News

Dante Muratore gave an interview in La Republica

Dante Muratore gave an interview in La Republica about his research and experience at the TU Delft.
Dante Muratore: I said no to Elon Musk to create a chip that will help those who have lost their sight "to see the stars again" - la Repubblica

News archive

Portrait of Medical Delta Professor Johan Frijns (appointed at EEMCS, Bioelectronics group)

Portrait of Medical Delta Professor Johan Frijns 

More than 800,000 people in the Netherlands are hard of hearing. They suffer so much from hearing loss that it limits their daily lives. Prof. Dr. ir. Johan Frijns treats people with hearing loss, conducts research on hearing implants, and gladly shares his knowledge about electrical stimulation of the nervous system. "We shouldn't want to reinvent everything in every little corner. What we learn in one place, we can also use in another."

Johan Frijns is a professor of Otology and Physics of Hearing in the Department of Otorhinolaryngology at LUMC. He heads the Center for Audiology and Hearing Implants Leiden (CAHIL) and the Cochlear Implant Rehabilitation Centre Leiden (CIRCLE). He was recently appointed as a Medical Delta professor with a position at the Faculty of Electrical Engineering, Mathematics, and Computer Science at TU Delft.

Read more: Portrait and video Johan Frijns: “When a deaf child suddenly hears and learns to talk, this also has a huge impact on the people around him.” | Medical Delta

 


Artikel AD tinnitus

Onze hersencellen werken als elektronische netwerken en daar kan ik veel mee”, aldus professor Wouter Serdijn van de Sectie Bio-elektronica van de TU Delft. Serdijn zoekt naar een oplossing voor tinnitus. © Thierry Schut

Source (paywall): https://www.ad.nl/binnenland/elektrotechnisch-ingenieur-en-neurochirurg-denken-oplossing-voor-tinnitus-gevonden-te-hebben~abb033f4/

Read the full story here: Tinnitus.

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Andrew Webb wins Huibregtsen Award for Affordable MRI Scanners

High field MRI expert, Professor Andrew Webb of the Microelectronics department, and his Ugandan collaborator, Johnes Obungoloch, have been awarded the 2023 Huibregtsen Prize. Their notable achievement is the creation of an affordable, portable, and long-lasting MRI device tailored for brain imaging in developing nations.

Webb's team introduced a 'low-field MRI scanner' that boasts ease of transportation, maintenance, and ecological sustainability. Ever better, Webb’s new device is priced at just 1% of the typical MRI system. The brain scans generated by their MRI are instrumental in diagnosing curable diseases in underdeveloped regions, with the first model already operational in Uganda.

Highlighting its distinctive nature, the jury commended the initiative for merging top-tier technology development with suitability for developing regions. They also lauded the emphasis on knowledge dissemination and instruction.

The Huibregtsen Prize, founded in 2005 by The Evening of Science & Society Foundation board, is an annual award recognizing pioneering research projects with profound societal implications.
The accolade was handed over by the departing Minister of Education, Culture, and Science, Robbert Dijkgraaf, on 9 October at Pieterskerk, Leiden. Professor Webb was granted a €25,000 check and a bronze artwork from Wil van der Laan. Meanwhile, Obungoloch tuned into the event via a live stream from Uganda. In addition to the monetary prize and artwork, the duo also earned a workshop at the Lorentz Center in Leiden.

 


Gaat dit apparaatje tinnitus genezen?

Een constante piep of ruis in je oren - om gek van te worden. Toch is er geen genezing voor mensen met tinnitus. Nog niet, want elektrotechnisch ingenieur Wouter Serdijn (TU Delft) laat het er niet bij zitten. Hij werkt aan een apparaatje dat tinnitus moet verhelpen. Hoe? Dat hoor je in deze aflevering van de podcast van de Universiteit van Nederland.

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Vacancy for a Bioelectronics Support Engineer

Join our dynamic team at Delft University of Technology's Section Bioelectronics in the Department of Microelectronics! As a Bioelectronics Support Engineer, you will play a pivotal role in enabling groundbreaking neuroscientific research and the development of cutting-edge neurotechnology applications.

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Our Paper Awarded at the IEEE MetroAeroSpace 2023

We are proud to announce that our paper, "Experimental Evaluation of Radar Waveforms for Spectral Coexistence Using the PARSAX Radar", the result of our research collaboration with the team from the University of Naples “Federico II”, has been recognized as the most outstanding paper of the Special Session on Metrology for Radar Systems presented at IEEE MetroAeroSpace 2023 (the award has been sponsored by MDPI Remote Sensing Journal). The paper was acknowledged for its experimental demonstration of radar operability in spectrally dense environments through innovative waveform design.

The award recognition will soon be posted on the official conference website.


SAFE/ProRISC conference 2023 in Delft

On 10-11 July 2023 we have the SAFE/ProRISC conference in Delft. This is an annual conference rotating around the TU's in The Netherlands.

SAFE is dedicated to devices and technology, and ProRISC to circuits and systems. You can find more information on the website:

https://www.tudelft.nl/prorisc-safe

For PhD students, this is a great opportunity to meet colleagues from the other TU's, and also have fun. We only require an abstract and poster, so there is no problem with prior publication if you want to present the work at an international conference.


Graphene electrodes developed by ME researchers on Neurotech reports

The article "Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfaces", published in Microsystems & Nanoengineering (Nature), is featured in the February 2023 issue of Neurotech Reports. 

