wouter Serdijn, e-mail: To apply, please provide a detailed CV, publication list, and a written statement on your research and teaching interests and vision along with a letter of application and the names and contact details of at least three references. Please e-mail your application by 1 December 2016 to L. M. Ophey, When applying for this position, please refer to vacancy number EWI2016-38.

Enquiries from agencies are not appreciated.

Boek: Vonken in de meterkast (Eng: Sparks in the meter box)

De schokkende strijd tegen depressie, Parkinson en andere hersenziekten

Ons brein is een meterkast, een netwerk van kabels dat het lichaam van stroom voorziet. Soms ontstaat er kortsluiting - kabels slijten, stoppen slaan door - met hersenziekten als gevolg. Op dat moment kan elektriciteit uitkomst bieden. Depressie, Parkinson en chronische pijn; met een stroomstoot kunnen steeds meer mensen van hun klachten worden afgeholpen.

In Vonken in de meterkast laat Bart Lutters ons kennismaken met de fascinerende wereld van de neurostimulatie; van de allereerste vonk tot de nieuwste wetenschappelijke ontwikkelingen. Wie is er ooit op het idee gekomen om een patiënt onder stroom te zetten? Welke ziektes kunnen er met stroom behandeld worden? En wat doet zo'n stroomstoot eigenlijk met onze hersenen? Vonken in de meterkast gaat over elektrische vissen en op-afstand bestuurbare stieren, robotarmen en gereanimeerde ledematen, maar vooral over hoe stroom ons al duizenden jaren beter maakt.

bart_luttersBart Lutters is zijn artsenopleiding aan het afronden (Selective Utrecht Medical Master) en wordt gefascineerd door alles wat met de hersenen te maken heeft. Hij heeft diverse prijzen gewonnen voor zijn onderzoek naar epilepsie en schrijft regelmatig over de geschiedenis van de geneeskunde in onder andere Brain, het toonaangevende wetenschappelijke tijdschrift op het gebied van de neurowetenschappen.

Vonken in de meterkast is vanaf 14 oktober verkrijgbaar in de betere boekhandel, ook online te bestellen via

Wouter Serdijn (hoogleraar bioelektronica aan de TU Delft) heeft middels interviews aan de inhoud van dit boek bijgedragen.

Wouter Serdijn on Dutch radio station Radio 1

In the late evening show "Met het Oog op Morgen" of August 2, Wouter Serdijn comments on the future developments of Bioelectronic Medicine

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New Book: Analog IC Design Techniques for Nanopower Biomedical Signal Processing


As the requirements for low power consumption and very small physical dimensions in portable, wearable and implantable medical devices are calling for integrated circuit design techniques using MOSFETs operating in the subthreshold regime, this book first revisits some well-known circuit techniques that use CMOS devices biased in subthreshold in order to establish nanopower integrated circuit designs. Based on the these findings, this book shows the development of a class-AB current-mode sample-and-hold circuit with an order of magnitude improvement in its figure of merit compared to other state-of-the-art designs. Also, the concepts and design procedures of 1) single-branch filters 2) follower-integrator-based lowpass filters and 3) modular transconductance reduction techniques for very low frequency filters are presented. Finally, to serve the requirement of a very large signal swing in an energy-based action potential detector, a nanopower class-AB current-mode analog multiplier is designed to handle input current amplitudes of more than 10 times the bias current of the multiplier circuit. The invented filter circuits have been fabricated in a standard 0.18 µ CMOS process in order to verify our circuit concepts and design procedures. Their experimental results are reported.



Analog integrated circuit, Biomedical electronics, Bionic ear, Bio-potential, CMOS, Current-mode, Cochlear implant, ECG, Filter, Gm-C, Multiplier, Neural recording, Sample-and-hold, Signal processing, Subthreshold, Switched-current, Transconductance reduction, Transconductor, Weak inversion

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FCA & CNHi Award for Alessandro Urso

Alessandro Urso, PhD student Bioelectronics, received an award from Fiat Chrysler Automobiles (FCA) and CNH Industrial for his MSc thesis that has been awarded Summa Cum Laude. The award ceremony was held on the 31st of May in the headquarters of Fiat inTurin, Italy.

Alessandro, formerly MSc student of the University of Ferrara, Italy, did his MSc thesis project on the design of world's most energy efficient multi-channel neurostimulator IC and was supervised by Gianluca Setti (U. Ferrara) and Wouter Serdijn (TU Delft).

Currently, Alessandro is working towards his PhD degree in the Bioelectronics Section of TU Delft.

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OCW Course Analog Integrated Circuit Design largest number of page views in 2015

Analog Integrated Circuit Design (ET4252) is an introductory course in analog circuit synthesis for microelectronic designers.

Topics include: Review of analog design basics; linear and non-linear analog building blocks: harmonic oscillators, (static and dynamic) translinear circuits, wideband amplifiers, filters; physical layout for robust analog circuits; design of voltage sources ranging from simple voltage dividers to high-performance bandgaps, and current source implementations from a single resistor to high-quality references based on negative-feedback structures.

The course coordinator and teacher of the course is Wouter A. Serdijn.

The course can also be downloaded from iTunes University via:

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How can you get a deaf person to hear and a blind person to see again?

Prof. Wouter Serdijn, head of the bioelectronics Department will give the lecture: 'Hoe kun je een dove weer laten horen en een blinde weer laten zien?' (How can you get a deaf person to hear and a blind person to see again?) for the Universiteit van Nederland. This lecture, lasting around 15 minutes, is part of a lecture series on the senses, in which a total of five leading scientists are taking part. The recordings will take place on Tuesday 31 May. Students and staff at TU Delft receive a 25% discount on the ticket price. The lectures will be in Dutch.

For information about tickets please visit the website from the Universiteit van Nederland

Vasso Giagka in Quadraad

This section features stories by two new members of EEMCS staff. This time they are Vasiliki Giagka and Johan Bosman.

Vasiliki GiagkaVasiliki Giagka
Is assistant professor in the Microelectronics department / Bioelectronics group.

Vasiliki Giagka (1984) was born in Athens. After studying Electronic and Computer Engineering at the Aristotle University of Thessaloniki, she completed her PhD at University College London in 2014. She has been living in Rotterdam since September. It will take her a while to get used to the Netherlands, far away from her friends in London. But she is happy with her bike, which gives her the freedom to go anywhere. Vasiliki Giagka joined the Microelectronics department in September 2015 as one of the three new tenure trackers. This quarter, she is teaching the courses Bioelectricity and Biomedical Engineering. Together with Prof Wouter Serdijn and Dr Reza Lotfi, she is developing a new course on Active Implantable Biomedical Microsystems.
Her research at TU Delft is still in its early stages. She is working on a European project proposal with a large number of partners. It’s an exciting process. In London, she was part of the European Neuwalk project, aimed at repairing the body’s motor functions after serious cases of paraplegia from spinal cord injury. Giagka: As part of Neuwalk, I focused on developing low-power flexible implants to repair the motor system. In her free time, Giagka likes practising yoga and learning new languages. Giagka: Language learning expands the mind. Language also reveals a lot about a country’s culture. For example, in Greece, they do not have a good word for the term deadline. In addition to Greek and English, she has also studied some German, French, Spanish and, now Dutch. Giagka: I am currently midway through level A2.

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Wouter Serdijn receives the 2016 IEEE Circuits and Systems Meritorious Service Award

IEEE CAS award for Wouter Serdijn

Wouter Serdijn (Section Bioelectronics) received from the IEEE Circuits and System Society (CAS) the Meritorious Service Award. This award honors the individual with exceptional long-term service and dedication to the interest of the CAS Society. Wouter Serdijn was awarded for his extraordinary leadership in improving technical quality and organization of IEEE CASS Flagship Conferences, such as the IEEE International Symposium on Circuits and Systems and the IEEE Biomedical Circuits and Systems Conference, and Transactions, in particular the IEEE Transactions on Circuits and Systems.

The award ceremony will be next week in Montreal during the annual ISCAS conference.

New book: Design of Efficient and Safe Neural Stimulators - A Multidisciplinary Approach

About this book:

This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinsons, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples.

About the authors:

Marijn N. van Dongen was born in Pijnacker, The Netherlands, in 1984. He received the M.Sc. and Ph.D. degrees in electrical engineering from the Delft University of Technology, Delft, The Netherlands, in 2010 and 2015, respectively. His research interests include the design of neural stimulator output circuits as well as the modeling of the electrophysiological and electrochemical processes during electrical stimulation. Currently he is working for NXP Semiconductors, Nijmegen, The Netherlands. Dr. van Dongen served as the Financial Chair of the IEEE BioCAS2013 Conference.

Wouter A. Serdijn (M'98, SM'08, F'11) was born in Zoetermeer ('Sweet Lake City'), the Netherlands, in 1966. He received the M.Sc. (cum laude) and Ph.D. degrees from Delft University of Technology, Delft, The Netherlands, in 1989 and 1994, respectively. Currently, he is full professor of bioelectronics at Delft University of Technology, where he heads the Section Bioelectronics. His research interests include low-voltage, ultra-low-power and ultra wideband integrated circuits and systems for biosignal conditioning and detection, neuroprosthetics, transcutaneous wireless communication, power management and energy harvesting as applied in, e.g., hearing instruments, cardiac pacemakers, cochlear implants, neurostimulators, portable, wearable, implantable and injectable medical devices and electroceuticals.
He is co-editor and co-author of 9 books, 8 book chapters and more than 300 scientific publications and presentations. He teaches Circuit Theory, Analog Signal Processing, Micropower Analog IC Design and Bioelectronics. He received the Electrical Engineering Best Teacher Award in 2001, 2004 and 2015. Wouter A. Serdijn is an IEEE Fellow, an IEEE Distuingished Lecturer and a Mentor of the IEEE.

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New project "Earlier recognition of cardiovascular diseases" approved

Atrial fibrillation (AF) is a progressive disease and associated with severe complications such as stroke. Early treatment of AF is of paramount importance as it inhibits disease progression from the treatable (recurrent intermittent) to the untreatable (permanent) stage of AF. However, early treatment is seriously hampered by lack of accurate diagnostic instruments to recognize patients who will develop new onset AF or progress to a severer form of the disease.

The goal of this project is to develop age and gender based, bio-electrical diagnostic tests, the invasive and non-invasive AF Fingerprint, which consists of electrical atrial signal profiles and levels of atrial specific tissue/blood biomarkers. In daily clinical practice, this novel diagnostic instrument can be used for early recognition or progression of AF by determination of stage of the electropathology. As such, AF Fingerprinting enables optimal AF treatment, thereby improving patients outcome.

The project is a collaboration between Erasmus University (Dept. Cardiology), VU Medical Center (Dept. Physiology), and TU Delft (Sections CAS and Bioelectronics), and will fund 4 PhD students.

2016 IEEE Biomedical Circuits and Systems Conference (BioCAS 2016), Oct. 17-19 | Shanghai, China

IEEE BioCAS is a premier international forum for researchers and engineers to present their state-of-the-art multidisciplinary research and development activities at the frontiers of medicine, life sciences, and engineering. The conference will enable members of circuits and systems communities to broaden their knowledge in emerging areas of research at the interface of the life sciences and engineering.

BioCAS 2016 comprises invited talks on cutting-edge development, insightful tutorials in engineering and medicine, demonstrations, and technical sessions. The three-day program of BioCAS 2016 is multidisciplinary in topics including but not limited to:

  • Bio-inspired and Neuromorphic Circuits and Systems
  • Bio-medical Sensors and Interfacing Circuits
  • Biomedical Imaging Technologies & Image Processing
  • Electronics for Brain Science
  • Genomics and Systems Biology
  • Implantable and Wearable Devices and Systems
  • Internet of Things (IoT) for Healthcare
  • Innovative Circuits for Medical Applications
  • Lab-on-Chip/BioMEMS/Point-of care Devices
  • Medical Information Systems and Bioinformatics
  • Rehabilitation and Assistive Technologies
  • Signal Processing Systems for Bio-medical Applications
  • Therapeutic Devices and Closed-loop Systems
  • Wireless and Energy Harvesting/Scavenging Technology

Call for Papers

The complete 4-page paper (in standard IEEE double-column format), including the title, authors' names, aliations and e-mail addresses, as well as a short abstract and an optional demonstration video link (3 minutes max) are requested during submission. Papers must be submitted electronically in PDF format through

Important dates:

  • Special Session Proposal Due: June 5, 2016
  • Paper Submission Due: June 15, 2016
  • Demonstration Proposal Due: July 31, 2016
  • Author Notication Date: August 31, 2016
  • Author Registration Date: September 15, 2016
  • Conference Dates: October 17-19, 2016
  • Post Conference Workshop Dates: October 20-21, 2016


Selected BioCAS2016 papers will be published in the IEEE Transactions on Biomedical Circuits and Systems Special Issue.

BrainCAS, a 2-day post conference workshop, will be held in Hangzhou (a beautiful city near Shanghai) from Oct. 20-21, 2016. More details of BrainCAS will be available in BioCAS2016 website soon.

New book by Amir Zjajo: Brain-Machine Interface

low-power analog front-end circuits for brain signal conditioning and quantization and digital back-end circuits for signal detection

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Happy 2016!

Here are some pictures of the New Year Reception of the Microelectronics department

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Summa Cum Laude for Alessandro Urso

Alessandro received this honorary distiction from the University of Ferrara, Italy. His supervisors were Gianluca Setti and Wouter Serdijn. Alessandro will continue his studies as a PhD student at Delft University of Technology, working on wireless enerfy harvesting for autonomous wireless sensor nodes.

How do you become Best Lecturer of TU Delft?

On 26th November, the Best Lecturer of the year 2015 was chosen. 8 nominees, one from each faculty, competed for the prize. But how do you become lecturer of the year of lecturer or your faculty? How does the lecturer of the year differentiates him or herself from the other lecturers? Is the interaction with the students different and what is the Golden tip?

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TU Delft Female Fellowship Tenure Track Openings

Academic openings at all professor levels

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Optogenetics: lighting the way to the future

The brain is the mystery of the human body. Neurons, as primary units of the nervous system, are joined together into a complicated biological interconnected network. A conventional method to manipulate the neural performance within this network is to use drugs that alter the chemical balance of the brain. However, a crucial aspect of the nervous systems is the electrical signalling between the neurons. Bioelectronics has advanced the neural modulation techniques beyond the conventional methods by developing electrical brain stimulation tools. Electrical brain stimulation is truly beneficial to understand the mechanism underlying neural behaviour, and develop novel therapeutic methods. Optogenetics is another breakthrough method in neural stimulation techniques, which has opened up entirely new avenues of research opportunities in the fields of neuroscience and bioelectronics. In this article, the basic principles of optogenetics and a state-of-the-art bioelectronics application for the treatment of epilepsy are described.

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ISCAS 2015 Keynote Presentation Ronald Dekker online

Ronald Dekker's Keynote: From Chips for the Living to Living Chips

Micro-fabricated devices are finding their way to the frontend of medical equipment, where they are the interface between body, or in general living tissue, and machine. They enable better and cheaper diagnostic equipment, they add eyes and ears to minimally invasive instruments such as laparoscopic instruments and catheters, they allow for un-obtrusive monitoring of body functions, they add functionality to implants, and they enable the development of better and personalized medicines. Despite their great promise it has been proven difficult to bring these devices out of the laboratory phase into production. One of the reasons is the lack of a suitable fabrication infrastructure. Much more than standard CMOS or MEMS devices, these medical devices rely on the processing of novel materials, especially polymers, in combination with advanced molding, micro-fluidics, and assembly technologies. At the same time these devices have to be fabricated under strict quality control conditions in a certified production environment.

In the recently granted ECSEL project InForMed a supply chain for the pilot fabrication of these medical devices is organized, which brings together key European technology partners in an integrated infrastructure linking research to pilot and high volume production. The pilot line is hosted by Philips Innovation Services, and open to third party users.

Speaker Biography:

Ronald Dekker received his MSc in Electrical Engineering from the Technical University of Eindhoven and his PhD from the Technical University of Delft. He joined Philips Research in 1988 where he worked on the development of RF technologies for mobile communication. Since 2000 his focus shifted to the integration of complex electronic sensor functionality on the tip of the smallest minimal invasive instruments such as catheters and guide-wires. In 2007 he was appointed part time professor at the Technical University of Delft with a focus on Organ-on-Chip devices. He published in leading Journals and conferences and holds in excess of 50 patents.

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Wouter Serdijn on BNR Eye Openers

Listen here for the recording.

The broadcast has been repeated on: Friday, July 10, at 19:30 hrs, Saturday, July 11 at 9:00 and 15:30 hrs and Sunday, July 12, at 9:00 and 18:30 hrs; also via the App.

Host of Eyeopeners is Marijke Roskam.

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Wouter Serdijn Teacher of the Year 2014-2015

Rationale behind his award is that Wouter Serdijn is "a good lecturer, is involved with his students and conducts important research himself".

This is actually not the first time that Wouter got elected Teacher of the Year. In 2001 and 2004 he already won the cup. This, however, is the first time that he also has been elected Teacher of the Year for the whole faculty, a new distinction that was established in 2012.

Wouter Serdijn is professor in Biomedical Circuits and Systems and heads the Bioelectronics Section at EEMCS.

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ISCAS 2015 in Lisbon a big success

Franco Maloberti, President Elect of the IEEE Circuits and Systems Society mentioned as highlights of the conference:

- The excellent location and organization: "Let me congratulate the General Chairs, Technical Program Chairs and organizing staff with the perfect flow of things and outstanding service to our community";

- Good participation to sessions and good quality of papers;

- Beneficial socialization during coffee breaks and social events; and

- Very successful side events (Special events, John Choma Commemoration, PhD Gold Young Professional, Women in CAS, Conference Leadership).

Wouter Serdijn No. 12 in Vrij Nederland's Nerd 101

Wouter Serdijn (head of the Bioelectronics Section at Delft University of Technology) ended up No. 2 in the category "wearables". To him, wearables are just an intermediate station in the journey into implantables. A special kind of implantables, called "electroceuticals" will complement traditional pharmaceuticals and will help treating patients that suffer from neurological disorders better. On June 10, an item about him and his work appeared in Vrij Nederland. Together with 10 other nerds he ended no. 12 in VN's Nerd 101, the shortlist of the 101 most interesting technologists, inventors and botchers of the Netherlands.

