MSc thesis project proposals

Here is a list of possible MSc thesis projects. This is intended just to give an idea, actual projects are usually defined after discussion with the advisor.

[2021] Data Acquisition System for High-throughput Electrophysiological Signals Recording with Microelectrode Array Chip

Biosignal acquisition, conditioning and processing

[2022] Smart Vital Signs Monitoring in Wearables [in collaboration with NXP]

Design low-power and compact embedded signal processing and machine learning algorithms for autonomous vital monitoring in wearables.

[2020] BabyPleister: Health condition monitoring of newborns at home. [Already taken]

The goal of this project is to improve maternity care at home with a sensor patch.

Analysis of 3D right ventricular shape from echocardiography

The functioning of our hearts is of vital importance to physical wellbeing. The right half of the heart is responsible for collecting the returning blood from the main circulation and pumping it to the lungs, where it is resupplied with oxygen. When the functioning of the right ventricle is compromised, venous pressure will rise and lung function will be decreased, leading to severe health problems on the long term.

Volumetric photoacoustic imaging of kidney

Photoacoustics (PA) is a rapidly developing imaging modality which provides information about the molecular composition of biological tissue. The photoacoustic signal is generated by so-called chromophores, such as biological molecules that absorb light, which can transform absorbed light into an ultrasound signal. The presence of certain types of chromophores can be a valuable marker indicating the condition of biological tissue. The accurate quantification of certain types of chromophores can improve clinical diagnosis. However, at each moment, only a limited area of human tissue can be exposed by a light (laser) which impedes volumetric analysis of present chromophores. The goal of this project is to quantify present chromophores in large organs, e. g. kidney, which are normally challenging to be fully imaged with PA.

Microsystem integration

Conditioning Navier-Stokes based velocity field regularization with sparse high-fidelity data

Vector flow imaging (VFI), a relatively recent development in diagnostic ultrasound research, describes a group of flow imaging methods that quantify both the magnitude and angle of the blood velocity vectors in the organ of interest (e.g. the heart). This is in contrast to traditional Doppler ultrasound which only estimates the velocity component on the axis towards the transducer.

[2021] In-ear Heart Rate detection in a custom-fit headset. [with DOPPLE] [Already taken]

An efficient heartbeat sensor for in-ear headsets is very useful for in fitness and health applications.

Transcutaneous Wireless Communication

[2021] Body Coupled Communication for Microscale Implants

This project aims to investigate the applicability of body-coupled communication (BCC) for a network of micro-scale implants. The project's main goal is proposing and implementing a lightweight network protocol suitable for implantable micro-scale devices and/or implementation of an energy-efficient tissue interface for the BCC method.

[2020] Body-coupled communication to enhance IMD security

MSc thesis project in collaboration with the implant security experts of ErasmusMC (Dept. Neuroscience) on their holy mission to make active medical implants safe, secure and dependable.

Wireless Power Transfer, Power Management and Energy Harvesting

[2022] External electronics for ultrasonically powered stimulators

The main objectives of this project are proposing, implementation and test of a link management strategy for the application of ultrasonically powered stimulator(s).

Transcutaneous Wireless Communication

[2021] Network of individually addressable ultrasonically powered implants

MSc thesis project in microelectronics on designing (on chip) light-weight and chip-scale communication protocols and addressing strategies for a network of ultrasonically powered implants

Wireless Power Transfer, Power Management and Energy Harvesting

Various projects on energy harvesting and power management in collaboration with NOWI

NOWI is a semiconductor company that developed the world’s most innovative energy harvesting IC with the smallest assembly footprint. Our Bioelectronics group has a long-standing relationship with NOWI and has contributed to several of its products. For the coming academic year, NOWI offers 5 MSc thesis projects. Click below for more information.

Flexible implants

[2022] Smart transparent electrode array for electroceuticals

In this project, we wish to take electroceuticals to the next level, by fabricating new, compact, flexible and transparent active neural interfaces.

[2022] Ultra-Flexible Active-Matrix Electrophysiology Arrays for Neural Interfacing

MSc thesis opportunity for an EE or BME student at the Holst Centre in Eindhoven on the development and characterization of active-matrix TFT arrays on foil with three-dimensional conformability for improved neural interfacing.

Microsystem integration

[2022] Active neural interfaces for Bioelectronic Medicine (MSc project at Fraunhofer)

Project outside the university in collaboration with Fraunhofer Institute for Reliability and Microintegration in Berlin, Germany

Neuroprosthetics, - stimulation and -modulation

[2022] Lossless integration of 2D arrays of piezoelectric transducers in CMOS technology (Taken)

This projects targets the design, fabrication and experimental validation of lossless methods for integrating piezoelectric transducers with silicon substrates, for the next generation of miniaturized ultrasound neuromodulation devices.

[2022] Acoustic holograms for precise generation of focused ultrasound waves

The objective of this project is to explore the manufacturing of acoustic holograms using micro and nanofabrication techniques, towards high-spatial resolution ultrasound stimulation of neurons.