The electrodes in the study were fabricated at the Else Kooi Lab and are the product of a longstanding collaboration between the groups of Sten Vollebregt and Vasso Giagka. The article was selected to be featured on the journal's webpage in October 2022.

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Webinar with Dr. Vasso Giagka "Translational Research for Neural Implants"

This webinar will be hosted live and available on-demand

Monday, May 8, 2023, at 17:00

Implantable neurotechnologies already treat various disorders, including epilepsy, Parkinson’s disease, depression, and pain. As researchers develop new materials and technologies, the therapeutic potential of neural implants for other diseases and conditions grows. 

In this webinar brought to you by The Scientist, John Donoghue and Vasiliki (Vasso) Giagka will present their latest findings on applying clinical and technical developments to create new implantable devices for treating neurological disorders. 

Topics to be covered 

  • Successes, challenges, and opportunities for brain computer interfaces (BCIs)
    • Accomplishments in human implantable BCIs over the last decades
    • Current capabilities for movement and communication
    • Challenges for clinically useful BCIs as medical devices
  • Miniaturized and selective active neural interfaces
    • Active neural implants for bioelectronic medicine
    • Miniaturization of active neural implants
    • Multimodal neural interfaces

Register through the link

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Squeaking, humming, buzzing. The discomfort of tinnitus

A few years ago, the Bioelectronics group (Faculty of Electrical Engineering, Mathematics and Computer Science) joined an international project on tinnitus called Tinnitus House. Delta phoned TU Delft principal investigator Professor Wouter Serdijn to hear about the progress.

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2022 4TU.NIRICT Community Day, November 14

Identified are 3 themes around which we would like to bring NIRICT researchers together to discuss and to explore per theme the opportunities for interdisciplinary collaboration. The themes are related to the societal challenges we are currently facing and require interdisciplinary effort in order to be addressed effectively. We believe that productive discussions during the event could be instrumental in forming new research lines, but also project consortia around various national R&D investment programs addressing the knowledge and innovation agenda’s (KIAs) of the Netherlands (https://www.topsectoren.nl/missiesvoordetoekomst).


Themes of the day:
• Health and ICT People live longer, more healthcare is needed. Work pressure in healthcare is rapidly increasing. More data is collected by smart devices. How can the ICT community contribute solutions to keep our society healthy?
• Energy and ICT The current explosion of the energy prices shows that we are facing an unstable situation with respect to energy production and consumption. We produce more solar energy on one hand and consume more energy due to air conditioners and electric cars. We need smart solutions both in production and consumption. Moreover, due to its significant share in energy consumption, ICT systems from the end user devices to power-hungry data centers need to become more energy efficient.
• Agriculture and ICT We just had another summer with extreme heat waves and droughts. The climate changes we are facing have tremendous consequences for agriculture. The population is growing and the pressure on nature is increasing. What smart solutions do we see to deal with the challenges to keep our planet healthy and at the same time to keep the food production in line with the population growth?
The Community Day starts at 12:30hrs with a walk-in lunch. At 13:30hrs the official part will start with a number of short presentations, followed by several parallel sessions regarding the three themes of the day. You can indicate your preference on the registration form. Afterwards there will be a networking drink from 17:00-18:00hrs.

It would be great to welcome many of you on November 14th, because together we strengthen the ICT community of The Netherlands, so join us for the 4TU.NIRICT Community Day 2022, November 14, in Van der Valk Hotel Utrecht and register here by November 6, 2022.
Your data will only be used for registration and will be discarded within one week after the 4TU.NIRICT Community Day. If you have any questions, don’t hesitate to contact us: m.mommers@tue.nl


Sounds good: treating depression with ultrasound

Physicians are desperate to find new and effective treatment options for chronic pain and depression. Tiago Costa is developing a novel targeted neuro-modulation treatment for depression, using focused ultrasound. His goal is to treat only brain areas that need attention, leaving other parts of the brain undisturbed.

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Vasso Giagka on the Neural Implant Podcast

Neural Implant podcast - the people behind Brain-Machine Interface revolutions: Vasiliki Giagka on Neural Interface Packaging and why it's the most important

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Technology for health: Keynote Wouter Serdijn en Christos Strydis at the Opening of the Academic Year

In Delft and Rotterdam, Wouter Serdijn and Christos Strydis are collaborating on a network of sensors and stimulators for the body. By picking up signals and sending the brain a rapid wake-up call, they hope to be able to predict and prevent epileptic seizures.

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Gravity grant awarded to research on brain interactions

The goal of this research is to develop principles, devices and methods to take these interactions into account and thus understand more about brain disorders, as well as moods, emotions and compulsions.

The research project is called 'The Dutch Brain Interfaces Initiative' and is led by researchers from Radboud University Nijmegen. TU Delft will contribute to the development of computer models, and microfabrication technology for the development and validation of closed-loop control for neural prostheses. These prostheses can give us back lost senses and control, enabling us to bypass injuries and treat an unprecedented range of brain disorders, restoring a better quality of life for deaf, blind, paralyzed and mentally ill people. 

Ultimate applications of the multi-year research include the use of Deep Brain Stimulation on patients with motor and psychiatric disorders, the development of Brain-Computer interfaces that enable communication for people who cannot speak and the deployment of visual implants for the visually impaired and blind. Frans van der Helm and Wouter Serdijn are the leaders of the Delft research project. Frans van der Helm: 'The human brain is the ultimate technical challenge for engineers. It is great to be able to use our technical background and technical capabilities to contribute to a better understanding of, and better interaction with, the human brain.'