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Leo de Vreede most entrepreneurial TU Delft scientist

During the annual YES!Delft Network Event on 18 May, the Delft Entrepreneurial Scientist Awards (DESA) were presented for researchers who encourage entrepreneurship. Dr Leo de Vreede of the Department of Microelectronics (EEMCS) was named the most entrepreneurial scientist at TU Delft.

Leo de Vreede is an associate professor at the Electronics Research Laboratory. In 2010, he founded the company Anteverta-mw. Building on the knowledge from his PhD research, the company developed a device that drastically accelerates and improves continuity testing of base stations for mobile telephony. As a result, data transfer is improved and energy consumption reduced. The TU Delft spin-off was taken over earlier this year by the American company Maury Microwave Corporation.

Jury chairman and President of the Executive Board Dirk Jan van den Berg praised De Vreede for his involvement with many spin-off companies and patent requests. The scientists received �valorisation bonuses� of �15,000 and �5,000 respectively.

Presentation on electroceuticals: getting better with electricity

On May 6, 2015, Collegerama of TU Delft made video recordings of the lecture Wouter Serdijn gave on Electroceuticals.

Electroceuticals are the electronic counterparts of pharmaceuticals and are miniature electronic devices that interact with the body in an electrical fashion.

In this talk Wouter Serdijn discusses: - neurostimulation and the need to make neurostimulators smaller, more power efficient and more intelligent; - optogenetic neuromodulation and the need to make this new neuromodulation modality operate in a closed-loop fashion; - neurosensing devices to make neurostimulators intelligent and thereby adjust themselves to the therapeutical needs of the patient; - autonomous wireless sensor nodes that can measure temperature or the electrocardiogram without the need for a battery; - an outlook into the future of electroceuticals with the promise to treat a larger variety of neurological and brain disorders better. Click here to start watching the video and slides:

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Delftse promovendus ontwikkelt volgende generatie neurostimulator

Marijn van Dongen is vandaag aan de TU Delft gepromoveerd op het chipontwerp voor een neurostimulator die klein genoeg is om in de schedel aan te brengen, dicht bij de plek waar gestimuleerd moet worden. Normaal gesproken worden neurostimulatoren uitgevoerd in de vormfactor van een pacemaker; vanwege hun afmetingen worden ze in de borst gemplanteerd en via onderhuidse draden verbonden met de elektroden in het hersenweefsel. Deze leads zijn echter gevoelig voor slijtage.

De batterij is echter een beperkende factor bij het miniaturiseren van deze apparaten. Daarom zocht de promovendus naar alternatieve stimulatiescenarios die minder energie gebruiken. Uit simulaties en in vitro-proeven bleek het gebruik van hoogfrequente series stroompulsjes een veelbelovende aanpak. Dit soort pulsjes kunnen op een energie-efficinte manier worden opgewekt dankzij het principe van een geschakelde voeding; een prototype van de neurostimulator was een factor drie zuiniger dan de huidige stimulatoren. Bovendien kan de pulsgebaseerde aanpak verschillende doelen tegelijkertijd activeren en daarmee de doelmatigheid van de behandeling verhogen.

De onderzoekers denken dat kleinere stimulatoren uiteindelijk breder ingezet kunnen worden. Op het moment wordt neurostimulatie vaak nog gezien als laatste redmiddel bij chronische aandoeningen als Parkinson, depressie, pijn en tinnitus. Er is echter nog een scala aan andere mogelijke toepassingen, zoals zoals epilepsie, verslavingen, migraine en dementie.

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Congratulations to Prof. dr. Sarro with her royal honour

Professor Lina Sarro, professor of micro-electronics at the Faculty of Electrical Engineering, Mathematics and Computer Science, has been made a Knight in the Order of the Netherlands Lion, in The Hague.

She received the award because of her original research that resulted in a large scientific body of work and because of her in-depth involvement with her many students. Her pioneering work in the 1980s in the field of infrared sensors led to international acclaim. Since 1987, she has been in charge of research into micro and nanosystems (MEMS and NEMS) at the Else Kooi Lab, which was known previously as the Dimes Institute for Microsystems and Nanoelectronics.

Professor Sarro has published more than 200 articles in scientific journals and has received awards for her work on several occasions. In 2004, she received the Eurosensors Fellow Award, in 2007 the AISEM Career Award, and in 2012 the IEEE Sensors Council Meritorious Award. She is also a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) and a fellow of the Institute of Electrical and Electronics Engineers. She has been praised on account of both her scientific work and her unfailing commitment to providing teaching of a high standard.

To her students, from both inside and outside the Netherlands, she is a figurehead. This applies perhaps in particular to female students and academics. In 2005, Professor Sarro became the first female to join the TU Delft Council of Professors. She is dedicated to emphasising the role of female scientists, in the conviction that it is a waste to use only half of our scientific assets. Her outstanding scientific reputation ensures that her voice is heard in this, and in other issues.

Medical Delta speeds up development of cochlear implants

Uit De Audiciens, februari 2015: CIs (cochleaire implantaten, Red.) volop in ontwikkeling.

Het is een traditie, de refereeravond van KNO/Centrum voor Audiologie en Hoorimplantaten (CAHIL) in het LUMC op de tweede donderdag van het jaar.

Ook op 8 januari 2015 zit de collegezaal weer vol. Het is dan ook een bijeenkomst waar een aantal disciplines uit de hoorbranche samenkomen. KNO-artsen, audiologen, akoepedisten, audiciens, fabrikanten en anderen luisteren naar voordrachten die inzicht geven in nieuwe ontwikkelingen op audiologisch gebied.

De avond wordt geopend door prof. dr. ir. J.H.M. Frijns, hoofd CAHIL. () In het kader van de Medical Delta (een samenwerkingsverband tussen het Erasmus MC in Rotterdam, de TU Delft en het LUMC in Leiden voor de ontwikkeling van medische technologie) is er een presentatie van Johan de Vos die als arts-onderzoeker KNO onderzoek verricht naar nieuwe technologie voor cochleaire implantaten. Onder begeleiding van Wouter Serdijn en Paddy French hebben drie promovendi van de TU een meetversterker (Cees Jeroen Bes), een elektrode ontwerp (Nishant Lawant) en een stimulatorchip (Wannaya Ngamkham) ontwikkeld. Deze technologie wordt onder leiding van Johan Frijns en Jeroen Briaire in het LUMC geimplanteerd en getest door Johan de Vos. Tevens ontwikkelt het LUMC nieuwe meetmethodes voor het terugmeten van de respons van de gehoorzenuw (Dick Biesheuvel).

Lees meer hier:

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10 years of BioCAS, the Biomedical Circuits and Systems Symposium

Taco Kindt, Cees-Jeroen Bes and Hossein Tajeddin win 2nd prize in Proof-It Award contest

During the Proof-It Awards session of Medical Delta at the Border Sessions, Nov. 12 in The Hague, The Netherlands, the team of FetalStar (Taco Kindt, Cees Jeroen Bes (Section Bioelectronics) and Hossein Tajeddin (HealtTech)) won the 2nd prize. Congratulations! The 2nd prize will allow them to continue working on their revolutionary fetal ECG monitoring concept and bring it closer to a prototype.

Wouter Serdijn at the Border Sessions 2014; the international technology festival

As part of the Crossing Borders Festival in The Hague, Wouter Serdijn will give a talk on the Future of Implantable Technology at the Border Sessions, Nov. 12, 13:00 hrs.

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Vacancy: assistant professor in bioelectronics

In the Section Bioelectronics of Delft University of Technology, there is an opening for a tenure track position in bioelectronics.

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Cees-Jeroen Bes and Wouter Serdijn on Dutch TV station RTL4

On Sept. 25, the RTL4 TV program "Editie NL" made a news item on chipping humans. Cees-Jeroen Bes and Wouter Serdijn offered a glimpse into the future.

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Chapter on RF energy harvesting published

Andre Mansano, Mark Stoopman and Wouter Serdijn contributed a chapter on RF energy harvesting to an Elsevier book, entitled "Wearable Sensors: Fundamentals, Implementation and Applications", which appeared this month.

Both BioCAS 2014 papers have been accepted

The paper by Andre Mansano and Yongjia Li and the paper by Marijn van Dongen et al. have been accepted for BioCAS 2014. Congratulations!

An electronic eye on the children

Article in Vrij Nederland (in Dutch), d. Aug. 2, by Marjolein van Trigt about Child Tracking. In there, Wouter Serdijn explains the possibilities, impossibilities and implications of an implantable RFID child tracker. Lees meer op:

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Efficacy of high frequency switched-mode stimulation in activating Purkinje cells; article published

We pre-published an important paper on a new neurostimulation paradigm on arXiv. The paper can be found here:

Abstract: This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well as the axon membrane, it is first shown that switched-mode stimulation depolarizes the cell membrane in a similar way as classical constant amplitude stimulation. These findings are subsequently verified using in vitro experiments in which the response of a Purkinje cell is measured due to a stimulation signal in the molecular layer of the cerebellum of a mouse. For this purpose a stimulator circuit is developed that is able to produce a monophasic high frequency switched-mode stimulation signal. The results confirm the modeling by showing that switched-mode stimulation is able to induce similar responses in the Purkinje cell as classical stimulation using a constant current source. This conclusion opens up possibilities for novel stimulation designs that can improve the performance of the stimulator circuitry. Care has to be taken to avoid losses in the system due to the higher operating frequency.

Authored by: M.N. van Dongen, F.E. Hoebeek, S.K.E. Koekkoek, C.I. De Zeeuw, W.A. Serdijn

BioCAS 2013 "one of the most successful editions"

9th IEEE BioCAS Advancing Healthcare Technology Conference

By Mohamad Sawan

The 9th IEEE BioCAS Advancing Healthcare Technology Conference was held in the Inntel Hotel, located at the river Meuse in the city centre of Rotterdam, the Netherlands from October 31th to November 2nd, 2013.

Nowadays, BioCAS illustrates a new wave of circuits and systems inspired by biology and healthcare, life sciences, physical sciences and engineering with application to medical problems. This BioCAS brought a strong collaboration between the CAS society and biotechnologies by facilitating interdisciplinary collaborations among scientists, engineers and medical researchers and practitioners to solve complex problems and innovating in rapidly growing area of research. The multidisciplinary approach of BioCAS 2013 enabled the CAS community to benefit from live demonstrations, tutorials, special and regular sessions, all covering a wide range of topics: biofeedback and electrical stimulation, bioinspired circuits and systems, biomedical imaging technologies and image processing, BioMEMs, biomedical instrumentations, biosensors, bioactuators, bio-signal processing, body area networks/body sensor networks, electronics for brain science and brain machine interfaces, implantable electronics, innovative circuits and systems for medical applications, lab-on-chip, medical information systems and wireless and energy harvesting /scavenging technology in medicine.

Figure 1

BioCAS 2013 was one of the most successful editions, three keynotes of world renowned experts were given: 1) Dr. Rudy Lauwereins, Vice President at IMEC, Belgium, explained how the combination of advanced process technology, heterogeneous integration, design methodology and application knowledge enables important breakthroughs in health care, diagnostics, monitoring and therapeutic cure. 2) Dr. Dirk de Ridder, Neurological Foundation professor of Neurosurgery at the University of Otago in New Zealand and Founder of the Brain Research center for Advanced, Innovative and Interdisciplinary Neuromodulation, addressed how engineers, basic and clinical neuroscientists and neurosurgeons should collaborate to develop the next generation of 3rd millennium neuromodulation devices. 3)Dr. John Parker of NICTA, the University of New South Wales and Saluda Medical Pty, all three in Australia, described how closed loop control of amplitude provides significant improvements in spinal cord stimulation to relieve pain.

The first day, the conference included four tutorials: 1) Dr. Shuenn-Yuh Lee presented Low Power Wireless ECG Acquisition and Cardiac Stimulation SOCs for Body Sensor Networks. 2) Drs. Trac D. Tran, Ralph Etienne-Cummings, Yuanming Suo, Jie Zhang, and Sang Chin presented how can compressed sensing help realize very-large scale embedded microelectrode arrays (VLSE-MEA). 3) Drs. Rahul Samant, Vivian Mushahwar, Ralph Etienne-Cummings, and Kevin Mazurek offered a tutorial about smart neural prostheses: design, development, and current state of neural prosthetic devices. 4) Dr. Ruud Vullers presented smart systems for healthcare and wellness.

Figure 2

Authors submitted 163 regular contributions (169 including those presented in special and demo sessions). These contributions are originated from 31 countries; 40% from Europe, 40% from Asia/Pacific and 20% from US and Canada. 93 high-quality papers were accepted and included in the final program, which was organized in 11 lecture and 2 poster sessions. In addition to the regular program, a special session on Implantable electronics for neural recording and stimulation was presented. BioCAS uses to pay particular attention on organizing great quality tutorials and posters, the later provided opportunity for lively discussions and productive exchange of ideas. The entire review process was carried out using ePapers, a professional on-line, web-based review system, involving 277 reviewers who have completed 600 reviews giving on average 3.6 reviews for each paper.

The final program provided ample opportunity for scientific discussions and time for site seeing and social interactions. Breaks, receptions, banquet, lunch times brought the scientific community closer. The standing rooms of the conference were a testament to the incredible quality of this year BioCAS. Detailed program and pictures of the conference, courtesy of the IEEE BioCAS local committee, are available at the IEEE BioCAS website (

The leadership of Dr. Wouter Serdijn, and Dr. Firat Yazicioglu, General co-chairs, as well as Dr. Gianluca Setti, and Tor Sverre (Bassen) Lande, Technical program co-chairs, guaranteed the success of the conference organization. These experienced colleagues were supported by several graduate students and the event was sponsored and supported by the IEEE, the IEEE Circuits and Systems Society (CASS), the IEEE Electronics in Medicine and Biology Society (EMBS), Delft University of Technology, IMEC Belgium, Advanced Bionics, the Biomedical Electronics Foundation and SystematIC.

Figure 3

The banquet of the conference took place on board of a modern and luxurious ship, where attendees enjoyed a unique dining experience and stunning scenery of the many architectural highlight of Rotterdam while the ship cruises around the city and Europe's largest port. In addition to an unforgettable Dinner, the committee delivered one of society best paper awards to one of the Authors who Selected BioCAS to receive his award.

The next BioCAS conference is sponsored by the cole Polytechnique Fdral de Lausanne (EPFL) and will be held on the shores of Lake Geneva, Lausanne, Switzerland on 22 to 24 October 2014.

Both ESSCIRC papers have been accepted

The papers of Yao Liu (on a phase-domain AGC for Bluetooth LE) and Andre Mansano (on an autonomous wireless temperature tag) have both been accepted for presentation at the upcoming European Solid-State Circuits Conference.

Wouter Serdijn representing IEEE in Brussels as a member of the IEEE ICT Working Group

Wouter Serdijn (Section Bioelectronics) has been elected and appointed by the IEEE Board of Directors to serve on the IEEE Working Group on ICT. Main objective of this working group is to increase IEEEs presence and visibility on EU issues relating to ICT and provide the technical know-how to be integrated into EU policy. As IEEE is the world's largest professional association dedicated to advancing technological innovation and excellence for the benefit of humanity, operates transnationally and in a neutral fashion and has the technical competence in this domain, it is only natural that IEEE gives advice on ICT technological matters and acts as a sounding board, Wouter says. In the IEEE Working Group on ICT, 14 members from various EU member states are active.

ISCAS 2014 a big success!

Wouter Serdijn (Section Bioelectronics) served as Technical Program Chair for this year's edition of ISCAS. Next year's edition will be held in Lisbon, Portugal. For this edition Wouter Serdijn will change hats and be General Chair.

Analog Integrated Circuit Design more than 10,000 page views in 2013

Open CourseWare course Analog Integrated Circuit Design (ET4252) received more than 10,000 page views in 2013 and is the No. 2 OCW course in Microelectronics

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Active Implantable Biomedical Microsystems Course

Active Implantable Biomedical Microsystems Course

Vasiliki Giagka, Virgilio Valente, Christos Strydis, Wouter Serdijn
Delft University of Technology and Erasmus Medical Center

Course on the understanding, design and future developments of active implantable biomedical microsystems, such as cochlear implants, cardiac pacemakers, spinal cord implants, neurostimulators and bioelectronic medicine.

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Smart Sensor Systems 2018

Smart Sensor Systems 2018

This course addresses the design and development of smart sensor systems. After a general overview, various key aspects of sensor systems are discussed: measurement and calibration techniques, the design of precision sensor interfaces, analog-to-digital conversion techniques, and sensing principles for the measurement of magnetic fields, temperature, capacitance, acceleration and rotation. The state-of-the-art smart sensor systems covered by the course include smart magnetic-field sensors, smart temperature sensors, physical chemosensors, multi-electrode capacitive sensors, implantable smart sensors, DNA microarrays, smart inertial sensors, smart optical microsystems and CMOS image sensors. A systematic approach towards the design of smart sensor systems is presented. The lectures are augmented by case studies and hands-on demonstrations.

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PhD Thesis Defence

Front-End ASICs for 3-D Ultrasound: From Beamforming to Digitization

Chao Chen

12:00 - 12:15 Introductory presentation
12:30 - 13:30 Public defense
13:45 - 14:00 Diploma ceremony
Address: Senaatszaal of the Aula Congress Center

This thesis describes the analysis, design and evaluation of front-end application-specific integrated circuits (ASICs) for 3-D medical ultrasound imaging, with the focus on the receive electronics. They are specifically designed for next-generation miniature 3-D ultrasound devices, such as transesophageal echocardiography (TEE), intracardiac echocardiography (ICE) and intravascular ultrasound (IVUS) probes. These probes, equipped with 2-D array transducers and thus the capability of volumetric visualization, are crucial for both accurate diagnosis and therapy guidance of cardiovascular diseases. However, their stringent size constraints, as well as the limited power budget, increase the difficulty in integrating in-probe electronics. The mismatch between the increasing number of transducer elements and the limited cable count that can be accommodated, also makes it challenging to acquire data from these probes. Front-end ASICs that are optimized in both system architecture and circuit-level implementation are proposed in this thesis to tackle these problems.
The techniques described in this thesis have been applied in several prototype realizations, including one LNA test chip, one PVDF readout IC, two analog beamforming ASICs and one ASIC with on-chip digitization and datalinks. All prototypes have been evaluated both electrically and acoustically. The LNA test chip achieved a noise-efficiency factor (NEF) that is 2.5 × better than the state-of-the-art. One of the analog beamforming ASIC achieved a 0.27 mW/element power efficiency with a compact layout matched to a 150 µm element pitch. This is the highest power-efficiency and smallest pitch to date, in comparison with state-of-the-art ultrasound front-end ASICs. The ASIC with integrated beamforming ADC consumed only 0.91 mW/element within the same element area. A comparison with previous digitization solutions for 3-D ultrasound shows that this work achieved a 10 × improvement in power-efficiency, as well as a 3.3 × improvement in integration density.

