Bioelectronics
Department of Microelectronics

Ronaldo Martins da Ponte

Publications

  1. Bidirectional Bioelectronic Interfaces: System Design and Circuit Implications
    Y. Liu; A. Urso; Martins da Ponte, Ronaldo; T. Costa; V. Valente; V. Giagka; W.A. Serdijn; T.G. Constandinou; T. Denison;
    IEEE Solid-State Circuits Magazine,
    Volume 12, Issue 2, pp. 30-46, 23 June 2020. DOI: 10.1109/MSSC.2020.2987506
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  2. Monolithic Integration of a Smart Temperature Sensor on a Modular Silicon-based Organ-on-a-Chip Device
    Martins da Ponte, Ronaldo; Nikolas Gaio; Henk van Zeijl; Sten Vollebregt; Paul Dijkstra; Ronald Dekker; Wouter A. Serdijn; Vasiliki Giagka;
    Sensors and Actuators A: Physical,
    Nov. 21 2020. ISSN 0924-4247.
    Keywords: ... Organs-on-a-chip; Smart temperature sensor; Time-mode domain signal processing; MEMS; CMOS Monolithic Integration; MEMS-Electronics co-fabrication.

    Abstract: ... One of the many applications of organ-on-a-chip (OOC) technology is the study of biological processes in human induced pluripotent stem cells (iPSCs) during pharmacological drug screening. It is of paramount importance to construct OOCs equipped with highly compact in situ sensors that can accurately monitor, in real time, the extracellular fluid environment and anticipate any vital physiological changes of the culture. In this paper, we report the co-fabrication of a CMOS smart sensor on the same substrate as our silicon-based OOC for real-time in situ temperature measurement of the cell culture. The proposed CMOS circuit is developed to provide the first monolithically integrated in situ smart temperature-sensing system on a micromachined silicon-based OOC device. Measurement results on wafer reveal a resolution of less than ±0.2 °C and a nonlinearity error of less than 0.05% across a temperature range from 30 °C to 40 °C. The sensor's time response is more than 10 times faster than the time constant of the convection-cooling mechanism found for a medium containing 0.4 ml of PBS solution. All in all, this work is the first step towards realising OOCs with seamless integrated CMOS-based sensors capable to measure, in real time, multiple physical quantities found in cell culture experiments. It is expected that the use of commercial foundry CMOS processes may enable OOCs with very large scale of multi-sensing integration and actuation in a closed-loop system manner.

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  3. CO-INTEGRATION OF FLIP-TIP PATCH CLAMP AND MICROELECTRODE ARRAYS FOR IN-VITRO RECORDING OF ELECTRICAL ACVITY OF HEART CELLS
    Asli Yelkenci; Martins da Ponte, Ronaldo; Virgilio Valente;
    In Book of Abstracts, 7th Dutch Biomedical Engineering Conf. (BME) 2019,
    Jan. 24-25 2019.
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  4. DESIGN AND CUSTOM FABRICATION OF A SMART TEMPERATURE SENSOR FOR AN ORGAN-ON-A-CHIP PLATFORM
    Martins da Ponte, Ronaldo; Vasiliki Giagka; Wouter A. Serdijn;
    In Book of Abstracts, 7th Dutch Biomedical Engineering Conf. (BME) 2019,
    Jan. 24-25 2019.
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  5. DESIGN OF A MULTI-FUNCTIONAL SMART OPTRODE FOR ELECTROPHYSIOLOGY AND OPTOGENETICS
    Martins da Ponte, Ronaldo; Chengyu Huang; Vasiliki Giagka; Wouter A. Serdijn;
    In Book of Abstracts, 7th Dutch Biomedical Engineering Conf. (BME) 2019,
    Jan. 24-25 2019.
    document

  6. Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform
    Martins da Ponte, Ronaldo; Vasiliki Giagka; Wouter A. Serdijn;
    In proc. IEEE Biomedical Circuits and Systems Conference (BioCAS 2018),
    IEEE, Oct. 17-19 2018.
    document

  7. MEMS-Electronics Integration: A Smart Temperature Sensor for an Organ-on-a-chip Platform
    Martins da Ponte, Ronaldo; Vasiliki Giagka; Wouter A. Serdijn;
    In Proc. ProRISC,
    Enschede, the Netherlands, June 7-8 2018.
    document

  8. Towards a Flexible Implant with Distributed Electronics, Wireless Communication and Energy Transfer
    Martins da Ponte, Ronaldo; Vasiliki Giagka; Wouter Serdijn;
    In Book of Abstracts, 6th Dutch Bio-Medical Engineering Conference, 26 and 27 January 2017, Egmond aan Zee, The Netherlands,
    2017.
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  9. MEMS-electronics integration: a smart temperature sensor for an organ-on-a-chip platform
    Martins da Ponte, Ronaldo; V. Giagka; W.A. Serdijn;
    In Proc. Design of Medical Devices Conf. (DMD) 2017 Microfabrication for Medical Devices,
    Eindhoven, 14 – 15 Nov 2017.
    document

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