The Dutch Brain Interfaces Initiative is the combination of a platform with computer, software and hardware elements, aimed at facilitating closed-loop manipulations in the long term, and brain monitoring in a naturalistic environment, with a neuroscience research program with 3 main objectives: to increase the understanding of the general principles of brain dynamics, to develop strategies to influence, restore or improve those dynamics and the cognitive function they support, and to understand the neural basis of behavior under naturalistic conditions.

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Project proposal UPSIDE, successful in the EU call EIC Pathfinder challenge

The multi-disciplinary and international consortium led by Dr. Tiago Costa, includes ME department PIs Dr. Dante Muratore and Prof. Dr. Ir. Wouter Serdijn, and partners from Belgium, Germany, Italy, Portugal, and the USA. With a total budget of 4.2 M€, the consortium will use the combined expertise in bioelectronics, brain-machine interfaces, focused ultrasound, neurobiology, neurosurgery, and psychiatry to achieve a technological breakthrough towards a personalized treatment for depression.

Project description:

Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients. Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation, deep brain stimulation (DBS) and transcranial focused ultrasound (tFUS) still show poor spatial resolution (ECT, tRMS, tFUS) or low network coverage (VNS, DBS), with average remission rates in clinical trials still lower than 30 %. Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool, and, in the case of neuromodulation-based treatments, to determine the stimulation efficacy and allow for personalized treatment. The UPSIDE project aims to overcome the limitations above by developing a hybrid epidural brain interface (EBI) for high-precision ultrasound neuromodulation (eFUS) and high-fidelity neural recording (eREC) for the personalized treatment of depression.


Happy Secretaries Day!!!

Our congratulations and best wishes!


NWA-ORC project "OBSeRVeD" with co-applicant Sten Vollebregt and Frans Widdershoven granted

A total of 28 consortia will work in interdisciplinary teams on research that will bring both scientific and societal breakthroughs within reach. The entire knowledge chain and societal organisations, including public as well as private parties, will work closely together in these projects. The projects have received funding in the third round of the Dutch Research Agenda programme Research along Routes by Consortia (NWA-ORC).

The ME department plays a lead role in one of the funded consortia:

OBSeRVeD - Odour Based Selective Recognition of Veterinary Diseases

Coordinator: dr. ir. C.A.J. (Cas) Damen - Saxion Hogeschool
Affiliated TU Delft researchers:  dr. ir. Sten Vollebregt (WP-lead) and prof. dr. ir. Frans Widdershoven, EEMCS faculty,  dr. Monique van der Veen – AS faculty

When chickens in a farm become infected or have parasites, specific odours are produced. A cross-disciplinary team will combine innovative sensors, affinity layers, and machine learning to develop and test an electronic nose. This sensitive system can recognize a fingerprint of Volatile Organic Compounds and thus recognise specific diseases at an early stage, when (preventive) measures are most effective. In this project, veterinary health, industry, science professionals and societal organisations will collaborate towards developing a practically applicable poultry health monitoring system to improve chicken and public health, general welfare and reduce antibiotics/chemicals use and the environmental impact of livestock farming.

Lees meer: TU Delft news

Or in English on the NWO website: NWO news

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Neurotechnology development needs a multi-disciplinary environment to flourish

A blogpost in Open Neurosurgey by Dr. Vasiliki (Vasso) Giagka, PhD, Assistant Professor of Bioelectronics, Delft University of Technology, The Netherlands

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TU Delft start wereldwijd onderzoek naar oorsuizen (tinnitus)

Wereldwijd onderzoek naar oorsuizen (tinnitus)

Veel mensen hebben last van een continu geluid in hun hoofd. Tinnitus heet dat. Omdat er eigenlijk nog te weinig bekend is over de oorzaken, is er een wereldwijd onderzoek gestart onder de noemer ‘Tinnitus House’. De hoop is dat er uiteindelijk een remedie wordt gevonden.

Tinnitus wordt ook wel oorsuizen genoemd. Al is die laatste omschrijving een understatement, want de geluiden die sommige mensen horen zijn vergelijkbaar met een vrachttrein die door je hoofd raast. Tinnitus hoor je in een stille ruimte, maar ook met oordoppen op. Dan lijkt het alsof er toch geluid is, maar die waarneming komt van binnenuit. Die geluiden heb je in alle vormen: van zacht tot hard, van hoog tot laag, van continu tot af en toe, in één oor of in beide oren.

Eén op de drie volwassenen ervaart in het dagelijks leven wel eens een duidelijke toon in een oor gedurende een aantal seconden. Ook de zogeheten ‘disco-tinnitus’ is je wellicht bekend: als je oren een tijdlang zijn blootgesteld aan veel lawaai, is er eenmaal in de stilte een ruis of fluittoon te horen in je oren. Uiteindelijk komt hierna gelukkig bij de meeste mensen het gehoorsysteem weer tot rust en dan verdwijnen de geluiden. Echter, veel blootstelling aan harde geluiden kan ertoe leiden dat de ruis of fluittoon permanent te horen blijft.

Overgevoeligheid voor geluid

Heb je last van een van onderstaande vormen van overgevoeligheid voor geluid? Dan kun je ook last hebben van tinnitus.

  • Misofonie. Extreme hekel aan specifieke geluiden, zoals bijvoorbeeld blaffende honden of smakgeluiden.