The dissertation can be found in the TU Delft repository:

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Dutch Ultra Low Power Conference

The medicine of the future you’ll need to take only once, and it’s a bioelectronic one

Wouter Serdijn

The Dutch Ultra Low Power Conference brings together Belgian and Dutch professionals and companies involved in the development and application of devices with ultra low power technologies. It targets engineers, designers and technical managers in the advanced field of energy harvesting and ultra low power and energy-efficient designs. The keynote will be given by Wouter Serdijn, professor of bioelectronics at Delft University of Technology.

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MSc CE Thesis Presentation

Energy Efficient Feature Extraction for Single-Lead ECG Classification Based On Spiking Neural Networks

Eralp Kolagasioglu

Cardiovascular diseases are the leading cause of death in the developed world. Preventing these deaths, require long term monitoring and manual inspection of ECG signals, which is a very time consuming process. Consequently, a wearable system that can automatically categorize beats is essential.

Neuromorphic machines have been introduced relatively recently in the science community. The aim of these machines is to emulate the brain. Their low power design makes them an optimal choice for a low power wearable ECG classifier.

As features are crucial in any machine learning system, this thesis aims at proposing an energy efficient feature extraction algorithm for ECG arrhythmia classification using neuromorphic machines. The feature extraction algorithm proposed in this thesis consists of the merger of a low power feature detection and a feature selection algorithm. Also, different network configurations have been investigated to achieve classification using an LSM architecture. The resulting system can accurately cluster seven beat types, has an overall classification rate of 95.5%, and consumes an estimate of 803.62 nW.

MSc ME Thesis Presentation

Fabrication and Characterization of PEDOT coated microelectrode array for Organ on Chip Application

Affan Kaysa Waafi

InScience Festival Movie (Nijmegen)

Cyborgs Among Us

Wouter Serdijn

Imagine having a sixth sense! These are the first cyborgs that transcend the boundaries of human possibility and spark the debate about the technological evolution of mankind. Cyborgs Among Us offers insight into how technology can become part of us and the social and ethical implications associated with it. 

Professor Wouter Serdijn from Delft University of Technology explains technology and the human body from the perspective of bioelectronics.

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MSc BME thesis presentation

SOMNUS: An Ultra-Wideband Radar-Based Approach for Neonatal Sleep State Classification

Maria Silos Viu

br> In the recent years, there has been an increasing awareness of the critical role of sleep for brain development of young infants. During the early neonatal stages of human development, the basic activity of the brain is to sleep. Prolonged sleep is required in infants for further development of the nervous system. Sleep also plays an important role as body temperature regulation and energy saving system. Neonatal sleep is divided into two main different sleep stages: Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM). As the infant develops, sleep stages vary in maturity, length and distribution, thus the importance of the quantification of these stages that could eventually lead to new biomarkers of neonatal brain development.

Nowadays, the gold standard in sleep monitoring are Polysomnography (PSG) studies, in which vital signs, as well as EEG and muscle activity, are recorded during a whole-night study and subsequently, sleep stages are classified by an expert. However, the high obtrusiveness of the multiple electrodes involved in the PSG and its high associated cost make it impossible to be used as routinely monitor system. SOMNUS project was divided into two main goals: (1) accurately measure respiration signals from patients using an ultra-wideband radar module, and (2) detect differences in respiration between REM and NREM phases in order to unobtrusively and automatically score sleep states of infants without the need for an electrode attached to the patient. The system was developed using a training dataset of 22 patients ranging from 3 months to 14 years old age. Previous studies had used radar technology for vital signs detection during the last years. This work provides a new data analysis algorithm to suppress motion artifacts movements from radar signals and increase the robustness of respiration monitoring. Furthermore, it represents the first time such technology is used to monitor sleep in young patients, reaching an overall sleep classification accuracy of 80%.

The BELCA music festival!

Annual Music Festival of the Sections Bioelectronics and Electronics

The BELCA Band, Doe Normaal, Rotterdam Centraal

Annual music festival with two invited bands and of course the BELCA band. Highly recommended. Free entrance.

MSc BME thesis presentation

System Building Blocks for Mathematical Operators Using Stochastic Resonance -- Application in an Action Potential Detection System

Insani Abdi Bangsa

MSc thesis presentation on Stochastic Resonance Systems for Biomedical Applications

The monthly meeting of the Section Bioelectronics

Insani Abdi Bangsa, Kostas Konsolakis

Bioelectronics Colloquium

On the Relationship between Nyquist Rate and Healthcare: Silicon Systems to Close the Sub-Sampling Gap in Health Screening and Monitoring

Amin Arbabian, PhD (Stanford University)

Advances in healthcare technologies have mainly focused on therapeutics, interventional procedures, and “late-stage” diagnostics. These steps have undergone significant improvements, leading to higher survival rates and enhancements in quality of life. Nevertheless, current trends are unsustainable due to the inadequate outcomes on specific critical diseases and skyrocketing national healthcare costs. An important example is cancer, where mortality rates have not seen major improvements, even with the tremendous technological advances in diagnostic imaging tools over the last four decades.

In this talk I will outline our efforts in better marrying technology and healthcare with new systems that 1) enable continuous “Nyquist” imaging and screening to enable preventive/predictive care, and 2) introduce smart implants for precision monitoring and closed-loop therapies. Preventive screening through continuous monitoring has the potential to fundamentally revamp our understanding of disease as well as targeted therapy. Today, the human body is monitored infrequently, perhaps on an annual basis and with a low “resolution”. This is in contrast with advanced electronic systems (many of which our community designs and ships), which are frequently monitored and calibrated. I will summarize a few example projects that aim to address these issues, including portable, semiconductor-based, “Tricorder” imaging systems, ultrasound-powered implantable devices that can measure, detect, and act upon local physiological changes through closed-loop neuromodulation or “electroceuticals”, and finally our new investigation of a noninvasive methods of neuromodulation based on ultrasonic excitation.

Amin Arbabian received his Ph.D. degree in EECS from UC Berkeley in 2011 and in 2012 joined Stanford University, as an Assistant Professor of Electrical Engineering. His research interests are in mm-wave and high-frequency circuits and systems, imaging technologies, and ultra-low power sensors and implantable devices. Prof. Arbabian currently serves on the steering committee of RFIC, the technical program committees of RFIC and ESSCIRC, and as associate editor of the IEEE Solid-State Circuits Letters (SSC-L) and the IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology (J-ERM). He is the recipient or co-recipient of the 2016 Stanford University Tau Beta Pi Award for Excellence in Undergraduate Teaching, 2015 NSF CAREER award, 2014 DARPA Young Faculty Award (YFA) including the Director’s Fellowship in 2016, 2013 Hellman faculty scholarship, and best paper awards from several conferences including ISSCC (2010), VLSI Circuits (2014), RFIC symposium (2008 and 2011), ICUWB (2013), PIERS (2015), and the MTT-S BioWireless symposium (2016).

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Getting Better with Electroceuticals – electronic medicine to the rescue

Wouter Serdijn

Wouter Serdijn will give a keynote at the 23th European Conference on Circuit Theory and Design, Sept. 4-6, 2017, in Catania, Italy

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MSc ME Thesis Presentation

High Density Flexible Interconnect for Minimally Invasive Medical Instruments

Michel van der Kaay

Microelectronics IoT Pitch

and Summer Drink

All ME-MSc’s and ME-employees are cordially invited to make a 2-minute pitch for an interesting and unexpected IoT application.

The format is free like the level of seriousness and feasibility are but there is a meaningful purpose as the event is meant to inspire the definition of technology integrating projects in the field of IoT. The pitches will be ‘graded’ by measuring the intensity of the applause. The pitch wil be followed by the yearly Summer Drink of the Microelectronics Department.

PhD thesis defence Yao Liu

Analysis and Design of Low-Power Receivers: Exploiting Non-50-Ohm Antenna Impedance and Phase-Only Quantization

Yao Liu


Reducing the power consumption of low-power short-range receivers is of critical importance for biomedical and Internet-of-Things applications. Two interesting degrees of freedom (or properties) that have not been fully exploited in the pursuit of low power consumption are the antenna impedance and the phase-only modulation property of FSK/PSK signals. This dissertation explores the possibility of reducing the power consumption of the receiver by utilizing these two degrees of freedom.

The feasibility of using a non-50-ohm antenna impedance in an active receiver front-end is first studied. A general antenna-electronics interface analysis is carried out, suggesting that power transfer is not the only design objective in the interface, but that the impedances of antenna and load need to be optimized for either voltage or current, depending on which is more favorable to measure with the electronics. This principle has been applied to a co-design example of an inductive antenna impedance and a low-noise amplifier (LNA). A passive RF gain can be achieved by using the proposed principle, and hence the noise figure (NF) can be reduced without sacrificing power consumption. The concept of a non-50-ohm antenna impedance is also exploited in the context of passive front-ends (PFEs). An inductive antenna impedance proves beneficial for increasing the passive voltage gain of an antenna-LNA interface. The study of the PFE aims for the same voltage-boosting effect by incorporating the inductive antenna impedance in the PFE. An analysis reveals that the inductive antenna impedance introduces two extra degrees of freedom to increase the downconverted voltage of the front-end for a given antenna available power. In order to well maintain the passive gain offered by the inductive antenna impedance together with its resonant load, the passive mixer should present a high-quality-factor capacitive input. This is achieved by incorporating an intermediate inductance in the passive network. The proposed front-end and a baseband LNA have been implemented to verify the voltage-boosting effect. The implementation has a passive gain of 11.6 dB, which is close to the state-of-the-art of 12 dB.

A promising concept which can fully utilize the phase-only modulation property of FSK/PSK signals is that of phase-domain analog-to-digital converters (PhADCs). This dissertation also deals with the analysis and design of PhADCs. First of all, analytical methods are proposed to comprehensively compare the PhADC and an (in-phase and quadrature) IQ ADC. Phase signal-to-noise ratio (SNR) expressions of the two ADC types are formulated analytically to facilitate a quantitative comparison of the ADCs. In comparison with the IQ ADC, the PhADC, due to its embedded demodulation attribute, is a more compact quantization and demodulation solution when interference accommodation is not required. Moreover, considering a flash ADC as an example of the low resolution (3-4 bit) IQ ADC, the PhADC has a lower theoretical energy limit than the flash IQ ADC for a given phase effective number of bits (ENOB) due to the immunity to magnitude variations and the phase-only quantization, thereby showing the great room for energy efficiency improvement that the PhADC has. Second, having discussed the interesting attributes of the PhADC, an IQ-assisted conversion algorithm and a corresponding circuit topology to improve the energy efficiency of the PhADC are proposed. Thanks to the successive approximation (SAR)-like algorithm and charge-domain operation, the prototype achieves a FoM of 1.2 pJ/step, which is better than the state-of-the-art of 8.3 pJ/step. Finally, the explicit relationship between the input amplitude SNR and the output phase SNR of the PhADC has been formulated. This relationship facilitates the system analysis of a receiver using a PhADC.

Using the proposed PFE and charge-redistribution PhADC, a receiver system is constructed. Based on the measured specifications of the PFE and the PhADC, the simulated performance of a PGA and a 2nd-order filter and the analysis outcomes of the PhADC presented in Chapter 4, the benefit of using the PhADC for a receiver system is quantified. For the proposed PFE and the IEEE 802.15.6 application, two ADCs (for I and Q paths) with a SNR of 30.4 dB are needed if an amplitude ADC is used, while a PhADC with a phase SNR of 24.5 dB (when the input amplitude is -11.9 dBm) is sufficient if a PhADC is used. For an antenna input level of -83.6 dBm (which corresponds to the minimum input level that has been specified for the PhADC), the presented receiver system demonstrates a sufficient overall SNR for the IEEE 802.15.6 standard, thereby paving the way to fully-integrated low-power receivers for the standard.

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MSc thesis presentation

A Low-Complexity CMOS Receiver for UWB siqnals

Ernesto Huaman

Ernesto's MSc thesis presentation on localization using UWB and its implementation in CMOS

NeuroControl Symposium 2017

Electroceuticals -- bio-electronic medicine as an alternative to drugs

Wouter Serdijn

Wouter Serdijn will give a keynote at the 2017 symposium of IMDI NeuroControl on the future of medicine, which will be electronic

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Professoren in de Arena

Professoren in de Arena: De bionische mens, van protheses naar upgrades

Wouter Serdijn, Just Herder, Harrie Weinans, Project March

Op 28 maart gaan drie hoogleraren, waaronder Wouter Serdijn, met elkaar in debat over 'de bionische mens'. Wat is er mogelijk en hoe ver kun, wil en mag je gaan? In drie korte minicolleges praten de heren u bij en worden ze vervolgens stevig aan de tand gevoeld door cabaretier, columnist en TU-docent Jasper van Kuijk. In de discussie die daarop volgt, wordt het publiek van harte uitgenodigd mee te doen.

De sprekers van deze avond zijn:

Just Herder - Professor of Interactive Mechanisms and Mechatronics

Harrie Weinans - Professor of Tissue Biomechanics and Implants

Wouter Serdijn - Professor in Bio-Electronics

Project March

Deze editie van ‘Professoren in de Theaterarena’ wordt georganiseerd i.s.m. het ‘Explore your Brain’ evenement van de TU Delft Library in het kader van het 175 jarig bestaan van de TU Delft.

Over Professoren in de Arena

In nauwe samenwerking met de TU Delft en de universiteiten van Leiden en Rotterdam zetten wij in een theatrale setting steeds drie spraakmakende hoogleraren op het podium rondom een actueel thema. Deze onderwerpen worden van verschillende kanten belicht, vanuit de harde wetenschap en/of maatschappelijke en ethische hoek. In een magazine-achtig format met korte colleges, stand-up colums wordt u bijgepraat en doet u mee in de discussie.

Locatie: Theatercafé, Theater de Veste

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Microelectronics Colloquium

Microelectronics Department Colloquium

Daniele Cavallo, Vasiliki Giagka, Fabio Sebastiano, Rob Remis

On Wednesday March 15 the next Microelectronics colloquium wil take place, including four lectures by staff members.

Please register online by completing the form.

  • Vasso Giagka
    Flexible bioelectronic medicines

    Abstract: Bioelectronic medicines are the next generation of neuromodulation devices: small active three-dimensional neural interfaces able to modulate nerve activity by targeting a specific neural region. They aim to treat a number of conditions, such as diabetes and asthma, in a tailored (per individual) and reversible fashion, avoiding the side effects of conventional drug-based interventions (pharmaceuticals). They achieve so by recording signals from the respective nerves, extracting information and using it as feedback to electrically stimulate the neural region in a closed-loop manner.

    Current technologies for active implants have not yet managed to achieve the miniaturisation and integration levels required for the development of bioelectronic medicines. For such breakthrough devices, novel concepts need to be explored, developed, and tested.

    In this talk I will present my current activities as well as my vision on realizing the first flexible three-dimensional graphene active implant, for safe chronic neural stimulation and recording from the peripheral nerves.

  • Fabio Sebastiano
    Cryo-CMOS for Quantum Computing: does it work?

    Quantum computing holds the promise to change our lives by efficiently solving computing problems that are intractable today, such as simulation of quantum systems for synthesis of materials and drugs. A quantum computer comprises both a quantum processor and a classical electronic controller to operate and read out the quantum devices. The quantum processor must be cooled at cryogenic temperature in order to show quantum behavior, thus making it unfeasible to wire thousands of signals from the cryogenic quantum devices to a room-temperature controller.

    While this issue can be solved by placing also the electronic controller at cryogen¬ic temperature, which electronic technology is the best choice for its implementation? This talk will address the challenges of building such electronic controller, and answer whether a standard CMOS technology can be employed for the required analog and digital circuits operating at 4 K and below.

  • Daniele Cavallo
    Advanced Antenna Arrays for Modern Radar and Communication Systems

    Abstract: Several of today’s radar and wireless communication applications are shifting their operation to higher frequency to fulfil more demanding requirements on resolution, compactness and data rates. For this reason, there is a growing need to develop low-cost integrated circuit transceivers working at millimeter and sub-millimeter waves.

    However, on-chip antennas are currently characterized by very poor radiation efficiency and extremely narrow bandwidth. My approach of combining the concepts of connected arrays with artificial dielectrics will solve the inefficiency problem and enable high-efficiency on-chip antenna designs.

    Similar concepts can be also realized at microwave frequencies in printed circuit board, allowing for low-cost phased array antennas with state-of-the-art performance in terms of scan range, bandwidth and polarization purity.

  • Rob Remis
    Imaging with Waves

    We present an overview of our current wave field imaging and inversion research. Effective inversion strategies for important applications in Magnetic Resonance Imaging (MRI), nano-optics, and subsurface monitoring will be discussed. In particular, dielectric shimming (shaping of the radio frequency field in MRI) as well as inversion algorithms that determine the dielectric properties of various tissue types based on measured MRI data will be considered, and state-of-the-art model-order reduction techniques for large-scale wave propagation problems will be discussed as well.

Monthly meeting of the Bioelectronics Section

Bioelectronics Group meeting

Farnaz Nassirinia, Ronaldo Martins da Ponte, Dieuwert Mul

e talks / discussion items in bioelectronics

MS3 seminar

Capabilities and Research Activities at the University of Oklahoma Advanced Radar Research Center

Prof. Nathan A. Goodman
The Advanced Radar Research Center (ARRC) at the University of Oklahoma

The Advanced Radar Research Center (ARRC) at the University of Oklahoma consists of a vibrant group of faculty and students from both engineering and meteorology, focused on solving challenging radar problems and preparing the next generation of students. Through the collaborative nature instilled in its members, the ARRC has proven effective at developing synergy between science and engineering in the field of radar. The ARRC resides in state-of-art Radar Innovations Laboratory, a one-of-a-kind and unrivalled facility for radar research, development, and education. This 35,000-sqft facility includes microwave labs, advanced fabrication capability, and two anechoic chambers.

Bio Prof. Goodman: Nathan A. Goodman received the B.S., M.S., and Ph.D. degrees in electrical engineering from the University of Kansas, Lawrence, in 1995, 1997, and 2002, respectively. From 1996 to 1998, he was an RF systems engineer for Texas Instruments, Dallas, TX., and from 2002 to 2011, he was a faculty member in the ECE Department of the University of Arizona, Tucson. He is now a Professor in the School of Electrical and Computer Engineering and Director of Research for the Advanced Radar Research Center at the University of Oklahoma, Norman.