[2022] A wearable ultrasonic vagus nerve stimulator

Bioinspired electronics

[2022] Self Powered Neuromorphic Pressure Sensor Readout System for Robotics

Design a spiking neuron circuit that simultaneously reads the pressure applied to a piezoelectric sensor and harvests energy from the sensor itself to operate.

[2022] Stochastic-resonance front-end for the acquisition of high-density cortical signals

This is a scientific technology project that is unique in its kind and therefore extremely well suited for MSc students that might be interested in doing a PhD project directly after their MSc studies.

Sensors and Actuators

[2021] Electronic anal sphincter device as a surgical treatment option for incontinence

Fecal incontinence is the inability to control bowel movements causing stool to leak out. Fecal incontinence is very common but because of the associated embarrassment and taboo nature, it is under-reported and its true prevalence difficult to reliably assess. If treatment is sought, there is no universal treatment and patients can be left with poor sphincter control or a lack of independence

Microsensors

A biodegradable hernia post-operative monitoring implant

The aim is to develop methods to make biodegradable sensors for implants

Hernia post-operative monitoring

Incisional hernia (IH) is a complication which can occur after surgery to the abdomen. In order to prevent IH, a mesh can be used. This holds the tissue in place to reinforce it and to enable healing. However, in some cases the healing does not take place correctly and IH is not prevented. In order to monitor healing, scans or ultrasonography can be used, but these diagnostic tools are expensive and time consuming. The aim of this project is to create a “bionic” mesh which can detect the early stages of IH formation with a device attached to the tissue around the wound.

Microsystem integration

[2020] A system for blood analysis of newborns using Microneedles (with Stellenbosch South Africa)

This project aims to develop a novel, minimally invasive, detection method for jaundice (geelzucht).

[2022] Electro-acoustic heart interface for mapping 3D cardiac electro-mechanical coupling in Arrhythmia

Sensors and Actuators

Photoacoustic techniques for plaque detection

Atherosclerosis is a progressive inflammatory disease that is characterized by the accumulation of lipids in the artery wall. The composition withholds information about the risk of it causing a cardiovascular event. Currently used imaging techniques in carotid atherosclerosis provide mostly morphological information and lack molecular information.

Microsensors

[2020] Ammonia & humidity sensors

Development of a ammonia/humidity sensor for harsh environments.

[2020] Heartbeat measurement by infrared detection in the ear

Non-contact (infrared) temperature measurement in the ear canal is an attractive yet challenging method for heartbeat detection.

Microsystem integration

Self-test for IR Sensors

In many applications, the lens and packaging of IR sensors can become contaminated leading to measurement error and apparent failure. A self-test built into the package could solve this problem. This project concerns the development of a self-test system which can compensate for minor contamination and produce a warning for higher contamination levels.

The effect of fast microbubble motion on contrast pulse sequences

Ultrasound contrast agent (UCA), most commonly in the form of 1-10 µm microbubbles consisting of a lipid-monolayer shell with an inert gas core, are used to opacify the blood pool in ultrasound imaging. A more recent application of UCA is as tracer agents for echo-particle image velocimetry (echoPIV) where high frame-rate ultrasound imaging is used to track the motion of the microbubbles as they flow with the blood.

Medical applications for custom-fit wireless headsets

New wireless headsets, that combine audio applications (music/voice calls) with sensor applications are entering the market. Integration with new sensors in custom-fit headsets provides new opportunities in medical, fitness and home care applications.

Sensors and Actuators

A biodegradable device for measuring tissue vitality in internal wounds healing

The aim is to develop biodegradable sensors for tissue viability measurement.

Detection of prostate cancer in urine

Prostate cancer is a major problem for men over the age of 55. Early diagnostic is extremely important. Present techniques are expensive and/or cause great discomfort. This project, in collaboration with The Hague University of Applied Science and Erasmus Medical Centre, aims to address these issues.

Achilles tendon injury and recovery

When the Achilles tendon is overloaded, it is painful and needs to recover. This process is not well understood. This project is directed towards a better understanding of the role of dynamic loading in overloading and recovery of tendon.

Embryo development

This project involves a study of the development of an embryo and the effect of mechanical stress.

Lab-on-a-chip

[2020] Electronic lateral flow immunoassay

Sensors and Actuators

[2020] Unobtrusive monitoring of internal bleeding

Internal bleeding is a major cause of death. This project aims to develop an unobtrusive method for monitoring internal bleeding.

Modelling for fontain circulation in congential heart disease

Children born with a single-ventricle heart defect need a series of operations, otherwise they will die in the first week of their life. Since the dysfunctional ventricle cannot be repaired, surgeons connect the functional ventricle to the aorta and the venous blood flow is redirected such that it passively returns to the lungs, thereby bypassing the heart. The final result is a so called Fontan circulation (Figure left panel). Patients with a Fontan circulation often suffer from limited exercise capacity, which is thought to be related to the geometry of and the altered hemodynamics in the Fontan circulation. Moreover, these patients use medication their entire life to avoid blood clotting.

[2020] Active Acoustic Channel for Dynamic Hearing Protection

Brain-Machine Interfaces

[2022] Low Power Analog Front-End Resilient to Large Electrode Impedance for ExG Applications

IC design for a neural readout for ExG applications

Bioelectronics

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