  • Hyperacusis. Mensen die hieraan lijden zijn overgevoelig voor vaak hoge harde geluiden die als onaangenaam en pijnlijk worden ervaren. Denk aan gillende kinderen, of een alarm dat afgaat.

  • Phonofobie: Hardnekkige, abnormale en niet-realistische angst voor geluid. Deze mensen zijn bang dat normale geluiden hun gehoor beschadigen

Tinnitus is zelden te behandelen

Wat iemand met tinnitus dus hoort, zijn schijngeluiden. Die ontstaan doordat het gehoororgaan of de zenuwbanen – zonder dat er geluiden zijn – signalen doorgeven die in de hersenen de betekenis ‘geluid’ krijgen. Waardoor ontstaat zoiets?

  • Beschadigingen in het laatste gedeelte van het gehoororgaan of veranderingen in de zenuwbanen of hersenen kunnen een oorzaak zijn.
  • Ook spiertjes rond het oor die zich samentrekken of problemen in het middenoor kunnen voor tinnitusklachten zorgen.
  • Andere mogelijke oorzaken zijn afwijkingen aan de bloedvaten in het hoofd en een hoge bloeddruk, die een kloppend of tikkend geluid in het ritme van de hartslag veroorzaken

Tinnitus Retraining Therapy (TRT)

Tinnitus Retraining Therapy (TRT) is één van de weinige wetenschappelijk onderbouwde therapieën voor tinnitus en overgevoeligheid voor geluid. Je leert het hinderlijke geluid van het oorsuizen naar de achtergrond te drukken door het als een normaal geluid te beschouwen waarmee gewoon te leven is. Het maakt gebruik van het feit dat je hersenen ook in staat zijn om bijvoorbeeld het zoemende geluid van een koelkast te negeren.

Deze therapie wordt onder andere aangeboden bij audiciens als Beter Horen en Schoonenberg Hoorsupport.

Gehoorverlies bij tinnitus

Naast de irritante geluiden hoort bij tinnitus ook vaak gehoorverlies. En nog vervelender: tinnitus is helaas zelden te behandelen met geneesmiddelen of een medische ingreep. Klachten kunnen wel wat worden verminderd door de aandacht voor de geluiden in het hoofd te verplaatsen naar bijvoorbeeld andere geluiden.

Hoortoestel met tinnitusmaskering

Er zijn hoortoestellen op de markt die een ruis of andere prettige geluiden genereren, zoals bijvoorbeeld geruis van de zee. Heb je behalve tinnitus ook last van behoorlijk gehoorverlies boven een bepaalde waarde (de audicien kan dit meten), dan kan dit een uitkomst zijn. Een nadeel van de maskering, is dat je hierdoor niet went aan je eigen tinnitusgeluid.

Wereldwijd tinnitusonderzoek

Omdat er eigenlijk nog te weinig bekend is over tinnitus is er een wereldwijd onderzoek gestart onder de noemer ‘Tinnitus House’. Dit onderzoek wordt uitgevoerd door de Stichting BrainInnovations onder supervisie van de Technische Universiteit Delft in samenwerking met de Universiteit van Regensburg (Duitsland), Trinity College Dublin (Ierland) en de University of Otago (Nieuw-Zeeland) en mede gefinancierd door de Stichting TinnitusFree. Het doel is om het tinnitusonderzoek een nieuwe dimensie te geven door (big) data-analyse systematisch te testen met klinische trials.

Meewerken aan het onderzoek naar tinnitus?

Heb je last van tinnitus en wil je meewerken aan dit onderzoek? Op de site van Tinnitus House is meer informatie te vinden over tinnitus en over dit onderzoek. Ook kun je je daar abonneren op hun nieuwsbrief.

Meer informatie over tinnitus vind je ook in het boek Eerste hulp bij oorsuizen van Olav Wagenaar.

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Tiago da Costa appointed as an associate editor for the IEEE Transactions on Biomedical Circuits and Systems.

The primary goal of the journal is to bridge the unique scientific and technical activities of the IEEE Circuits and Systems Society to a wide variety of related areas such as:

  • Bioelectronics
  • Implantable and wearable electronics like cochlear and retinal prosthesis, motor control, etc.
  • Biotechnology sensor circuits, integrated systems, and networks
  • Micropower imaging technology
  • BioMEMS
  • Lab-on-chip Bio-nanotechnology
  • Organic Semiconductors
  • Biomedical Engineering
  • Genomics and Proteomics
  •  Neuromorphic Engineering
  • Smart sensors
  • Low power micro- and nanoelectronics
  • Mixed-mode system-on-chip
  • Wireless technology
  • Gene circuits and molecular circuits
  • System biology
  • Brain science and engineering: such as neuro-informatics, neural prosthesis, cognitive engineering, brain computer interface
  • Healthcare: information technology for biomedical, epidemiology, and other related life science applications.               

Home | IEEE CAS (ieee-cas.org) 

More information on Tiago https://www.tmlcosta.com/


Dante Muratore appointed Associate Editor for TCAS-2

Dante Muratore, assistant professor in the Bioelectronics group, was recently appointed as Associate Editor for IEEE Transactions on Circuits and Systems II.

Congratulations, Dante!

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Heart rhythm expert Natasja de Groot: ‘Every heart is different’

The electrodes in the display cabinet show the technical developments over the last 20 years. The oldest one looks like a kind of small shower head from which four cables emerge, ending in computer mouse-sized plugs. Natasja de Groot used it during her PhD research on heart rhythm disorders in Leiden. The newest electrode is a wafer-thin strip to which three metres of multilayer flat cable are attached to read out the 192 channels simultaneously. The cable was made at TU Delft in the Bioelectronics group of Prof. Wouter Serdijn (Faculty of Electrical Engineering, Mathematics and Computer Science).