Bioelectronics meeting

The monthly meeting of the Section Bioelectronics

Alberto, Gustavo

MS3 seminar

MS3 Master Event

Come to learn about our group and current Master Thesis Projects...

Additional information ...


Wouter Serdijn

De meeste scholieren die hun vwo aan het afronden zijn en erover denken om hun opleiding aan een technische universiteit te vervolgen, verwachten dat uitvindingen die zij daar zullen doen een positieve invloed zullen hebben op belangrijke maatschappelijke zaken. Denk aan duurzame energie, schoon water voor iedereen, een veiliger samenleving, kwaliteit van leven, het doorgronden van het brein,en het vervaardigen van betere medicijnen. En hun verwachtingen zijn terecht. Ingenieurs dragen in belangrijke mate bij aan het oplossen van deze vraagstukken die ons allemaal aangaan.

In deze presentatie laat ik diverse aspecten van de wiskunde en natuurkunde zien die nodig zijn om tot een verbetering van bio-elektronische medicijnen te komen, waarmee ik de relevantie en noodzaak van deze wetenschappelijke talen aantoon. Op een voor een groot publiek behapbare manier komen de volgende onderwerpen aan bod: modellering, chips-technologie, halfgeleiderfysica, exponentiele functie, simplificatie, integraalrekenen, differentiaalvergelijking, fasoren, complexe getallen, schematuur, prototypering, co-design, metingen en interpretatie. De presentatie geeft niet alleen inzicht in het wiskundig en natuurkundig gereedschap, maar ook in de toekomstige ontwikkeling van zogenaamde ‘elektroceutica’, die een grote impact zullen hebben op de toekomstige behandeling van neuronale aandoeningen zoals epilepsie, oorsuizen, verslavingen, migraine en chronische pijn.

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Microelectronics Introduction Colloquium

Introduction 3 new Tenure Trackers

Masoud Babaie, Morteza Alavi, Faruk Uysal

On December 12 we organize the next Microelectronics Colloquium to introduce three new Assistant Professors (Tenure Trackers) of the Microelectronics department. They are happy to present a lecture about their research.

The colloquium start at 15.00 hrs. there will be a drink afterwards in the foyer.
Location: Theatre of Culture Builing (38) Mekelweg 10.
Please register online if you want to attend, latest December 5.

  • Masoud Babaie: Pushing The Limits of CMOS Circuits for Emerging Technologies
    Within the next few years, quantum processors, Fifth Generation (5G) cellular systems and the wireless Internet-of-Things (IoT) are expected to see significant deployment to realize more integration between the physical and digital worlds, promising enormous computation power, high data rate communications and enabling more objects to be remotely sensed and controlled.

    This talk will address some of the main challenges in the design and implementation of IoT devices, mm-wave 5G transceivers, and cryogenic CMOS controller for quantum computers. An overview of my past and ongoing research activities will be also presented, with emphasis on novel solutions to improve power efficiency and spectral purity of RF/mm-wave transceivers.

  • Morteza Alavi: Universal Transmitters for 5G
    Today, our daily activities are intertwined with the Internet. The ever-growing demand to swiftly get access to the data-cloud systems leads to huge data traffic. In order to seamlessly transmit and receive these gigantic data, _ 40 GB, agile radio-frequency (RF) transceivers are inevitable.

    These radios must be capable of supporting the current and future communication standards such as 5th generation of wireless mobile communications. The ultimate goal is that they can be implemented as universal radios whose modes of operation can be defined by their clients. To address these demands, RF transmitters are currently reinvented and are directed towards digital-intensive architecture. In this short presentation, we will briefly describe the strengths,possibilities, and challenges that exist for these advanced transmitters. First and foremost, the concept of RF-DAC based transmitters will be introduced. Next, the talk will review various RF-DAC based transmitters that have already been implemented at ELCA. Eventually, the presentation will concisely unveil the future directions of the research of these software-defined transmitters at ELCA.

  • Faruk Uysal: Distributed Radar Networks: Beyond a single radar
    The number of operational radar is rapidly increasing due to the growing demand of the remote sensing. Software defined radio and emerging single-chip radar technology make use of radars in every aspect of life such as autonomous driving, safety and security applications. With the increase of active transmitters, spectrum management and coexistence started to become a concern for some radar systems. In this talk, the previous applications of waveform, frequency agility will be reviewed to bring multi-functionality to the modern radar system. Finally, we will discuss the future research for distributed radar networks and how to fuse data from various radars to acquire different aspects of a target to be viewed simultaneously.

MSc BME Thesis Presentation

Wireless Power Transfer and Optogenetic Stimulation of Freely Moving Rodents

Farnaz Nassiri Nia

Animal studies are commonly used to test the feasibility and effectiveness of promising novel neuroscience research ideas. One such new technique is optogenetic stimulation, which refers to stimulation of the brain by means of light. Current optogenetic stimulation methods use tethered setups and, typically, the animal-under-study is put into a fixed position. This introduces stress, an obvious reduction in animal welfare, and may thus influence the experimental results. Hence, an untethered setup is highly desirable. Therefore, in this thesis, we propose a complete wireless optogenetic stimulation setup, which allows for full freedom of movement for multiple rodents-under-study in a 40x40x20 cm environment.

This thesis includes a thorough design space exploration and the subsequent development of: an inductive wireless link, a wireless receiver module that resides on the animal, and novel micro-LED array implants.

PhD Thesis Defence Andre Mansano

Radio Frequency Energy Harvesting and Low Power Data Transmission for Asynchronous Wireless Sensor Nodes

Andre Luis Mansano


Since the Internet of Things (IoT) is expected to be the new technology to drive the semiconductor industry, significant research efforts have been made to develop new circuit and system techniques for autonomous/very low-power operation of wireless sensor nodes. Very low-power consumption of sensors is key to increase battery lifetime or allow for battery-less (autonomous) operation of sensors, which contributes to reducing or preventing the high maintenance costs of battery supplied sensors and reduce the amount of discarded batteries.

This thesis, entitled Radio Frequency Energy Harvesting and Low Power Data Transmission for Autonomous Wireless Sensor Nodes, presents very low-power consumption circuit and system techniques combined with energy harvesting that allow the creation of autonomous wireless sensor nodes. This work focuses on three main challenges:
1) how to improve energy harvesting efficiency,
2) how to minimize power consumption of data transmission and
3) howto combine low-power techniques and energy harvesting in a system.
These challenges are addressed in this thesis with on-PCB and integrated circuit (IC) solutions.

The efficiency of radio frequency (RF) energy harvesting is improved by proposing a new topology of a charge-pump rectifier. The proposed topology uses a voltage boosting network to compensate for the voltage drop in the transistors. The new topology is presented as well as a non-linear circuit analytical analysis. Simulation results are compared to the analytical analysis and measurement results of the circuit that has been fabricated in a 0.18 um CMOS technology and operates at 13.53 MHz. Although the efficiency of RF energy harvesting is improved using the above technique, at the same time, low power techniques in data transmission should be developed to save energy. Pulse width modulation and impulse transmission techniques to minimize power consumption have been developed and are presented in this thesis.

The developed pulse modulation circuitry has been fabricated in 0.18 um CMOS technology as part of a System on Chip (SoC). The new impulse transmitter topology for low-voltage low-power operation has been fabricated on PCB with micro-wave discrete components. Theoretical analysis, simulations and measurements results are shown to prove the impulse transmitter concept.

The circuits developed are integrated in a SoC with energy harvesting to prove the concept of autonomous wireless sensor nodes. Two sensor nodes have been designed and measured: one for autonomous temperature monitoring and the second for autonomous ECG monitoring. Both designs operate from wireless power without the use of batteries.

Finally, the work developed in this thesis is analyzed and future research possibilities are discussed.

Additional information ...

MSc ME Thesis Presentation

A 0.6V Low Noise Current Generator for Bio-Impedance Measurements in 40nm CMOS

Yao Li

MSc ME Thesis Presentation

Structured electronic design of high-pass ΣΔ converters and its application to cardiac signal acquisition

Samprajani Rout


With the bandwidth of the ECG signal extending from sub-Hz to 200 Hz, a major challenge in developing the analog front-end responsible for digitizing the analog signal for an ECG readout system lies in implementing the large time-constants on chip due to area constraints. While techniques to obtain very large time constants exist, they are heavily limited by both linearity and accuracy, which clearly dictates the need for alternative structures.

In this thesis, a ΣΔ converter is used for its noise-shaping property to digitize the acquired signal. A structured electronic design methodology based on state-space forms is proposed to develop high-pass (HP) ΣΔ converter topologies. As opposed to conventional low-pass or band-pass ΣΔ, a generalized signal transfer function which includes the high-pass characteristic is used. The proposed HP ΣΔ topologies satisfy the signal transfer function, which is high-pass characteristic in this application and the noise transfer function, which is a 2-nd order noise shaping in this case. Furthermore, the noise contribution of each of the integrators is evaluated and the topologies are compared in terms of their total noise contribution. Finally, one of the structures is implemented in 0.18 um technology as a final step of verification.

Additional information ...

MSc BME Thesis Presentation

aEEG analog front-end IC for neonatal brain development monitoring

Maciej Kostalkowski


Every year number of prematurely born infants grows. Most underdeveloped organ after birth is brain. Therefore its monitoring is very important, especially as it can provide indications about health state in a future, both short and long term. Non invasive method of brain monitoring is aEEG recording.

Although aEEG is already well known and accepted in neonatology, it is still not used to monitor every patient. Problem is high price of a device starting from 30000 euro. In a result, hospital is not able to provide proper monitoring for each and every patient. For this reason, main task of this thesis is to propose cheaper version of a system.

In order to propose cheap design, minimal requirements have to be specified. Two tests were performed. First one was to identify interferences disturbing aEEG recording. Only registered interference was 50Hz spike coming from the mains. Noise floor peak to peak amplitude was measured on 1μV level, while magnitude of 50Hz spike was on the level of 9μV for devices turned off and 25μV for devices turned on.
Second performed test was resolution test. Test showed that in order to keep the number of bits low, amplification of the signal is required. Amplification by factor of 1000 allowed to reduced this value to 7bits.

Proposed system consists of amplifying stage realising 60dB gain with high pass cut off filtration and ADC. Amplifying stage is realised by amplifier providing 35dB gain with filtration below 2Hz and second amplifier realising 25dB gain. ADC is implemented by continuous time second order Sigma Delta Modulator. Proposed system was designed in CMOS 0.18μ and h18a6am technology. Tests of full system showed SNR no lower than 51dB, power consumption of 217.5μV. Input stage has CMRR of 113dB and input impedance above 2.25GΩ for the bandwidth 2-15Hz. System reliability was checked with corner analysis and wide range of temperatures. Results showed small variations of SNR.

MSc ME Thesis Presentation

A 0.6V, 1uW, 0.95µVrms low-power low-noise instrumentation amplifier for ECG/BioZ in 40nm CMOS

Qiuyang Lin


This thesis presents a low-power low-noise instrumentation amplifier designed to be implemented in 40 nm CMOS technology and operating from a 0.6 V supply, intended for use in electrocardiogram (ECG) and bio-impedance (BioZ) signal acquisition. This instrumentation amplifier has one ECG channel, one BioZ channel and allows both signals to be measured at the same time.

The core of the system is an AC-coupled instrumentation amplifier. A DC servo-loop is applied to handle large differential electrode offset (>300 mV) and a positive feedback loop is used to boost the input impedance (>100 MOhms). This instrumentation amplifier achieves low noise (<1 uVrms over a bandwidth of 150 Hz), large CMRR (>100 dB) while only consuming 1 uW of power. The instrumentation amplifier has a noise efficiency factor (NEF) of 2.4 and it occupies only 0.1 mm^2 chip area.

Additional information ...

MSc ME Thesis Presentation

t.b.d. (multi-channel backscattering for reading out the ECoG of freely moving rodents)

Ide Swager

Additional information ...

PhD thesis defence Mark Stoopman

Circuit Design for Highly Sensitive RF-Powered Wireless Sensor Nodes

Mark Stoopman

Emerging applications such as Internet of Things (IoT), smart buildings and warehouse inventory management are important driving forces behind the development of Wireless Sensor Nodes (WSNs). With future advancements made in the semiconductor industry, these WSNs are expected to become smaller, cheaper, more reliable and with improved functionality. The prospect of energy scavenged WSNs is to eliminate the burden of battery replacement, thereby significantly saving on maintenance costs in large WSN networks.

This dissertation focuses on the research, design and implementation of various circuit blocks and the system integration of energy scavenged WSNs used in the aforementioned applications. To select a suitable energy harvester, four different energy harvesting approaches are discussed: vibrational, thermal, photovoltaic and RF. Of these harvesters, it shows that RF-powered WSNs have the distinct advantage over WSNs using other forms of energy harvesting that they are low cost and can operate wirelessly in a large variety of applications, even in cold, dark and static environments. Moreover, additional advantages such as utilizing a dedicated RF source for both energy harvesting as well as the generation of a reference frequency greatly reduces the complexity and power consumption of the WSN.

A co-design methodology is presented to optimize the interface between the RF energy harvester and the WSN electronics for maximum sensitivity, efficiency and output power. First, general co-design principles for antennaelectronics interfaces in the receiving mode are introduced, which includes optimum reception of wireless information and wireless power. It is shown that the choice of interface impedance plays a crucial role during the optimization procedure and that, besides maximum power transfer, the interface needs to be optimized for either voltage or current, depending on which is more favorable for the electronics. Design examples are given to, for example, improve noise figure, efficiency and sensitivity without increasing power consumption.

Based on the presented co-design principles, a CMOS rectifier and a compact loop antenna are presented for a highly sensitive RF energy harvester. A 5-stage cross-connected differential rectifier with a complementary MOS diode in the last rectifying stage is designed that significantly improves the harvesters ability to store and hold energy over a longer period of time than a conventional MOS diode. A low resistive and high-Q interface is utilized to obtain good sensitivity. To compensate variations at the interface, a control loop with a 7-bit binary-weighted capacitor bank is proposed that provides self-calibration. The chip is implemented in TSMC 90 nm CMOS technology, includes ESD protection and is directly mounted on the backside of the custom designed antenna. Measurements in an anechoic chamber at 868 MHz demonstrate an end-to-end maximum PCE of 40% and a sensitivity of -27 dBm to generate 1V across a capacitive load. In an office corridor, 1V could be generated from a 1.78 W RF source at 27 meter distance.

A high efficiency tuned switching Power Amplifier (PA) is proposed for < 0 dBm output power. It is shown theoretically that an optimum duty cycle exists for maximum drain efficiency for a given switch and effective load resistance. To set this duty cycle, an on-chip duty cycle calibration loop is proposed that fixes the duty cycle over PVT variations. A 2.4 GHz PA prototype is implemented in 40nm CMOS technology and supports On-Off Keying (OOK) modulation with pulse shaping capabilities. A global efficiency of 40% is achieved when delivering -5 dBm to a 50 W load, which compares favorably to the state-of-the-art. Due to the introduced memory in the duty cycle calibration loop, the rise and fall times are kept below 3.3 ns, making high data rate OOK modulation feasible.

The findings in this thesis have been used for the system integration of a compact RF-powered DLL-based 2.4 GHz CMOS transmitter. The received dedicated RF signal is used for both RF energy harvesting as well as frequency synthesis. An RF energy harvester with a nanowatt power management circuit harvests and subsequently monitors the energy in the storage capacitor to determine when enough energy is accumulated to initiate wireless data transmission. Once the voltage regulator and bias current circuit blocks are enabled, the incoming RF carrier is extracted and used as frequency reference. The frequency synthesizer consits of a frequency divider, Delay Locked Loop (DLL) and XOR-based frequency multiplier and thus allows for a compact integrated solution. All building blocks have been implemented in 40 nm CMOS technology and occupy only 0.16 mm2. Experimental results show a maximum rectifier efficiency of 36.83% at -11.47 dBm. In harvesting mode, the complete power management circuit only consumes 120 nA. For a 1 mF storage capacitor and -18.4 dBm minimum available power at 915 MHz RF input, the TX outputs a continuous 2.44 GHz RF signal of -2.57 dBm for 128 ms with 36.5% PA drain efficiency and 23.9% global efficiency. The complete TX consumes 1.46 mW during OOK modulation at 0.5 Mbps.

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Free Webinar on Bioelectronics and Biosensors

IMPACT and Electroceuticals: getting better with electricity

Stewart Smith, Wouter Serdijn
Oxford Global

Complimentary Registration - Bioelectronics and Biosensors Webinar

Do not miss out on the complimentary Bioelectronics and Biosensors Webinar, to be held on Wednesday 7th September 2016, 10a.m. GMT.

Can't attend the live webinar? Still register and the recording will be sent to you

This webinar is for biosensors and bioelectronics professionals and those interested in hearing about the current and future challenges in this exciting and rapidly moving industry. It is for those who are based in UK and Europe who would like to hear views from leading experts about their current research.

Featuring the first presentation on Anti-Cancer Therapy a key application for biosensor devices by Dr. Stewart Smith, from the University of Edinburgh and the second presentation on The Current Research and Applications in Bioelectronic Medicine by Professor Wouter A. Serdijn, from Delft University of Technology, the one hour webinar gives an insightful introduction to the topics covered at the forthcoming Bioelectronics and Biosensors Congress, 17-18 November 2016, London.

Click here to register for the webinar today, for free

Do you have any colleagues who may be interested in hearing this webinar? 

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Download the 2016 Bioelectronics & Biosensors Congress agenda today here

Why register to attend the Bioelectronics & Biosensors Congress?

Our event features over 35 international world-class speakers who will share their research into diagnostic sensors, nerve stimulation, implantable devices and electroceuticals.


  • Getting Better With Electroceuticals: Electronic Medicine To The Rescue. Wouter Serdijn, Professor, Delft University of Technology
  • Discovery And  Application Of Biomarkers For Biosensor Use In Infectious Disease Diagnosis. Nigel Silman, Strategic R&D Lead, Public Health England
  • Bioelectronics Technology Research At GSK. Brad Holinski, ‎Bioelectronics R&D Manager, GSK
  • Gammacore, A Hand-Held Bioelectric Device For The Treatment Of Chronic Headache Conditions. Iain Strickland, Director, Electrocore

This is a free webinar open to all, so why not sign up and benefit from the expertise of our speakers?