Full article;  Heart rhythm expert Natasja de Groot: 'Every heart is different’ (tudelft.nl)


Altijd geld bij de hand, met een betaalchip onder je huid

In de onstuitbare opmars van het contactloos betalen zet een Pools bedrijf de volgende stap: een betaalchip onder de huid, geen apparaat meer nodig. Wie wil dat? Brigitte heeft er al een. De technologie is echter niet wereldschokkend, zegt Wouter Serdijn, hoogleraar bio-elektronica in Delft. Artikel in de Volkskrant, d. 17 december 2021, door Enith Vlooswijk.

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Portret series new Medical Delta professors - Wouter Serdijn

For people with heart, nerve and brain disorders, bioelectronic medicine can make a significant difference. Professor Wouter Serdijn works on these tiny devices. He is a professor at TU Delft and, thanks to Medical Delta, now at Erasmus MC as well. "Technical disciplines often use objective measures, while no two people are the same. It is therefore important to include the subjective side in the design."

In the video below, Wouter Serdijn tells about his Medical Delta professorship:

 

"I have always worked together a lot, but with my appointment in Rotterdam this has become more formalised," says Serdijn. "I now also have the 'right' to walk around there and am part of the information flow. This structure fits in well with how I am used to working. Not starting from existing pigeonholes, but working together at an umbrella level. Medical Delta is a bundle of great people, both technical, medical and clinical-academic. The engineer, medical scientist and therapist form a triangle. Together they can develop what is best for a patient."

How did your interest in the medical field emerge?

"For my graduation project, I worked on hearing aids together with a technology company. I experienced that something that met the technical specifications perfectly, could be totally unpleasant to listen to, and thus collided with the boundaries of the technical domain. Technical disciplines often assume objective measures, while no two people are the same and an individual person will be different tomorrow. It is therefore important to include the subjective side in the design.

How do you contribute to medical science with your knowledge of bioelectronics?

"I do not know exactly how the body works, but I can help measure, examine and control it. I can read and write nerve tracts. One example we are working on is helping people with paralysis regain their posture when sitting or standing and a rudimentary form of walking. This can now be done mainly with a wheelchair or other aids. But I want to know how we can re-energize their own muscles that are still intact but no longer controlled. How can we restore the connection between the brain and muscles? We are about to start clinical trials for this.

I also want to contribute to implantable technology that someone can wear invisibly as much as possible. For example, the so-called cochlear implant. This device enables a deaf person to hear and therefore to develop speech. But these implants still have an external part. You have to take it off when you go swimming or take a shower, for example, and then you don't hear anything anymore. I want to improve that. Though you can engage in conversations with this implant, you cannot listen to music. That can even be a very unpleasant experience. I think that is a shame; not being able to enjoy music is truly a loss. I want to tackle that as well."

How do you see Medical Delta in the future?

"In ten years, Medical Delta will be a scientific plateau. With connections and prestige in The Netherlands, Europe and perhaps the rest of the world. It will be the nerve centre of a lot of activities. The educational component also plays an important role, for example, with the clinical technology degree programme. Very good things and people are already coming out of this and I have high expectations of them. Because science is one part, but training new talent in the combined disciplines, that is the multiplier. Each year, we now have almost a hundred new graduates. They will soon have a greater impact than the Medical Delta professors of today. They are the future."

What is your advice for successful collaboration?

"Stay connected with where you originate from. That is where your value and your strength lies. You have to build a bridge, but stay true to what you are good at. Also, in collaboration, there must be a genuine mutual interest and you must both benefit from it. If you go up to someone and say 'I need this piece of technology from you' or 'this technology needs to go into a patient', it doesn't work. It takes time to understand what is happening on the other side and what the problems are. You also have to find a common language. With me, for example, everything is straight. The components, my diagrams. In biology, everything is curved, for example, cells, tissues and organs. You have to find a way of dealing with it. It is in the shared fascination with the problem that we find each other."

Which other researcher surprised you?

"Multiple researchers, but Chris de Zeeuw of Erasmus MC keeps surprising me. It is an important reason for choosing his department for my second appointment as a professor. He is an inspiring leader. He has great scientific knowledge and knows how to create a group and offer opportunities. He sees the importance of other disciplines for his own and was perhaps generation zero of Medical Delta."

This article is part of a series in which we highlight the nine new Medical Delta professors. Click here for the other portraits that have been published so far. Wouter Serdijn's research contributes to scientific programs, including, including Medical NeuroDelta: Ambulant Neuromonitoring for Prevention and Treatment of Brain Disease and Medical Delta Cardiac Arrhythmia Lab.

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Three Medical Delta professors in micro electronics department

On November 2, nine professors were simultaneously inaugurated as 'Medical Delta professor' at Leiden University, LUMC, TU Delft, Erasmus University and/or Erasmus MC. Among which ME professor Wouter Serdijn and part time professors Natasja Groot and Andrew Webb. With an appointment at at least two of these five academic institutions, they combine technology and healthcare in their professorship.

The nine professors have each earned their spurs in research at the intersection of health and technology. Examples include the use of new techniques to determine the cause of cardiac arrhythmia, how cartilage can be repaired using technology, and how e-health can help with rehabilitation or prevention of illness. The official inauguration follows their earlier appointment as Medical Delta professors. During the inauguration, the professors presented their research and answered questions from young researchers.

See more: https://www.medicaldelta.nl/en


Online conference Neural Interfaces and Artificial Senses (NIAS)

Since 1958 when the first pacemaker was implanted in humans, bioelectronics devices have been increasingly used to interface with different types of tissue, monitor and interact with biological activity. During our continuous endeavors to better study sophisticated neuronal systems we have become more capable of diagnosing and treating various disorders. We are currently emerging in an era where bioelectronic devices are becoming smaller, less invasive and safer, which in turn is being paralleled with new therapies for a vast range of neurological and auto-immune diseases. This opens exciting possibilities for the future, from cutting-edge technology for brain-machine-interfaces with unprecedented functionality, artificial organs and augmented senses that can change the way we perceive the world, to a more human way of interactions with robots.

Topics to be covered by the conference: • Bioelectronic devices • Electroceuticals/Bioelectronic medicine • Neuronal interfaces and implantable electronics • Materials at the interface with biology • Neuronal mechanisms and clinical applications • Artificial visual, auditory, olfactory, gustatory and tactile sensory systems.

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Asli Yelkenci wins CadenceLIVE Europe 2021 award

Asli Yelkenci is the winner of the CadenceLIVE Europe 2021 under the category of “Master Thesis Award for the Best Design using Cadence tools” with her master thesis done at Delft University of Technology under the supervision of Virgilio Valente, Section Bioelectronics.

Her thesis title is “A 16-Channel CMOS Reconfigurable Unit for Simultaneous In-Vitro Microelectrode Array (MEA) and Current-Clamp Measurements” which aims to gain insight into the correlation between electrical activities of a population of cells and single-cell activity. She will present her work during the online event CadenceLIVE Europe 2021 on 19th October.

You can register for the event and see the celebratory video via the link below.

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The rising stars of the TU Delft, featuring Dante Muratore

After his PhD in what he calls “hardcore analogue microelectronics”, rising star Dante Muratore knew he wanted to continue his career working on systems that are closer to an actual application. A postdoc position at Stanford University, in which he worked on the electronics for an artificial retina to treat medical conditions leading to the loss of vision, brought him just that. Then, wanting to come back to Europe and to continue doing bioelectronics at the highest level possible, an opening at TU Delft crossed his path. ‘It was the easiest choice I ever made,’ he says.

Read more about Dante in the link below!

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Ultrasound for microimplants – enabling personalized medicine with wireless charging

Treatment of chronic autoimmune diseases is no longer limited by the expensive drugs and undesirable side effects. Neuromodulation has been shown to be effective in treating diseases such as rheumatoid arthritis, chronic headaches, asthma or Parkinson's disease. To enable the technology for widespread clinical application, researchers at Fraunhofer IZM are developing a new generation of microimplants as part of the EU Moore4Medical project. These highly miniaturized devices have a special feature: the implants can be charged entirely wirelessly using ultrasound waves.

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Assistant professor Tiago Lopes da Costa (Bio electronics) receives the ‘early career HFSP research grant’

Abstract

Cellular communication is mediated by voltage-gated, ligand-gated and mechanosensitive ion channels. Tools for modulating neuronal communication based on focused ultrasound (FUS) were developed to overcome fundamental limitations in optogenetics, combining non-invasive approaches and high spatial resolution without the need for genetic modification of neurons. Yet, little is known about the fundamental mechanisms of how focused ultrasound waves influence the finely tuned interplay of ion channels and lipid bilayers. How does the frequency and intensity of the ultrasound wave affects the lipid bilayer and different types of ion channels? What is the physical mechanism that governs the triggering of ion channel activity? These questions remain unanswered, with existing hypothesis limited by the spatio-temporal resolution of traditional optical, electrophysiology and ultrasound tools, which prohibit observations at the single ion channel level. To answer these questions we hypothesize that, if there would be a way to monitor effects of the FUS on the lipid bilayer and single ion channels with high temporal resolution, one should be able to monitor ultrasound-evoked oscillating current responses informing on ultrasound neuromodulation mechanisms. Hence, the aim of this proposal is to develop a concurrent experimental and computational approach, where state-of-the-art ultrasound and current read-out devices enabling high-bandwidth electrophysiology are matched with computational electrophysiology simulations. This will allow us for the first time to match the frequency of the focused ultrasound with the bandwidth of single ion channel recordings and the length of the computer-based simulations. We will focus our efforts in three aims, where Aim1 will establish the recording systems and simulations using model membranes alone and a mechanosensitive model channel. In Aim2 we will develop a recording platform integrating US-stimulation and high bandwidth recordings in complementary metal-oxide semiconductor (CMOS) technology, extending our efforts on non-mechanosensitive channels. In Aim3, we will combine the gained knowledge from Aims 1 and 2 to focus on mechanosensitive channel that are hypothesized to be involved in neuromodulation.