Contact Angela Fernandez for further information | +(44)01865 248455

Terms & Conditions: This webinar is exclusively for Bioelectronics & Biosensors professionals. If you are unsure whether you should attend please contact for clarification.
In very rare circumstances the event may be cancelled, postponed or the time changed. We will endeavour to contact you by telephone and email, it is therefore imperative that you provide the correct information. Failure to provide all the details we require on the registration form may result in your registration being cancelled.
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Biomedical Electronics Seminar

The monthly meeting of the Bioelectronics Section

MSc ME Thesis Presentation

In-vivo multicell inferior olivary recordings: alternative design methods for creating cheap and flexible electrode structures

Joost Kerpels

In order to allow neuroscientists to do in-vivo recordings on hard to reach brain tissue, such as the Inferior Olivary Complex, specially designed electrodes are required. Although a variety of electrodes are commercially available, they are usually expensive and it is hard to rapid prototype new designs.

This thesis describes the design process of three electrode array designs, each improved based on the findings of the previous one. The first design was made using a FlexPCB production technique, on which gold spots were added to create conducting measuring sites. The second design combined this technique with commercial microwire electrodes. The third design used 3d-print technology combined with microwire electrodes to create an electrode array.

All designs were tested in in vivo measurements on mice. Although successful measurements were done, the robustness and reproducibility needs to improve in order for this technique to really be applicable in a laboratory environment. Furthermore, the peripherals need to be improved in order to minimize the system to create a wearable system and perform recordings on wake animals.

Additional information ...

MSc ME Thesis Presentation

A compact multi-electrode system to measure in vivo electrical activity in the olivocerebellar system -- measuring sub-threshold oscillations and action potentials spatially and over time

Matthijs Weskin

Additional information ...

BELCA Festival

The bi-annual music festival of the Bioelectronics and Electronics groups in the /Pub at EEMCS

BELCA festival

What started out as a way to showcase the talent of faculty members in 2010 has grown into a small-scale festival, a collaboration between the Bioelectronics Department and the Electronics Research Lab. This year it's on July 1 at the Faculty of Electrical Engineering, Mathematics and Computer Science's cellar /Pub. "We'll have two external bands plus the BELCA band. As well as music there'll be dancing and shows too," said Farnaz Nassiri Nia, festival coordinator. "People are already rehearsing for their performances including some pop, jazz and Rammstein. We've tried to make it multicultural so there'll be Indian, Italian, Brazilian and Iranian songs." It's not ticketed, so you can just turn up and enjoy the show. The /Pub can accommodate 300 people.

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Beta Balie Debat: van Patient tot Cyborg

Studium Generale organiseert een Beta Balie Debat met Wouter Serdijn

Wouter Serdijn

Wouter Serdijn is Hoogleraar Bioelektronica en werkt aan miniatuur-elektronische apparaatjes die in ons lichaam communiceren met hart-, spier-, zenuw- en hersen-weefsel. Deze electroceutica zijn de elektronische tegenhangers van farmaceutica en kunnen ingezet worden om de doven te laten horen, de blinden te laten zien, de lammen te laten lopen en een groot aantal hersen-aandoeningen, zoals tinnitus (oorsuizen), epilepsie en Parkinson succesvol te behandelen. En belangrijk voordeel is dat je dit elektronische medicijn maar n maal hoeft in te nemen. Maar hoe veilig is dit allemaal? En kunnen we behalve zieken beter maken ook niet-zieken nog beter maken? En wat is dan beter? Zou jij een bionisch oor willen hebben, of een bionisch oog? Zou jij direct met je partner willen kunnen communiceren zonder tussenkomst van spraak, gebaren, oren en ogen? Zou jij een cyborg willen worden?

Wouter wil met jullie in debat over de mogelijkheden van electroceutica, gebruik en misbruik en of er ergens een grens t.a.v. de mate van supermenselijkheid te trekken valt.

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Bioelectronics group meeting

The monthly meeting of the Section Bioelectronics

Joost Kerpels; Ernesto Gonzales Huaman

Inaugural Speech Wouter A. Serdijn

Beter worden met elektroceutica -- elektronische medicijnen reiken de helpende hand

Wouter Serdijn

This inaugural speech will be spoken in Dutch. However, the presentation material will be in English or with English subtitles.

The symposium that precedes the inaugural speech will be in English.

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Symposium: Bioelectronics meets Electrophysiology

Johan Frijns (LUMC), Jeroen Dudink (ErasmusMC), Richard Houben (AB-Sys), Freek Hoebeek (ErasmusMC), Dirk Ridder (Otago Univ.)

On the occasion of Wouter Serdijns recent appointment to full professor in bioelectronics and the inaugural ceremony in which he accepts his appointment, a full-day symposium will be organized. This symposium addresses bioelectronics from a technological, a medical, a clinical, an industrial and a societal perspective. Five distinguished speakers from the Erasmus and Leiden Medical Centers, from the Dunedin School of Medicine and from Applied Biomedical Systems will address these challenging topics.

The symposium language will be English and free of charge. Registration is required, though. Please click the following link to register: Registration


9:30 hrs: registration and coffee  
10:00 hrs: opening of the symposium by the chairman, Marijn van Dongen  
10:10 hrs: Johan Frijns, Leiden University Medical Center, ENT Cochlear Implants: Clinical problem, technical solution and social impact
10:40 hrs: Dr. Jeroen Dudink, Erasmus Medical Center, Neonatology The future of baby brain monitoring
11:10 hrs: Ing. Richard Houben, Applied Biomedical Systems Electroanatomical Mapping of Persistent Atrial Fibrillation
11:40 hrs: coffee break  
12:10 hrs: Dr. Freek Hoebeek, Erasmus Medical Center, Neuroscience Bioelectronics allow the small brain to conquer the big brain
12:40 hrs: Prof.dr. Dirk de Ridder, Dunedin School of Medicine, New Zealand

Bioelectronics controls the brain by mimicking nature

13:10 hrs: lunch  
15:00 hrs: inaugural ceremony and speech of Wouter Serdijn, Delft University of Technology

Beter worden met elektrceutica: elektronische medicijnen reiken de helpende hand

(Eng: Getting Better with Electroceuticals: electronic medicine to the rescue)

16:30 hrs reception+  


ExG taskforce

Samprajani Rout; Ide Swager; Matthijs Weskin

Bioelectronics Paper Club

Bioelectronics Paper Club

Samprajani Rout

The weekly paper club of the Section Bioelectronics

Bioelectronics Colloquium

Ali Kaichouhi, Renato Borges, Yao Liu

The monthly meeting of the Bioelectronics Section

Bioelectronics/ELCA Christmas Lunch

The annual Christmas lunch with international dishes prepared by MSc and PhD students

Paper Club

The weekly paper club of the Section Bioelectronics, in which we discuss a paper of special interest to the group

Vasiliki Giagka

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EE Lunch Lecture (in Dutch)

Beter worden met electroceutica: implanteerbare en injecteerbare elektronica reiken de helpende hand

Wouter Serdijn

De 21e eeuw zal de eeuw worden waarin we ons brein zn geheimen zullen ontfutselen en waarin we het gebruik van elektriciteit zullen benutten om beter met onze elektro-chemische hoofdcomputer te interageren. In deze lunchlezing zal ik uitleggen hoe electroceutica, de elektronische tegenhangers van farmaceutica, kunnen helpen om neurologische stoornissen beter te behandelen. Verder zal ik een technologisch perspectief schetsen voor hun toekomstige ontwikkeling door electroceutica kleiner, energiezuiniger en intelligenter te maken.

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Paper Club

The weekly paper club of the Section Bioelectronics, in which we discuss a paper of special interest to the group

Gustavo Martins

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Bioelectronics group meeting

The monthly meeting of the Section Bioelectronics

Ernesto Gonzales Huaman, Farnaz Nassiri Nia, Ali Kaichouhi

PhD thesis defence Wannaya Ngamkham

Analog Integrated Circuit and System Design for a Compact, Low-Power Cochlear Implant

Wannaya Ngamkham

Cochlear Implants (CIs) are prosthetic devices that restore hearing in profoundly deaf patients by bypassing the damaged parts of the inner ear and directly stimulating the remaining auditory nerve fibers in the cochlea with electrical pulses. This thesis describs the electronic circuit design of various modules for application in CIs in order to save area, reduce power consumption and ultimately move towards a fully implantable CI.

To enhance the perception of tonal languages (such as Thai and Chinese) and music, an effort to realize the speech processor in a CI that imitates the inner hair cells and the auditory nerve behaviour more precisely should be made. According to recent physiological experiments, the envelope and phase of speech signals are required to enhance the perceptive capability of a CI implanted patient. The design of an analog complex gammatone filter is introduced in order to extract both envelope and phase information of the incoming speech signals as well as to emulate the basilar membrane behavior. A subthreshold Gm−C circuit topology is selected in order to verify the feasibility of the complex gammatone filter at very low power operation.

Several speech encoding strategies like continuous time interleaved sampling (CIS), race-to-spike asynchronous interleaved sampling (AIS), phase-locking zero-crossing detection (PL-ZCD) and phase-locking peak-picking (PL-PP) are studied and compared in order to find a compact analog speech processor that allows for full implantation and is able to convey both time and frequency components of the incoming speech to a set of electrical pulse stimuli. A comparison of the input and reconstructed speech signals in terms of correlation factor and hardware complexity pointed out that a PL-PP strategy provides a compact solution for the CI electronic hardware design since this strategy does not require a high precision envelope detector. A subthreshold CMOS peak-instant detector to be used in a PL-PP CI processor has been designed. Circuit simulations, using AMIS 0.35 􀀀m technology, show that the proposed detector can be operated from a 1.2 V supply and consumes less than 1 􀀀W static power for detecting a 5 kHz input signal. The output signal of the detector together with the input signal amplitude (the output of the band-pass of each channel) is expected to be used as control parameters in a stimulator for cochlear apical electrodes.

To design stimulators that are implanted inside the body, there are very strict requirements on the size and power consumption. Therefore, it is important to convey as much charge as possible into the tissue while using an as low as possible supply voltage to minimize power consumption. A novel method for maximizing the charge transfer for constant current neural stimulators has been presented. This concept requires a few additional current branches to form two feedback loops to increase the output resistance of a MOS current mirror circuit that requires only one effective drain-source voltage drop. The main benefit we achieve for neural stimulation is the larger amount of charge that can be conveyed to the stimulation electrode. In other words, for the same amount of charge required, the supply voltage can be reduced. Also, a compact programmable biphasic stimulator for cochlear implants has been designed by using the the above concept and implemented in AMS 0.18 􀀀m high-voltage CMOS IC technology, using an active chip area of only 0.042 mm2. Measurement results show that a proper charge balance of the anodic and cathodic stimulation phases is achieved and a dc blocking capacitor can be omitted. The resulting reduction in the required area enables many stimulation channels on a single die.

As the work laid out in this thesis produced only stand-alone modules, future work should focus on combining all these modules together to form an analog CI processor suitable for a fully implantable cochlear implant.

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Paper Club

The weekly paper club of the Section Bioelectronics, in which we discuss a paper of special interest to the group

Renato Borges

Paper Club

The weekly paper club, in which we discuss one paper of special interest to the group

Wouter Serdijn

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International Symposium on Bioelectronics and Bioinformatics

Getting better with electroceuticals: implantable and injectable electronics to the rescue

Wouter Serdijn

The 21st century will be the century in which we will unravel the intricacies of the brain and in which we will use electricity to interact with our electro-chemical mainframe better. In this talk Prof. Serdijn will explain how electroceuticals, the electronic counterparts of pharmaceuticals, can help to successfully treat neurological disorders. Further, he will sketch a technological avenue of their future development by making electroceuticals smaller, more energy efficient and more intelligent. Examples will be given for fully-implantable bionic ears and neurostimulators for the treatment of tinnitus, Tourettes syndrome and epilepsy.

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Bioelectronics Group meeting

The monthly meeting of the Section Bioelectronics

Gustavo Martins, Ide Swager, Renato Borges

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Microelectronics Colloquium

Extreme Electronics

Fabio Sebastiano, Vasiliki Giagka, Daniele Cavallo

Please Register if you want to join the colloquium.
During the Microelectronics Colloquium "Extreme Electronics". Three new Assistant Professors (Tenure Tracker) of the Microelectronics Department will present a lecture in this context.

This will be a good occasion to meet the new staff members and learn about their research. There will be a drink afterwards as well.

Vasiliki Giagka - Active Implantable Microsystems
Implantable devices have been part of our lives for many decades now. The understanding of the electrical properties of the transmitted signals in our bodies have given researchers ideas on how to interface with them by using electronics. The concept of active implants refers to the miniaturisation of the electronics and their integration into microsystems suitable to live in our bodies. These devices can be employed to write signals to the body, inhibit undesired functionality for target organs, or read signals that convey the intention of our organism. This talk will focus on presenting some of the main applications and possibilities of active implants, and will discuss the challenges related to implantable microsystems, through the example of the design, fabrication and evaluation of a stimulating active electrode array for rehabilitation of walking after spinal cord injury

Daniele Cavallo - Towards the implementation of Integrated,On Chip Terahertz Systems
Terahertz (THz) sources and detectors have been developed in the last years for applications such as space observation, spectroscopy and security screening. However, until now, the components for making such THz systems have been very bulky and pricey, and thus not suitable for cost-driven commercial applications of THz technology. In the next years, my research will be focused on the development of low-cost, efficient and highly-integrated THz systems. On the one hand, the rapid scaling of CMOS and SiGe BiCMOS will eventually enable the realization of low-cost THz electronics. On the other hand, a careful co-design of the electronic circuit, the antenna and the quasi-optical system is crucial to bring real advances in this field. An overview on the ongoing research activities on integrated THz transceivers will be presented, with emphasis on novel solutions to improve the efficiency of on-chip antennas.

Fabio Sebastiano - Cryogenic CMOS for Quantum Computers
Quantum computers hold the promise to change our everyday lives in this century in the same radical way as the classical computer did in the last century, by efficiently solving problems that are intractable today, such as large number factorization and simulation of quantum systems. Quantum processors must be cooled at cryogenic temperatures well below 1 K and each of their quantum bits (qubit) must be controlled by a classical electronic interface. Since future quantum processors with practical applications will require up to thousands or millions of quantum bits (qubit), the electronic controller must operate at cryogenic temperatures as close as possible to the quantum processor, to avoid the unpractical requirement of thousands of cables from the cryogenic refrigerator to a room-temperature controller. This talk will address the challenges of building such a scalable silicon-based cryogenic electronic controller, focusing on to use standard CMOS technology to build complex analog and digital systems and circuits operating down to 4 K and below.

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PhD thesis defence Yongjia Li

Level-Crossing ADCs and their Applications in Biomedical Readout Systems

Yongjia Li

Chapter 1 introduces the background of the thesis topic. The basic knowledge of level-crossing sampling is described. In a wireless sensor node, the system power consumption is usually dominated by the wireless power transmission. Reducing the data size is crucial to save system power consumption under such circumstances. Therefore, a comparison between conventional uniform sampling and level-crossing sampling is made in terms of sampling data size. For low resolution (< 7 bits) in amplitude, LC-ADCs generate fewer samples than uniform-sampling ADCs for various biomedical signals (ECG, EEG, EMG, ECoG). Furthermore, the design challenges and motivation of realizing a level-crossing sampling based readout system are described.

Chapter 2 reviews and analyzes previously reported LC-ADCs from different aspects. Based on various window detection methods and feedback DACs, LC-ADCs are classified into various groups. Advantages and disadvantages of each structure are discussed. Since LC-ADCs work in the continuous-time domain without a clock, conventional offset cancellation topologies are not applicable. Therefore, LC-ADCs with automatic onchip offset calibration are reviewed. Moreover, LC-ADCs with various system applications are discussed.

Two standalone level-crossing ADCs for biomedical applications are presented in Chapter 3 and Chapter 4, respectively. A single-bit charge accumulation DAC is proposed to save power consumption while relaxing the settling time requirement. Asymmetrical window detection allows the two comparators to consume power more efficiently without sacrificing performance. Innovations at both system level and circuit level pave the way to low-power operation for the LC-ADC. The circuits have been designed and fabricated in AMS 0.18 mm CMOS IC technology. Compared to other LC-ADCs, lower power consumption and less design complexity have been achieved due to the proposed topologies. The event-driven nature makes the proposed ADC very suitable for biomedical applications.

Chapter 5 presents the system integration of an LC-ADC. An ECG recording system with level-crossing sampling is proposed. The system is a voltage and current mixed-mode system. The LNA with fully balanced pseudo-resistors provides good linearity. Resolving the input signal further in the current domain allows for a large dynamic range while operating from a low-voltage supply, avoids leakage and offers more design flexibility. The use of a current feedback DAC eases the integration of calibration blocks in the continuous-time domain. The circuit has been designed and fabricated in a 0.18 μm CMOS IC technology. The proposed system is also very suitable for other biomedical applications where the signals are sparse.

In the final chapter, the thesis is summarized and concluded. The measurement results confirm the effectiveness of the techniques presented in this thesis. Last but not least, possible improvements and research fields that are related to this work are discussed. Suggestions for future work are made.

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Microelectronics Colloquium

Remotely powered sensor networks and RFIDs for medical and telecoms applications

Catherine Dehollain
EPFL Lausanne, RFIC Group, Switzerland

Remotely powered systems are used in a lot of different applications, and in particular in the medical and telecoms fields. The main principle of remote powering is to get energy by magnetic, electro-magnetic or electro-acoustic coupling between the sensor node and the base station. Each scenario of use implies a custom-design approach due to the fact that the distance of operation between the sensor node and the base station as well as the maximum targeted volume of the sensor node dictate the choice of the frequency for remote powering and for data communication. Moreover, one single frequency approach for which the same frequency is used for remote powering and data transmission has to be compared to a two frequency solution by taking into account the data rate for communication as well as the power consumption of the sensor node. All these different aspects will be discussed in this talk by starting from a system level approach down to the transistor implementation including the design of the antennas.

Professor Catherine Dehollain received the Degree in electrical engineering in 1982 and the Ph.D. degree in 1995 from EPFL. From 1982 to 1984, she was a Research Assistant at the Electronics Laboratories (LEG), EPFL. In 1984, she joined the Motorola European Center for Research and Development, Geneva, Switzerland, where she designed integrated circuits applied to telecommunications. In 1990, she joined EPFL as a Senior Assistant at the "Chaire des Circuits et Systemes," where she was involved in impedance broadband matching. Since 1995, she has been responsible for the EPFL-RFIC Group. She has a large experience in CMOS analog and RF circuits design as well as in the design of antennas, coils and transformers. She has participated to different European FP6 and FP7 projects. She has been the project leader of the Swiss CAPED project dedicated to the design of a capsule for the tracking motility in the gastrointestinal (GI) tract. She has been the coordinator of the FP7 UltraSponder project dedicated to the design of a remotely powered sensor by using ultrasonic waves to monitor the heart health conditions. She is involved in different biomedical projects and wireless communication projects.

Bioelectronics Colloquium

The monthly meeting of the Bioelectronics Group

Farnaz Nassiri Nia; Samprajani Rout; Alessandro Urso; Gustavo Campos

Literature Colloquium by Farnaz, Presentations by Samprajani and Alessandro and BMI demo by Gustavo.

MSc BME Thesis Presentation

Application of Ultrasound to Remove Thrombi from a Left Ventricular Assist Device (LVAD)

Arundhati Radhakrishnan

Due to limited number of donor hearts and stringent eligibility criteria for heart transplant the Left ventricular assist device (LVAD) has emerged as a relevant treatment option for heart failure. Occlusion in the form of a thrombus (blood clot) is a feared complication associated with the LVAD. The ability of ultrasound to result in effects like cavitation, which is hypothesized to be one of the mechanisms contributing to sonothrombolysis(ultrasound mediated thrombolysis) forms the basis of proposing a solution wherein ultrasound is used to remove thrombi from the LVAD. The proposed solution entails catheter delivery of ultrasound into the LVAD to break down the thrombus.

In this master thesis an experimental setup to conduct sonothrombolysis tests on in vitro clots has been realized. In order to understand the mechanism contributing to a high degree of sonothrombolysis a commonly used method - passive cavitation detection is also employed. In the final experiments sonothrombolysis and passive cavitation detection tests are conducted on two sets of 6 clots each. For majority of the clots, sonothrombolysis occurs at a peak negative pressure of 2.71MPa - 3.18 MPa. Clots which underwent a high degree of sonothrombolysis were always accompanied by high counts and violent movement. We assume the intermittent spikes termed as cavitation events being counted are due to physical effects like inertial bubble collapse, shockwaves and microjets, which are characteristic of inertial cavitation. Hence we can conclude that the high counts are indicative of inertial cavitation and play a dominant role in achieving a high degree of sonothrombolysis. The results of this master thesis provide experimental evidence as to why a certain threshold of peak negative pressure must be attained in order to achieve a high degree of sonothrombolysis. This evidence can be utilized in the next step of catheter design. At this stage it can be said that the application of ultrasound to remove thrombi from the LVAD will prove to be successful if high intensity ultrasound resulting in inertial cavitation can be delivered to the site of the thrombi formation in the LVAD.

MSc thesis presentation Sander Fondse

Sleeping Wireless Energy Transfer and Trickle Charging

Sander Fondse

In a world of improving health care, some diseases are still very hard to diagnose. The most common reasons for this problem is the fact that those diseases are non-symptomatic. To gain better diagnoses of such illnesses long term ExG by using bio-medical implants is a good option. These implants have to be powered by a wireless power link. This thesis analyses the possibilities for the development of a wireless transfer system that can transfer at least 360 Wh of energy within six hours through the air and into tissue tissue. After analysis of the influence of the environment on the wave efficiency it is proven that resonant magnetic transfer is the best option for the given scenario. 13.56 MHz is chosen as operating frequency. Energy for the implant is needed at DC level, therefore a rectifier layout is analysed, designed and built out of discrete parts. With the use of discrete components and hand-made inductors, the final operating frequency became 17.50 MHz. The laboratory equipment used restricted the maximum input voltage amplitude to 4.56 V. The final result of this thesis is a prototype wireless energy transfer system that generates a maximum of 75.9 W of power continuously at a power efficiency of 10.1 percent at a distance of 15 mm.At a distance of 75 mm, the maximum output power was still equal to 2 W. The power efficiency at 75 mm distance is equal to 0.29 percent, which means that to generate 360 Wh within six hours the input power must be at least 25.9 mW, a value that can easily be reached without causing flicting damage to human tissue or the system itself. This proves that magnetically coupled inductor systems can be used for the future development of autonomous ExG implants.

MSc thesis presentation Thanas Karapatis

Next-generation neuromodulator for epilepsy prevention

Athanasios Karapatis

Closed-loop neurostimulation systems have emerged as a prominent method for treating seizures. However, most of the proposed solutions do not consider the need for fast (real-time) seizure detection or their energy overheads, resulting in systems not suitable for wearable or implantable applications. This thesis describes the design and implementation of a novel closed-loop system that is capable of real-time seizure detection and suppression, while requiring minimal power and energy consumption. The proposed system utilizes a complex Morlet wavelet in combination with a thresholding mechanism to detect the presence of ictal-activity in ECoG signals. We evaluate our system in terms of detection performance (sensitivity, specificity and delay) considering various filter parameters, such as the filter order and various (static) detection thresholds. Additionally, we consider the systems suitability for implantable applications by evaluating its computational overheads (execution time, energy consumption) when executed on the SiMS low-power processor. We show that decreasing the filter order results in less accurate detection (sensitivity, specificity), a faster detection (delay), and less overheads. In addition, we show that we may further improve the detection accuracy and delay with minimal overheads by considering an input-dependent (adaptive) threshold mechanism. Furthermore, we show that we can effectively trade-off detection accuracy and energy consumption: For example, shrinking filter order by 70% results in a decrease in detection accuracy of only 1%, while allowing us to obtain an improvement in delay by 190 ms (from 710 ms to 520 ms) and in energy consumption by 70% (from 5.04uJ to 1.51uJ). Compared to related work, we show that we can detect seizures significantly faster (492 ms, compared to 970 ms) with the same sensitivity (94%) and at a minimal decrease in specificity of 4.6% (93.60% compared to 98.2%). A prototype implementation of the closed-loop system has successfully been applied in in-vivo experiments, demonstrating its potential for epilepsy treatment.


Circuits and Systems for Electroceuticals

Wouter Serdijn

Invited talk at the 47th annual meeting of the Associazione Gruppo Italiano di Elettronica (GE Association)

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John Choma Commemorative Session: invited talk

Power-efficient Neural Stimulator Circuits

Wouter Serdijn

John Choma Commemorative Special Session 1:
Reconfigurable and Adaptive Analog, Mixed-Signal, and Radio-Frequency Integrated Circuits

Session Chair: David Allstot

David AllstotDavid J. Allstot received the B.S. (1969), M.S. (1974), and Ph.D. (1979) degrees from the Univ. of Portland, Oregon State Univ. and the Univ. of California at Berkeley, respectively. He has held several industrial and academic positions. He was a Professor of Electrical Enginering at the University of Washington from 1999 to 2012. In 2000, he was appointed as the Boeing-Egtvedt Chair Professor of Engineering. He served as Acting Chair and Chair of Electrical Engineering from 2004 to 2007. He has advised more than 100 M.S. and Ph.D. graduates. He served as Editor of the IEEE Transactions on Circuits and Systems, General Co-Chair of the 2002 and 2008 IEEE Intl. Symp. on Circuits and Systems, and as the 2009 President of the IEEE Circuits and Systems Society. He is a Fellow of IEEE.

Invited Speakers:

  1. Yannis Tsividis: Circuits with Adaptive Power Dissipation
    Yannis TsividisYannis P. Tsividis is Charles Batchelor Professor of Electrical Engineering. Starting with the first fully integrated MOS operational amplifier, which he demonstrated in 1976, he has done extensive work in analog and mixed-signal integrated circuits at the device, circuit, system, and computer simulation level. He and his students have been responsible for several contributions, ranging from precision device modeling and novel circuit building blocks to new techniques for analog and mixed-signal processing, self-correcting chips, switched-capacitor network theory, RF integrated circuits, mixed analog-digital VLSI computation and the creation of computer simulation programs. This work has resulted in several patents in several countries. He is the recipient of the 1984 IEEE W. R. G. Baker Prize Award for the best IEEE publication, the 1986 European Solid-State Circuits Conference Best Paper Award, and the 1998 and 2008 IEEE Circuits and Systems Society Guillemin-Caure Best Paper Award. He is co-recipient of the 1987 IEEE Circuits and Systems Society Darlington Best Paper Award and the 2003 IEEE International Solid-State Circuits Conference L. Winner Outstanding Paper Award. He is a fellow of the IEEE, and received a Golden Jubilee Medal from the IEEE Circuits and Systems Society in 2000. At Columbia, he has received the 1991 Great Teacher Award from the Alumni Association, the 1998 Distinguished Faculty Teaching Award from the Engineering School Alumni Association, and the 2003 Presidential Award for Outstanding Teaching. He received the IEEE Undergraduate Teaching Award in 2005, and the IEEE Gustav Robert Kirchhoff Award in 2007.
  2. Franco Maloberti: Adaptability and Configurability of Data Converters for Nano-meter Technologies
    Franco MalobertiFranco Maloberti received the Laurea degree in physics (summa cum laude) from the University of Parma, Parma, Italy, in 1968, and the Doctorate Honoris Causa in electronics from the Instituto Nacional de Astrofisica, Optica y Electronica (Inaoe), Puebla, Mexico, in 1996. He was a Visiting Professor at The Swiss Federal Institute of Technology (ETH-PEL), Zurich, Switzerland and at the EPFL, Lausanne, Switzerland. He was the TI/J.Kilby Chair Professor at the A&M University, Texas and the Distinguished Microelectronic Chair Professor at the University of Texas at Dallas. Presently he is Professor of Microelectronics and Head of the Micro Integrated Systems Group, University of Pavia, Italy. His professional expertise is in the design, analysis, and characterization of integrated circuits and analog digital applications, mainly in the areas of switched-capacitor circuits, data converters, interfaces for telecommunication and sensor systems, and CAD for analog and mixed A/D design. He has written more than 500 published papers on journals or conference proceedings, four books, and holds 34 patents. Dr. Maloberti was the recipient of the XII Pedriali Prize for his technical and scientific contributions to national industrial production, in 1992. He was co-recipient of the 1996 Institute of Electrical Engineers Fleming Premium, the best Paper award, ESSCIRC-2007, and the best paper award, IEEJ Analog Workshop-2007 and 2010. He was the President of the IEEE Sensor Council from 2002 to 2003 and Vice-President, Region 8, of the IEEE CAS Society from 1995 to 1997 and an Associate Editor of IEEE TCAS-II. He was serving as VP-Publications of the IEEE CAS Society 2007-2008. He was distinguished lecturer of the IEEE Solid State Circuits Society 2009-2010 and distinguished lecturer of the Circuits and Systems Society 2012-2013. He received the 1999 IEEE CAS Society Meritorious Service Award, the 2000 CAS Society Golden Jubilee Medal, and the 2000 IEEE Millennium Medal. He received the IEEE CAS Society 2013 Mac Van Valkenburg Award. He is an IEEE Fellow. In 2009 he received the title of Honorary Professor of the University of Macau and he is currently the chairman of the Academic Committee of the Microelectronics Key-Lab of Macau. He is President elect of the IEEE Circuits and Systems Society.
  3. Edgar Sanchez-Sinencio: 150650 MHz Low Distortion Inverter-based Adaptive Sine-wave Synthesizer
    Edgar Sanchez-SinencioResearch Interests: Design and implementation of mixed-signal processing circuits and systems; Power Management; Medical and Environmental Applications; RF Communication Circuits. Awards and Honors: IEEE Fellow (1992); Halliburton Professorship, College of Engineering, Texas A&M University (1993); IEEE Guillemin-Cauer Award (1995);
    Honoris Causa Doctorate awarded by the National Institute for Astrophysics, Optics, and Electronics (INAOE), Mexico, November (1995); Texas Senate Proclamation #373 for Outstanding Accomplishments; IEEE Darlington Award (1997); Texas Instruments Analog Engineering Chair Professor Holder, College of Engineering, Texas A&M University. (March 1999 – January 2002); William & Ruth Neely/ Dow Chemical Faculty Fellow (2000-2001) Engineering Program Texas A&M University; IEEE Circuits and Systems Society Golden Jubilee Medal Recipient (May 2000); Texas Instruments/ Jack Kilby Chair Professor Holder, College of Engineering, Texas A&M University (February 2002-Present); IEEE Circuits and Systems Society Technical Achievement Award (May 2008); Outstanding Professor Award (2011); IEEE Circuits and Systems Society Distinguished Lecturer (2012-2013). Education: Ph.D. University of Illinois, Champaign-Urbana (1974); M.S. Stanford University, Stanford California (1970); B.S. National Polytechnic Institute of Mexico (1965).
  4. Hossein Hashemi: Reconfigurable radio-frequency receivers
    Hossein HashemiHossein Hashemi received the B.S. and M.S. degrees in electronics engineering from Sharif University of Technology, Tehran, Iran in 1997 and 1999, respectively, and the M.S. and Ph.D. in electrical engineering from the California Institute of Technology (Caltech), Pasadena, CA in 2001 and 2003, respectively. He received Caltech engineering and applied science division fellowship award in 1999, Walker von Brimer Foundation Outstanding Accomplishment Award in 2000, Analog Devices Outstanding Student Designer Award in 2001, Intel Foundation Graduate Fellowship Award in 2002 and the Young Scholar Award from Association of Professors and Scholars of Iranian Heritage (APISH) in 2003.
  5. Randy Geiger: On-Chip Thermal Management for Reliable Integrated Circuits
    Randy GeigerRandy Geiger received the BS degree in electrical engineering and the MS degree in mathematics from the University of Nebraska and the PhD degree in electrical engineering from Colorado State University. From 1977 to 1990 he was a faculty member in the Electrical Engineering Department at Texas A&M University and since 1991 he has been a member of the faculty in the Department of Electrical and Computer Engineering at Iowa State University where he currently holds the title Willard and Leitha Richardson Professor. He is a past president of the IEEE Circuits and Systems Society (CAS), a past chair of the Transactions Committee of the IEEE Periodicals Council, and a past member of the IEEE Publications Board. He was the recipient of the IEEE Millennium Medal and the IEEE CAS Society Golden Jubilee Award, and is a Fellow of the IEEE.

John Choma Commemorative Special Session 2:
Ultra-Low-Power Integrated Circuits and Systems for Biomedical Implants

Session Chair: Hossein Hashemi

Hossein HashemiHossein Hashemi received the B.S. and M.S. degrees in electronics engineering from Sharif University of Technology, Tehran, Iran in 1997 and 1999, respectively, and the M.S. and Ph.D. in electrical engineering from the California Institute of Technology (Caltech), Pasadena, CA in 2001 and 2003, respectively. He received Caltech engineering and applied science division fellowship award in 1999, Walker von Brimer Foundation Outstanding Accomplishment Award in 2000, Analog Devices Outstanding Student Designer Award in 2001, Intel Foundation Graduate Fellowship Award in 2002 and the Young Scholar Award from Association of Professors and Scholars of Iranian Heritage (APISH) in 2003.

Invited Speakers:

  1. Mohamad Sawan: ISFET-based Biosensors for Extracellular pH Gradient Monitoring
    Mohamad SawanProfessor Mohamad Sawan received the B.Sc. degree in electrical engineering from Universit Laval, Quebec, Canada in 1984, the M.Sc. and Ph.D. degrees, both in electrical engineering, from Universit de Sherbrooke, Canada, and post-doctorate from McGill University, Montral, Canada. He joined Ecole Polytechnique de Montral in 1991 where he is currently a Professor in Microelectronics and Biomedical Engineering. Dr. Sawans scientific interests are the design and test of mixed-signal (analog, digital and RF) circuits and systems, signal processing, modeling, design, integration, assembly and validation of sensing techniques, laboratory-on-chip devices including micro and nanotechnology processing. These topics are oriented toward the implantable medical devices and diagnostic tools. Dr. Sawan is an honorary professor at Shanghai Jiao Tong University , China, and was four times a visiting scientist at University of Metz, France.
    Early in 2000, Dr. Sawan made headlines with what could be called his ”bionic vision.” He had invented an eye implant to enable completely blind people to gain or regain some sight. A leader in the development of intelligent medical devices, his research helps to alleviate the adverse effects of blindness, urological dysfunction, paralysis, deafness and other problems. The invention that has brought his work to the public’s attention is a visual cortical stimulator that operates using a tiny camera. The device is installed on a pair of glasses and transmits images to a controller in the wearer’s pocket. A device in the controller then transmits radio signals to a microstimulator implanted in the visual cortex of the brain, thus enabling a blind person to make out shapes.
    Dr. Sawan is a holder of a Canadian Research Chair (CRC) in Smart Medical Devices. As a CRC, Dr. Sawans studies all the processes involved in creating intelligent medical devices, from the design to the clinical trial stage. He also contributes to artificial legs control by an RF signal coming from an implantable ENG recording microsystem, and to bladder control (retention and voiding) in spinal-cord injured patient. Licenses of three of Dr. Sawans medical devices were awarded to local industries for the evaluation on humans. Dr. Sawan is Founder and Director of Polystim Neurotechnologies Laboratory, and The Microsystems Strategic Alliance of Quebec (ReSMiQ), a multi-university research center regrouping 10 main Universities in Quebec dealing with Microsystems activities. He is founder of the Eastern Canadian IEEE-Solid State Circuits Society Chapter, the International IEEE NEWCAS Conference. He is cofounder of the International Functional Electrical Stimulation Society, and the International IEEE conference on Biomedical Circuits and Systems (BiOCAS). Also, he is cofounder of the BiOCAS committee in the IEEE circuits and systems society, where he was elected president for 2 years. He is cofounder and associate editor of the IEEE Transactions on BiOCAS (TBCAS). Dr. Sawan was the IEEE Circuits and systems society representative in the International Biotechnology Council committee, and he is editor and guest editor of several prestigious scientific Journals.
    Dr. Sawan published more than 400 papers in peer reviewed journals and conference proceedings, offered more than 60 invited talks/keynotes, and he was awarded 9 patents. Dr. Sawan has been elected Fellow of the Canadian Academy of Engineering and Fellow of the Engineering Institute of Canada; the most prestigious honors aspired for by Canadian Engineering researchers, and Fellow of the IEEE; the most prestigious honor aspired for by world wide Electrical Engineers. Dr. Sawan has been recipient of the Medal of Honor from the President of Lebanon for outstanding achievements, the Bombardier Award for technology transfer, and the Barbara Turnbull award, one of the most prestigious awards in biomedical research in Canada.
  2. Ralph Etienne-Cummings: Real-time Compressive Sensing in Hardware: Maximizing Communication Channel Utility in Power Impoverished Environments
    Ralph Etienne-CummingsI received my B. Sc. in physics, 1988, from Lincoln University, Pennsylvania. I completed my M.S.E.E. and Ph.D. in electrical engineering at the University of Pennsylvania in December 1991 and 1994, respectively. I have served as Chairman of the IEEE Circuits and Systems (CAS) Technical Committee on Sensory Systems and on Neural Systems and Application, and was re-elected as a member of CAS Board of Governors from 1/2007 – 1/2009. I was also the General Chair of the IEEE BioCAS Conference in 2008, and serves on its Steering Committee. I was also a member of Imagers, MEMS, Medical and Displays Technical Committee of the ISSCC Conference from 1999 – 2006. I also serve on numerous editorial boards and was recently appointed Deputy Editor in Chief for the IEEE Transactions on Biomedical Circuits and Systems. I am the recipient of the NSF’s Career and Office of Naval Research Young Investigator Program Awards. In 2006, I was named a Visiting African Fellow and a Fulbright Fellowship Grantee for his sabbatical at University of Cape Town, South Africa. I was invited to be a lecturer at the National Academies of Science Kavli Frontiers Program, held in November 2007. I won the 2010 JHU Applied Physics Lab R.W. Hart Prize for Best R&D Project in Development. I have also won publication awards, including the 2011 Best Paper Award for IEEE Transactions of Biomedical Circuits and Systems, 2003 Best Paper Award of the EURASIP Journal of Applied Signal Processing and “Best Ph.D. in a Nutshell” at the IEEE BioCAS 2008 Conference, and have been recognized for his activities in promoting the participation of women and minorities in science, technology, engineering and mathematic. In 2012, I was recognized as a “ScienceMaker”, as part of the HistoryMakers which is an African American history archive and was elected as an IEEE Fellow for contributions in “neuromorphic sensory-motor circuits and systems”.
  3. Wouter Serdijn: Power-efficient Neural Stimulator Circuits
    Wouter SerdijnWouter A. Serdijn (M’98, SM’08, F’11) was born in Zoetermeer (‘Sweet Lake City’), the Netherlands, in 1966. He received the M.Sc. (cum laude) and Ph.D. degrees from Delft University of Technology, Delft, The Netherlands, in 1989 and 1994, respectively. Currently, he is an associate professor at Delft University of Technology, where he heads the Section Bioelectronics.
    His research interests include low-voltage, ultra-low-power and ultra wideband integrated circuits and systems for biosignal conditioning and detection, neuroprosthetics, transcutaneous wireless communication, power management and energy harvesting as applied in, e.g., hearing instruments, cardiac pacemakers, cochlear implants, neurostimulators, portable, wearable, implantable and injectable medical devices and electroceuticals.
    He is co-editor and co-author of the books EMI-Resilient Amplifier Circuits (Springer 2013), Ultra Low-Power Biomedical Signal Processing: an analog wavelet filter approach for pacemakers (Springer, 2009), Circuits and Systems for Future Generations of Wireless Communications (Springer, 2009), Power Aware Architecting for data dominated applications (Springer, 2007), Adaptive Low-Power Circuits for Wireless Communications (Springer, 2006), Research Perspectives on Dynamic Translinear and Log-Domain Circuits (Kluwer, 2000), Dynamic Translinear and Log-Domain Circuits (Kluwer, 1998) and Low-Voltage Low-Power Analog Integrated Circuits (Kluwer, 1995). He authored and co-authored 8 book chapters, 2 patents and more than 300 scientific publications and presentations. He teaches Circuit Theory, Analog Signal Processing, Micropower Analog IC Design and Bioelectronics. He received the Electrical Engineering Best Teacher Award in 2001 and 2004.
    He has served, a.o., as General Co-Chair for IEEE BioCAS 2013, Technical Program Chair for IEEE BioCAS 2010 and as Technical Program Chair for IEEE ISCAS 2010, 2012 and 2014, as a member of the Board of Governors (BoG) of the IEEE Circuits and Systems Society (20062011), as chair of the Analog Signal Processing Technical Committee of the IEEE Circuits and Systems society, as a member of the Steering Committee of the IEEE Transactions on Biomedical Circuits and Systems (T-BioCAS) and as Editor-in-Chief for IEEE Transactions on Circuits and SystemsI: Regular Papers (20102011). He will be General Co-Chair for IEEE ISCAS 2015.
    Wouter A. Serdijn is an IEEE Fellow, an IEEE Distinguished Lecturer and a mentor of the IEEE.
  4. Herming Chiueh: The Development of Ulta-Low Power Mixed-Signal Processor for Epileptic Seizure Detection and Wearable-Device Applications
    Herming ChiuehHerming Chiueh received his B.S. degree from the Department of Electrophysics, National Chiao Tung University, Hsin-Chu, Taiwan in 1992, and the M.S. and Ph.D. degrees from Department of Electrical Engineering, University of Southern California, Los Angeles, in 1994 and 2002. From 1996-2002, he was with Information Sciences Institute, University of Southern California, Marina del Rey, California. Dr. Chiueh has participated the VLSI effort on several large projects in USC/ISI and most recently participated the development of a 55-million transistor processing-in-memory (PIM) chip. He is currently an Assistant Professor, Department of Electrical Engineering, National Chiao Tung University, Hsin-Chu, Taiwan. His research interests include system-on-chip design methodology, thermal management for VLSI, low-power integrated circuits, Neural interface circuits, and biomimetic systems. IEEE Services Member of the IEEE Circuits and Systems Society since 1990 Conference Finance Chair: 2007 IEEE International Workshop on Memory Technology, Design and Testing (MTDT) Technical Program Committee: Thermal Issues in Emerging Technologies, Theory and Applications (THETA2008), Thermal investigations of ICs and Systems (THERMINC 05-08) Reviewer of papers submitted to IEEE Tran. on VLSI, Microelectronic Journal and Journal of Information Technology and Applications Reviewer of papers submitted to IEEE VLSI-Symposia, IEEE TENCON, IEEE MTDT, IEEE ICECS, IEEE ISCAS, IEEE SSMSD, THERMINIC and Great Lakes Symposium on VLSI.
  5. Roman Genov: Implantable Wireless Closed-Loop Neurostimulators for the Treatment of Intractable Epilepsy
    Roman GenovRoman Genov received the B.S. degree in Electrical Engineering from Rochester Institute of Technology, NY in 1996 and the M.S.E. and Ph.D. degrees in Electrical and Computer Engineering from Johns Hopkins University, Baltimore, MD in 1998 and 2003 respectively.
    Dr. Genov held engineering positions at Atmel Corporation, Columbia, MD in 1995 and Xerox Corporation, Rochester, NY in 1996. He was a visiting researcher in the Laboratory of Intelligent Systems at Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland in 1998 and in the Center for Biological and Computational Learning at Massachusetts Institute of Technology, Cambridge, MA in 1999. He is presently an Associate Professor in the Department of Electrical and Computer Engineering at the University of Toronto, Canada, where he is a member of Electronics Group and Biomedical Engineering Group and the Director of Intelligent Sensory Microsystems Laboratory.
    Dr. Genovs research interests are primarily in analog integrated circuits and systems for energy-constrained biological, medical, and consumer sensory applications, such as implantable, wearable or disposable sensory microsystems, energy-efficient sensory signal processors and wireless sensors, including brain-chip interfaces, neuro-stimulators, image sensors, optical and electro-chemical DNA microarrays, and other biosensors.
    Dr. Genov is a co-recipient of Best Paper Award of IEEE Biomedical Circuits and Systems Conference, Best Student Paper Award of IEEE International Symposium on Circuits and Systems, Best Paper Award of IEEE Circuits and Systems Society Sensory Systems Technical Committee, Brian L. Barge Award for Excellence in Microsystems Integration, MEMSCAP Microsystems Design Award, DALSA Corporation Award for Excellence in Microsystems Innovation, and Canadian Institutes of Health Research Next Generation Award. He was a Technical Program Co-chair at IEEE Biomedical Circuits and Systems Conference. He was an Associate Editor of IEEE Transactions on Circuits and Systems-II: Express Briefs and IEEE Signal Processing Letters. Currently he is an Associate Editor of IEEE Transactions on Biomedical Circuits and Systems and member of IEEE International Solid-State Circuits Conference International Program Committee serving in Imagers, MEMS, Medical, and Displays (IMMD) Subcommittee and in Demonstrations Subcommittee.
  6. Additional information ...

ISCAS 2015

IEEE International Symposium on Circuits and Systems

Queridos amigos,

On behalf of the Organizing Committee, we are pleased and honored to invite and welcome you to Lisbon and to the 2015 IEEE International Symposium on Circuits and Systems (ISCAS 2015). The conference theme, Enabling Technologies for Societal Challenges, in line with the 2020 European Research and Innovation Roadmap and the Grand Engineering Challenges, suits extremely well our communitys inter-disciplinary and cross-disciplinary research activities.

ISCAS is the main event of the IEEE Circuits and Systems Society and the worlds premier networking forum for leading researchers in the highly active fields of theory, design and implementation of circuits and systems. The Technical Program Co-Chairs for this year edition, Joo Goes and Philipp Hfliger, have assembled an outstanding program with three full days of lectures and poster sessions covering 16 tracks. The most outstanding contributions to these tracks will be considered for the Best Student Paper Award contest and the Best Live Demo Award contest. The winners of both awards will be selected and announced during the conference.

ISCAS 2015 also offers high-quality and leadingedge tutorials and special sessions from worldwide experts, either in specific and in multidisciplinary areas, suited for those looking for a birds-eye view on a new research area or to improve their areas of expertise. A set of world-class keynote speeches is being prepared and will be announced soon.

Apart from the scientific contributions, ISCAS 2015 will offer a forum that promotes the interaction between industry, start-ups, PhD students, academia and research funding agencies. This interaction will have place through industry presence, debates and talks.

ISCAS 2015 maintains the Women in CAS (WiCAS) activity as well as the Young Professionals Program (YPP) activity and will also host a Conference Leadership Workshop, a Special John Choma Commemorative Session with 10 distinguished invited speakers and other events, further enriching the technical program.

As for the social program we will try to match the quality of the technical program and of the tutorial offerings. On Tuesday, the Award Ceremony will be held in an opera house auditorium followed by the Gala Dinner in the Convento do Beato, a magnificent former monastery that dates back to the 15th century.

ISCAS 2015 will assist in sharing and disseminating your specific and inter- and cross-disciplinary technical achievements and will bring together diverse participants, histories and cultures. We look forward to your active participation in this magnificent event!

Um abrao, Jorge Fernandes and Wouter Serdijn General Chairs

Additional information ...

PhD thesis defence

Design of efficient and safe neural stimulators - a multidisciplinary approach

Marijn van Dongen

Neural stimulation is an established treatment methodology for an increasing number of diseases. Electrical Stimulation injects a stimulation signal through electrodes that are implanted in the target area of the central or peripheral nervous system in order to evoke a specific neuronal response that suppresses or treats pathological activity. This thesis discusses the design of neural stimulators: the device that is responsible for generating the stimulation signal in a safe, efficient and controlled manner. The design of such a device requires a highly multidisciplinary approach which involves disciplines such as neuroscience, electrophysiology, electrochemistry and electrical engineering.
The first part of this thesis focuses on the processes associated with the neuronal recruitment. After describing the stimulation processes in detail at various levels, the discussion zooms in on the processes at the electrode-tissue interface and in particular the electrochemical behavior. Many neural stimulators include coupling capacitors between the stimulator and the electrodes to reduce the risk of potentially harmful electrochemical reactions. However, it is shown that coupling capacitors also have negative implications that need to be considered, such as a shift in the equilibrium potential of the electrode-tissue interface. Also, the reversibility of charge transfer processes at the electrode-tissue interface is analyzed. Most studies rely on monitoring the electrodetissue interface potential to determine the maximum reversible charge injection limits. By measuring the reversible charge in a more direct way, it was found that irreversible charge transfer processes already play a role for stimulation intensities that are well below the established charge injection limits.
The extensive description of the stimulation process is furthermore used to introduce a fundamentally different stimulation paradigm. Instead of using a constant current or voltage to stimulate the electrodes, a high frequency, switched-mode stimulation signal is applied. The advantage of such a stimulation pattern is that it can be generated in a power efficient way by the neurostimulator circuit using switched-mode operation that is common in energy efficient amplifiers (class-D operation) or power management circuits. The efficacy of the proposed stimulation pattern is verified both using modeling as well as using in vitro measurements by analyzing the response of patch-clamped Purkinje cells.
The second part of the thesis focuses on the electrical design of neural stimulators. The first system is designed to be used in a specific neuroscientific experiment and features arbitrary waveform stimulation. The user has full flexibility over the choice of stimulation waveform, while the stimulator circuit guarantees safety by ensuring charge balanced operation. The stimulator circuit is realized and included in a system implementation that is suitable for the in vivo experimental setup. The stimulation pulse (which uses a burst pattern) is synchronized with auditory stimulation in an attempt to recondition the neural pathways in a mouse that suffers from tinnitus.
The second design implements the high-frequency switched-mode stimulation pattern that was introduced in the first part of the thesis. The system features an unfiltered forward buck-boost converter at its core to directly stimulate the target tissue. It is possible to operate the system with multiple independent channels that connect to an arbitrary electrode configuration, making the system well suited for current steering techniques. Furthermore, comprehensive control was implemented using a dual clock configuration that allows both autonomic tonic stimulation, as well as single shot stimulation. Each channel can be configured individually with tailored stimulation parameters and multiple channels can operate in a synchronized fashion. The system is power efficient, especially when compared with state-of-the-art constant current stimulators with an adaptive power supply that operate in multichannel mode. Efficiency improvements up to 200% compared with state of the art constant current stimulators are demonstrated. Furthermore, the number of external components required is reduced to a single inductor.

Additional information ...

Bioelectronics Colloquium

The future of brain, spine and nerve stimulation

Prof. Dirk de Ridder, MD PhD
Dunedin School of Medicine, University of Otago, New Zealand


Invasive neuromodulation of the central and peripheral nervous system is still in its infancy, but recently the advent of burst stimulation and high frequency stimulation (10 kHz) have shown that results of neurostimulation can be improved not only by more accurate targeting but also by communicating to the nervous system in other languages, i.e. by using other stimulation designs.

The rationale behind burst stimulation, noise stimulation, reconditioning stimulation and pleasure stimulation are embedded in a better understanding of brain homeostasis and allostasis. The talk will highlight how the future of brain, spine and nerve stimulation might dramatically change, by changing stimulation designs, rather than increasing accuracy.

Collaboration between bioelectronic engineers and neuromodulators (neurosurgeons, pain therapists,) is key to developing improved health care for neural disorders.


Dirk De Ridder, MD, PhD, is the Neurological Foundation professor of Neurosurgery at the Dunedin School of Medicine, University of Otago in New Zealand. His main interest is the understanding and treatment of phantom perceptions (sound, pain), especially by use of functional imaging navigated non-invasive (TMS, tDCS, tACS, tRNS, LORETA neurofeedback) and invasive (implants) neuromodulation techniques. He has developed burst and noise stimulation as novel stimulation designs for implants, and is working on other stimulation designs.

He has published 35 book chapters, co-edited the Textbook of Tinnitus, and has authored or co-authored more than 200 papers of which 180 PubMed listed papers. He is reviewer for more than 65 journals.


Section Bioelectronics

Wouter A. Serdijn

Sense of Contact

Sensing and Stimulating the Body with Electroceuticals

Wouter Serdijn

The 21st century will be the century of unravelling the intricacies of the brain and in which we will explore the use of electricy to interact with our electro-chemical mainframe better. In this talk I will explain how electroceuticals, the electronic counterparts of pharmaceuticals, can help to successfully treat neurological disorders. Further, I will sketch a technological avenue of their future development by making electroceuticals smaller, more energy efficient and more intelligent.

Additional information ...

Bioelectronics meeting

The monthly meeting of the Section Bioelectronics

Thanas Karapatis, Cees-Jeroen Bes, Sander Fondse

PhD Thesis Defence

Sensor management for surveillance and tracking. An operational perspective. March 5, 12.00 Aula, Senaatszaal. Promotor A. Yarovoy, co- promotor, H. Driessen

Fotios Katsilieris

Defence, March 5, 12.00 Aula, Senaatszaal. Sensor management for surveillance and tracking. An operational perspective. In the literature, several approaches to sensor (including radar) management can be found. These can be roughly grouped into: a) rule-based or heuristics; b) task-based; c) information-driven; and d) risk/threat-based. These approaches are compared in this dissertation and it is found that there is not a single approach that is both Bayes-optimal and takes into account explicitly the user requirements in different operational contexts. In order to overcome the challenges with the existing approaches, this dissertation proposes managing the uncertainty in higher-level quantities (as per the JDL model) that are directly of interest to an operator and directly related to the operational goal of a radar system. The proposed approach is motivated by the threat assessment process, which is an integral part of defence missions. Accordingly, a prominent example of a commonly used higher-level quantity is the threat-level of a target. The key advantage of the proposed approach is that it results in Bayes-optimal sensor control that also takes into account the operational context in a model-based manner. In other words: a) a radar operator can select the aspects of threat that are relevant to the operational context at hand; and b) external information about the arrival of targets and other scenario parameters can be included when defining the models used in the signal processing algorithms, leading to context-adaptive sensor management.

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Bioelectronics group meeting

The monthly group meeting of the Section Bioelectronics

Farnaz Nassiri Nia, Yao Liu

MEST event

TU Delft in ISSCC 2015


9:00 Prof. Kofi Makinwa Welcome
9:10 A. Carimatto A 67,392 SPAD PVTB-Compensated Multi-Channel Digital SiPMwith 432 column-Parallel 48ps 17b TDCs for Endoscopic Time-of-Flight PET
9:50 M. Shahmohammadi A 1/f Noise Up-conversion Reduction Technique Applied to Class-D and Class-F Oscillators
10:15 R. Quan A 4600um2 1.5oC (3s) 0.9kS/s Thermal-Diffusivity Temperature Sensor with VCO-Based Readout
10:40 Break
10:55 L. Xu A 110dB SNR ADC with +/-30V Input Common-Mode Range and 8uV offset for Current Sensing Applications
11:35 Y. He A 0.05-mm2 1-V Capacitance-to-Digital Converter Based on Period Modulation
12:00 H.Jiang A 30-ppm <80-nJ Ring-Down-Based Readout Circuit for Resonant Sensors

There will be free pizza from 12:45 to 13:15

MSc thesis presentation Jialue Wang

MSc thesis presentation Jialue Wang

Jialue Wang
TU Delft and the Holst Centre

Jialue Wang will present the results of his MSc thesis project at the Holst Centre on high-herformance DC-DC converters for RF energy harvesting nodes

Bioelectronics group meeting

Monthly meeting of the Bioelectronics group

On stage: Senad on a low-power ECG front-end, Andre and Wouter on BioCAS 2014 and Gustavo on optimizing the RF energy harvester and boost converter interface

Bioelectronics group meeting

Bioelectronics group meeting

Senad Hiseni, Yao Liu, Andre Mansano, Mark Stoopman

The monthly meeting of the Section Bioelectronics. This time on ExG frontend, ESSCIRC report, measurements of Mark's frequency synthesizer and PA.