"Tech for Health" featuring Natasja de Groot

Please donate to our research on better understanding of cardiac arrhythmia

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Profcast with Prof. Wouter Serdijn

Or visit this link


Webinar with dr. Vasso Giagka: "Lowering the Barrier for Customized Micro Systems in Medical Applications"

Webinar: "Lowering the Barrier for Customized Micro Systems in Medical Applications" Dear EUROPRACTICE member, We are delighted to invite you to a webinar organized by EUROPRACTICE together with flanders.health dedicated to lowering the barrier for customized micro systems in medical applications, which will take place online on March 24, 2021, from 14:00 to 16:00 CET. If you have been following the trends in medical innovations in recent years, you know that microelectronic solutions are revolutionizing the MedTech industry and improving the quality of delivered healthcare and thus patient life tremendously. Whether it is artificial intelligence (AI), augmented reality (AR), or sensing, microelectronic systems play a key role in accelerating these trends in the medical world. For MedTech companies, it is important that microelectronic systems can be customized, but typically this comes at a high cost.

This is where EUROPRACTICE comes in. The consortium lowers the barrier for customized microsystems by providing affordable access to design tools, fabrication services, and training. If you are interested in learning more about how customized microsystems can make the difference for your medical application, then invest 2 hours of your time to learn about EUROPRACTICE and its affordable services. In this webinar, we will particularly zoom in on Application-Specific Integrated Circuits (ASICs) and Photonic Integrated Circuits, and how those can be fabricated and integrated in microsystems for medical applications. The latter will be illustrated by several testimonials/case studies presented by both academia and industry.

Webinar Agenda

1. Introduction by flanders.health

2. “Overview of Micro Systems in Medical Applications and how EUROPRACTICE can lower the barrier to technology access” - Romano Hoofman (imec)

3. Case Studies

Steve Stoffels (Pulsify Medical) – “Pulsify’s ultrasound monitoring patch: future medical grade wearables enabled by custom components.”

Jan-Willem Hoste (Antelope Dx) – “Antelope Diagnostics: Bringing photonic chip technology to a consumer market”

Pieter Harpe (TU Eindhoven) – “Custom microelectronics for ambulatory pregnancy monitoring and ultrasound catheters”

Vasiliki Giagka (TU Delft) – “Microelectronic chips for bio-electronic medicine: Engineering long-lasting and spatially selective active neural implants”

Bob Puers (KU Leuven) – “Concept for a high resolution neural interface with polymer-CMOS hybrid interconnects”

4. Q&A

Register https://share.hsforms.com/1sMh30WWDQzi-2-_qMcq9OQ42q9f?utm_medium=email&_hsmi=114173729&_hsenc=p2ANqtz-_J0UTBpWNtB6-mAe-UvA_dkxZRlerg6ZC5tgyAS8t3UFTXI7bZqdR5oHS-50jKN_SVQoHXjUVVGCmXsr2KSch9lKtT6g&utm_content=114173729&utm_source=hs_email


INESC MN 2021 Seminar Series - Dr. Tiago Costa, March 5, 16.00 PM

Neurological disorders are the leading cause of disability and the second leading cause of death, worldwide. Still, a paradigm exists in the available therapies: while pharmaceutical drugs are non-invasive but have poor precision and low effectiveness in the long term, therapies based on implantable electrical stimulators have high precision but are also highly invasive, which reduces patient eligibility. For the first time, a minimally invasive and precise neuromodulation modality is emerging through low intensity focused ultrasound (LIFU). However, the hand-held form-factors of existing ultrasound technology, together with its spatial resolution still being 10x lower than implantable electrodes, are hampering advances in both fundamental neuroscience research and the translation to the clinic. In this talk, I will describe my research on stand-alone ultrasonic microchips, by exploring the co-design and integration of CMOS circuits and piezoelectric materials. With massive miniaturization, focused ultrasound can be delivered through more efficient methods (wearable, injectable) while supporting higher ultrasound frequencies towards higher spatial resolution. These advances will contribute to a new generation of ultrasound technology to bring LIFU neuromodulation to the forefront of neuroscience and neurology.

To register see link below:

https://sites.google.com/site/inescmn/home/news


Cardiac mapping of very young children reveals conduction disorders related to atrial fibrillation

Research of Medical Delta professor prof. dr. Natasja de Groot (Erasmus MC and TU Delft)

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Delft Bioengineering Institute awards Tiago Costa and Massimo Mastrangeli with 20KEUR grants

Dr. Tiago Costa (BE) and Dr. Massimo Mastrangeli (ECTM) have been awarded grants of 20KEUR by the Delft Bioengineering Institute (BEI) to pursue their research projects on ultrasound-based regeneration of neuronal circuits and medical implants to investigate cell mechanobiology, respectively.
Their multidisciplinary project proposals, conceived to bridge expertise among different departments within TU Delft, are among the 5 selected for the grants out of the 13 total submissions received by the BEI in response to their first call for proposals.
The projects will be run respectively in collaboration with Dr. Dimphna Meijer (TNW/BN) and Dr. Mohammad J. Mirzaali (3mE/BM).
Below are short summaries of the projects.

Regenerating neuronal circuits using ultrasound

People suffering from neurodegenerative disorders such as Alzheimer’s, Parkinson’s Disease and Multiple Sclerosis, have impaired neuronal circuits. Generation of new neuronal circuits by using a patient’s own stem cells may prove helpful in treating the disease. One of the difficulties in inducing neurons from stem cells, is the low efficiency rate we are able to achieve so far. In this project, BEI PIs Tiago Costa of Microelectronics (EWI) and Dimphna Meijer of Bionanoscience (TNW) join forces to explore the use of ultrasound for effectively building active neuronal networks from stem cells.