MEST Colloquium

Electronics in Nano-Era: Are we Facing a Reliability Wall?

Said Hamdioui

The talk will address technology scaling and its impact on different aspects of IC and electronics, and in particular the emerging reliability bottlenecks. First the basics of scaling will be covered, together with its impact on integration density, performance and power. The technology outlook will be analyzed in order to extract the challenges with respect to design, test and reliability both for near and long terms. IC realization process will be (re) defined while considering the technology trends and business pressure. Possible ways for the realization of future systems will be discussed.

MSc thesis presentation Thanos Ramkaj

Analysis and Design of High-Speed Successive Approximation Register ADCs

Thanos Ramkaj

HIGH performance Analog-to-DigitalConverters (ADCs) are highly demanded by modern instrumentation, data acquisition and wire-line/wireless communication systems. However, the need for high speed is always accompanied by high power consumption and large area since amplifiers with large bandwidth and analog devices with low noise and high linearity are mandatory to fulfill the stringent requirements of high speed operation. Benefits of technology scaling and the flexibility of digital circuits raise the design challenges towards high gain, low noise and high linearity amplifiers, increasing the difficulty of implementing various ADC architectures with traditional analog techniques. New applications that constantly demand better performance in terms of speed and accuracy, have created a need for energy-efficient ADCs in the GHz sampling frequency and low-to-moderate effective resolution range. The dominantly digital nature of Successive Approximation Register (SAR) ADCs makes them a good candidate for an energy-efficient and scalable design, overcoming the aforementioned challenges, but its sequential operation limits its applicability in the GHz sampling range. It is of great interest to systematically study and understand the trade-offs in realizing such multi-GS/s, low power ADCs.

This thesis work analyzes the trade-offs in realizing SAR ADCs in the GHz range in terms of speed, accuracy, power and area. First, basic ADC principles such as quantization and sampling are discussed and performance metrics are introduced. Then, the theory is summarized and the advantages and disadvantages of various types of ADC architectures for high speed operation are pointed out, while analysis and evaluation of system and circuit level techniques, in order to overcome the speed limitation of SAR ADCs, and extend their operation in the GHz sampling frequency with affordable power and area trade-offs follow. Based on the aforementioned analysis, a novel architecture is proposed to break the speed limit due to sequential operation, and realize an 8-bit single channel 2 GS/s SAR ADC. The proposed architecture combines optimally the multibit/ cycle approach with interleaving comparators. Furthermore, other techniques such as separating the sample and DAC functions, a segmentation switching capacitive DAC with sub-fF unit capacitors and a very lowpower reference generator contribute in speed enhancement and power reduction. The effectiveness and performance of the proposed architecture and techniques is verified through both behavioral modeling (MATLAB, Verilog-A) and transistor level circuit simulations. The sub-blocks composing the ADC such as comparators, DACs, T/H, reference buffers, preamplifiers, biasing blocks, clock drivers are designed in 40 nm digital LP CMOS process and simulation results both for individual blocks as well as for the whole ADC are presented. Simulation results indicate a sample rate of 2 GS/s with an SNDR of 41.8 dB at Nyquist input frequency (1 GHz) and above 35 dB until 10 GHz input frequency, while consuming a total power of 17.2mWat 1.2 V supply.

MSc ME Thesis Presentation Menno Vastenholt

A Sub-GHz UWB Correlation Receiver for Wireless Biomedical Communication

Menno Vastenholt

MSc CE Thesis Presentation

Guaranteed Quality ECG Signal Compression Algorithm

Dongni Fan

The aim of the project is to develop an ECG signal compression algorithm that has a high compression ratio while guaranteeing signal quality.

An electrocardiography (ECG) signal is a representation of cardiac activity and has an need to be compressed to reduce data storage requirements. Previous ECG signal compression techniques have shown steady improvement on compression ratio. However, these techniques generally lack quality considerations, so their applications are limited. We present a discrete cosine transform (DCT) based compression scheme and use beat detection which considerably improve the compression ratio. The quality of the compressed signal is configurable, and the accuracy of the signal is maintained given a signal quality requirement.

The algorithm is implemented in a software/hardware solution. Some parts need to be done in the software. As a proof of concept, we have chosen the filter to be implemented in hardware. Mathworks HDL coder was used for generating RTL code and testbenches. Results show that our algorithm is capable of maintaining the specified quality, has a better compression ratio compared to previous work and is also capable to compress noisy ECG signals.

Additional information ...

MEST welcome drink

Meet and greet your friends and colleagues with a FREE Drink to say Hallo !!!

Organized by MEST student association

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Introductory Colloquium Arundhati Radhakrishnan

On techniques to remove blood clods from the rotor in a left ventricular assist device by means of ultrasound

Arundhati Radhakrishnan

Arundhati will present the first results from her experiments and further plans in the form of an Introductory Colloquium as part of her duties for her MSc final project in Biomedical Engineering.

Bioelectronics-ELCA daytrip

Bioelectronics-ELCA daytrip

Marion de Vlieger

By bus to Haarlem, guided tour through the city, visiting Teylers Museum incl. lunch, boat tour on the Spaarne, by bus to Zandvoort for the BBQ.

Additional information ...

CMOS-based implantable electronics for bioscientific and medical applications

Takashi Tokuda
NAIST, Japan

CMOS-based implantable device technology is attracting a lot of interest because of its potential for next-generation bioscientific and medical applications. In this presentation, circuit design, device packaging, and functional demonstration of some CMOS-based implantable devices are presented. An implantable imaging device for in vivo (in a living body) optical brain imaging, implementation of light source for neural stimulation in optogenetics, and flexible neural stimulator for retinal prosthesis will be mainly described.

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Bioelectronics Section meeting

Monthly meeting of the Section Bioelectronics

The RF Task Force (Yao, Mark, Andre, Gustavo), Gustavo, Jialue

Bioelectronics Section Meeting

The monthly meeting of the Section Bioelectronics

Yao Liu, Andre Mansano

Electroceuticals Webinar

Electroceuticals Webinar

Bioelectronics webseminar meeting, Monday, July 7, 14:00 hrs

Dear all,

GlaxoSmithKline (the inventors of the word "Electroceutical"),, has launched an initiative to make groups around the world collaborate on their mission, the development of Bioelectronic Medicine.

Which is what we do, from an electronics perspective.

In order to facilitate this collaboration, they have created a special web portal for collaboration that also includes videos on recent developments in the various disciplines, the Innovation Challenge Portal:

Two web seminars can be found on this web portal that I would like to watch together with you (+ everybody else that is interested), on:

Monday, July 7, at 14:00 hrs, in the Davidse Room (EWI 18.230).

Webinar 1: Disruptive neural interface technologies

Moderator, Jack Judy, PhD

In this webinar moderated by Jack Judy of University of Florida, presenters explain how non-traditional approaches developed for the CNS could be adapted to interface with peripheral nervous system. Techniques include magnetic ultrasound, nanomolecular technologies, neural dust and non genetic optical reporters (e.g: Nanodiamonds). And, if time permits, Webinar 2: High-density peripheral recording and stimulation Moderator, Moderator, Dustin Tyler (CWRU) How can we scale to high density neuronal recording and stimulation? How can we best achieve signal analysis and modelling in the peripheral nervous system? In this webinar moderated by Dustin Tyler (Case Western Reserve University) we learn more about the challenges of high-resolution nerve interfaces. You are all welcome to attend. Wouter

Invited talk in Lausane

Wireless Active Implantable Medical Devices

Wouter Serdijn
Delft University of Technology

Additional information ...

Bioelectronics Section meeting

Reza Lotfi, Marijn van Dongen, Walter Hamelink

The monthly meeting of the Bioelectronics group

ISCAS 2014

2014 IEEE International Symposium on Circuits and Systems

Welcome from the General Chairs of the Organising Committee

On behalf of the Organising Committee we welcome you to Melbourne, ranked by the Economist Intelligence Unit in 2011, 2012 and 2013 as the most liveable City in the world, to Australia, and to the 2014 IEEE International Symposium on Circuits and Systems.

ISCAS2014 is sponsored by the Institute of Electrical and Electronic Engineers Circuits and Systems Society (IEEE CASS), and generously supported by the State Government of Victoria and the Melbourne Convention Bureau.

As you all know, ISCAS is the flagship annual conference of IEEE CASS, and it is well established as the worlds premier networking forum in the fields of theory, design and implementation of circuits and systems. As a result of the release of its 2012 Vision and Mission (see, the CASS goal is to develop ISCAS also as the leading forum for pioneering circuits and systems contributions to humanitys grand challenges.

Accordingly, the special theme of ISCAS 2014 is nano/bio circuits and systems applied to enhancing living and lifestyles, particularly in relation to the multidisciplinary grand challenges in healthcare and wellbeing, the environment and climate change.


ISCAS2014 has four keynote presentations, two of which address crucial aspects of high priority grand challenges, in health and in sustainability, while the other two describe frontier work at the extreme ends, in terms of scale, of circuits and systems engineering new devices that promise to sustain the remarkable advances in semiconductors that we have enjoyed for over 60 years, and design methods for systems of systems, which are relevant to so many grand challenge problems:

Dr Donald E. Ingber from Harvard University on Monday will present Microengineered Human Organs On Chips, describing advances he and his team have made in the engineering of microfluidic Organs-on-Chipsmicrochips lined by living human cells created with microfabrication techniques that recapitulate organ-level structure and functions as a way to replace animal testing for drug development and mechanistic discovery.

Professor Iven Mareels from The University of Melbourne in his talk on Wednesday, titled Circuits and Systems for Modern Irrigation Management, describes work over 15 years on circuits and systems research, development and commercialisation of an internet-of-things dedicated to smart irrigation water management.

Professor Victor Zhirnov from the Semiconductor Research Corporation, in Scaling Limits of Nanoionic Devices, elaborates how recognition that crystal defects could be used as controllable entities, rather than being seen as imperfections, leads to the possibility that nanoionic resistive switching devices may be scalable down to ~ 1nm and thus may offer a promising path to replace the foundation of todays computing technologies.

Dr. Stephan C. Stilkerich from Airbus Group will present Model Based Engineering of Highly Mobile Systems of Systems: Safe Aeroplanes; Safer Automobiles, with an introduction and post-talk discussion moderated by Dr Graham Hellestrand from Embedded Systems Technology. This keynote deals with front-line approaches to engineering electronic systems and their software, that are required to perform real-time control critical for the safe operation of airplanes and cars, including while operating in dense traffic and simultaneously reducing environmental impact.

Technical Program Regular Sessions

The technical program consists of tutorials, lecture papers, poster papers and demonstrations accepted based on peer review of the submission from regular open calls. We have retained many of the ISCAS features that have evolved in recent years, and added new features, some in response to ISCAS feedback, to continue to improve attendees experience of the event.

We are very pleased to report that ISCAS2014 will be first time that the new CASS Conference App will be made available to all attendees, and we look forward to your feedback to improve it. The CAS Society has supported the development of the Conference App, through Conference4Me, to facilitate the navigation of the conference agenda and venues, secure access to proceedings, micro-blogging, live discussion and ranking of papers, providing feedback to organizers and general improvement of attendees experience at CAS conferences.

Lecture papers follow the traditional ISCAS format. There are nine lecture sessions over three days, with session having 11 parallel streams. Sessions are 90 minutes with up to five papers, allowing 18 minute for each including introduction, presentation and discussion.

The Demonstration session and Poster sessions are held over 3 hours commencing at the 3pm coffee break on Monday, Tuesday and Wednesday. The Demonstration session is Monday only. There are no competing parallel lecture sessions during the first 90 minutes of each days Posters/Demonstrations, allowing increased attention to them from all attendees.

We have increased the length of the lunch break to 90 minutes. This will allow more time for the CASS side meetings, particularly the annual meetings of the 15 CASS Technical Committees, which are playing an increasingly important role in leadership of the Society. The longer break will also provide a more relaxed walk to the nearby restaurants for the lunch break, and we hope it will facilitate a greater level of networking.

Following the ISCAS2013 lead we continue the trial of offering free attendance at Tutorial and CAS-FEST sessions for all ISCAS2014 registrants. We have also expanded both the tutorial program and CAS-FEST. CASS goals in these moves are both to widen the reach of and to increase participation in the tutorial program and CAS-FEST. We will greatly appreciate feedback from attendees on the value you perceive in these offerings.


ISCAS2014 commences on Sunday with 19 half-day and 1 full-day Tutorial sessions.

We have included two Tutorial sessions on Technology Management in response to feedback from CASS industry members:

T19 Interfacing Organisations: How to successfully manage organizational interfaces by Felix Lustenberger; and T20 - Managing Technology Professionals by Tuna B. Tarim: Transitioning from Individual Contributor to Management. Felix and Tuna are CASS members and also leaders of IEEEs Technology Management Council, which was recently approved to transition to an IEEE Society.

Also in response to feedback, from the Women in CAS (WiCAS) and Young Professionals Program (formerly GoLD) groups, is a tutorial on career development, social skills, collaboration and networking:

T7 Engineering Networks that Work: Design Tools for Your Career by Dr Margaret Collins Margaret is a Cardiff-based research consultant, professional coach and trainer with extensive experience in helping people achieve their career goals. Come ready to get involved this is an active workshop session!

A third initiative in the Tutorials is a full day introduction to Memristive devices, circuits, systems and applications, the topic of this years CAS-FEST. This will cover all aspects of this emerging technology, namely: theory, practical nanodevices, physical switching mechanisms, circuits and emerging applications:

T21 If its Pinched its a memristor (AM), Professor Leon Chua T22 ReRAM Memristive Devices: Electrochemical Systems at the Atomic Scale (AM), Dr Ilia Valov T23 Analog and Mixed-Signal Applications of Memristive Devices (PM), Professor Dmitri Strukov T24 Integrating memristive devices in CMOS neuromorphic computing architectures (PM), Professor Giacomo Indiveri The aim of these sessions is to provide sufficient introduction to enable a typical ISCAS attendee to appreciate the state of the art material that will be presented in the CAS-FEST sessions.


Since its inception in 2010, the Circuits and Systems Forum on Emerging and Selected Topics has progressively become more closely integrated with ISCAS. This years topic was again selected from an open call and the winning proposal, from members of the Nonlinear Circuits and Systems (NCAS) Technical Committee, has taken still further this level of integration with ISCAS. This includes the presentation of invited introductory tutorials in the regular ISCAS Tutorials program (see above), the inclusion of three Special Sessions in the regular ISCAS Lecture Papers program, a full day of CAS-FEST Special Sessions on Wednesday, and the highlight full day of CAS-FEST Keynote talks on Thursday.

With this additional integration, CAS-FEST 2014 will bring together leading experts and provide a thorough coverage of the field of memristors, from an introduction to those unfamiliar with the field, through solidifying existing knowledge, to highlighting developments at the forefront of the field, and pointing to future challenges and promising directions for research. We hope that this coordinated approach will result in a landmark event in the development of the field.

Social Events and Awards Dinner

We are planning the now standard set of ISCAS evening events, with the Welcome Reception on Sunday evening soon after the conclusion of Tutorials, the WiCAS/YPP (formerly GoLD) event on early Monday evening, the Awards Dinner on Tuesday evening, and the Closing Reception immediately following the last session on Wednesday. Watch out for the Australian twists!

We hope that you will have a rewarding and enjoyable time in Melbourne at ISCAS2014 and look forward to meeting as many of you as we can!

Professor Jugdutt (Jack) Singh & Dr David Skellern General Co-Chairs, ISCAS 2014

Additional information ...

Invited talk Wouter A. Serdijn

Circuits and Systems for Electroceuticals

Wouter Serdijn

Title: Circuits and Systems for Electroceuticals Abstract: In the design process of electroceuticals, such as hearing instruments, pacemakers, cochlear implants and neurostimulators, the tradeoff between performance and power consumption is a delicate balancing act. In this presentation I will cover techniques to deal with the acquisition and generation of electrophysiological signals and to provide reliable communication with and through the body. We will discuss signal-specific analog-to-digital converters, morphological filters, arbitrary-waveform neurostimulators, energy harvesting and ultra wideband wireless communication from a low-power circuits and system perspective. Design examples and their performance will be discussed and an avenue sketched for treatment of various neurological disorders, such as tinnitus and addiction.

Additional information ...

IEEE Distinguished Lecturer talk Wouter A. Serdijn

Circuits and Systems for Electroceuticals

Wouter Serdijn
Delft University of Technology

In the design process of electroceuticals, such as hearing instruments, pacemakers, cochlear implants and neurostimulators, the tradeoff between performance and power consumption is a delicate balancing act. In this presentation I will cover techniques to deal with the acquisition and generation of electrophysiological signals and to provide reliable communication with and through the body.

We will discuss signal-specific analog-to-digital converters, morphological filters, arbitrary-waveform neurostimulators, energy harvesting and ultra wideband wireless communication from a low-power circuits and system perspective. Design examples and their performance will be discussed and an avenue sketched for treatment of various neurological disorders, such as tinnitus and addiction.

Additional information ...

Lecture on wearable and implantable medical devices

Lecture on wearable and implantable medical devices

Wouter Serdijn

Wouter Serdijn will present a lecture on wearable and implantable medical device electronics

Additional information ...

BME Literature Review

Left Ventricular Assist Devices: how to prevent thrombae

Arundhati Radhakrishnan
Delft University of Technology and Erasmus Medical Center

Arundhati Radhakrishnan will present her literature review as part of the requirements for the MSc Biomedical Engineering studies

Lecture on ExG signal acquisition and processing electronics

Lecture on ExG signal acquisition and processing electronics

Wouter Serdijn

Wouter Serdijn will present the BELEM lecture on ExG signal acquisition and processing electronics

Additional information ...