Project title: SoundCircuit: Regeneration of neuronal circuits using ultrasound
BEI PIs: Tiago Costa (EWI/ME), Dimphna Meijer (TNW/BN)

Medical implants to investigate cell mechanobiology

In order to study the cell’s behavior and differentiation, we need to be able to measure the mechanical, electrical, and biochemical signals that are dynamically transmitted throughout the cells. This requires the creation of biomaterial models equipped with different sensor types. In this project, BEI PIs Mohammad J. Mirzaali of Biomechanical Engineering (3mE) and Massimo Mastrangeli of Microelectronics (EWI) will team up to design, fabricate and test the proof-of-concept for medical implants equipped with force sensors that can reach a sensitivity level of one micronewton, so the mechanobiology of cells can be effectively investigated.

Project title: Sixth Sense Biomaterials
BEI PIs: Mohammad J. Mirzaali (3mE/BM), Massimo Mastrangeli (EWI/ME)

Read the full story on the TU Delft page.

Success!


Microimplants: electricity instead of pills

Interview in MEDICA Magazine with Prof. Vasiliki Giagka, Group Leader "Technologies of Bioelectronics", Fraunhofer Institute for Reliability and Microintegration IZM and Assistant Professor of Bioelectronics, Delft University of Technology

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New sensor chips; low-cost, smart and efficient

In a greenhouse, cucumbers are growing beautifully. A grower is cultivating them under the most favourable conditions, closely monitoring the precise amount of water they need and whether the temperature is optimal, to ensure that the cucumbers that end up on your plate are juicy, flavoursome and green. The grower’s job is by no means carefree, however. What if the crop is blighted by some disease? One of the strategies that researchers are working on to prevent this involves an “electronic nose”. All plants, cucumbers included, emit a scent. An electronic nose can immediately detect whether something is wrong. The same technique can be applied in a chicken coop or cowshed. As soon as a disease breaks out, the electronic nose will detect it and give a warning.

For complete article;

https://www.tudelft.nl/en/stories/articles/new-sensor-chips-low-cost-smart-and-efficient/


Treating your disorder with electronic medicines

Increasing numbers of people now have a chip in their body which they can use to make payments or check in to public transport. “It sounds futuristic, but the technology is not that extraordinary”, explains Prof. Wouter Serdijn. “My dog has something similar.”

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SSCS WYE Webinar

Webinar: To Academia, or to Industry, That is the Question. Presented by: Kofi Makinwa and Shin-Lien Lu

Abstract:

You are about to finish graduate school or perhaps a young or seasoned professional, contemplating a career transition. Which is better - a career in academia or industry? What are the pros and cons of one versus the other? How can you start exploring and build up your career accordingly? In this webinar, we will interview Dr. Linus Lu, a professor-turned-industry veteran, and Prof. Kofi Makinwa, an industry veteran-turned-professor, who will share their insights and perspectives from their personal journeys in both academia and industry careers. They will also address what triggered their transitions, how they staged their transitions, and offer their crystal ball projections on present and future career prospects in the solid-state-circuits profession.

REGISTER TODAY!

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Moore4Medical kicks off

The ECSEL Joint Undertaking Moore4Medical kicked off last June, 2020 with the overarching objective to accelerate innovation in electronic medical devices. Moore4Medical is masterminded by prof. Ronald Dekker (Philips Research & ECTM) and sees important involvement and vast opportunities for TU Delft’s Microelectronics department.

The project addresses emerging medical applications and technologies that offer significant new opportunities for the Electronic Systems & Components (ECS) industry, including: bioelectronic medicines, organ-on-chip, drug adherence monitoring, smart ultrasound, radiation free interventions and continuous monitoring. The new technologies will help fighting the increasing cost of healthcare by reducing the need for hospitalisation, helping to develop personalized therapies, and realising intelligent point-of-care diagnostic tools.

Moore4Medical will bring together 66 selected companies, universities and institutes from 12 countries who will develop open technology platforms for these emerging fields to help them bridge “the Valley of Death” in shorter time and at lower cost. Open technology platforms used by multiple users for multiple applications with the prospect of medium-to-high volume markets are an attractive proposition for the European ECS industry. The combination of typical MedTech and Pharma applications with an ECS style platform approach will enhance the competitiveness for the emerging medical domains addressed in Moore4Medical. With value and IP moving from the technology level towards applications and solutions, defragmentation and open technology platforms will be key in acquiring and maintaining a premier position for Europe in the forefront of affordable healthcare.

TU Delft’s Microelectronics department leads two of the six workpackages represented in Moore4Medical: the Implanatable Devices workpackage, led by Dr. Vasiliki “Vasso” Giagka (BE & Fraunhofer IZM), and the Organ-on-Chip workpackage, led by Dr. Massimo “Max” Mastrangeli (ECTM). Both workpackages will see the interaction and contribution of many world-class industrial and academic players to develop respectively bioelectronic medicines and smart multi-well plate platforms, and will provide a rich opportunity to capitalize on and further expand the standing expertise of the BE and ECTM groups of the department.

We wish Moore4Medical success!

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Andra Velea wins Audience Award of the Young Medical Delta Thesis Awards

We are proud to announce that the MSc thesis of Andrada Velea on the development of 'Flexible Passive and Active Graphene-based Spinal Cord Implants' won the audience award of the Young Medical Delta Thesis Awards 2020 with 418 out of the 1024 votes. The research theme is a successful synergy of the expertises of the ECTM and BE sections, and was supervised by Vasiliki Giagka and Sten Vollebregt. Andrada’s work has led to 2 IEEE conference publications, among which the prestigious 33rd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2020), which took place earlier this year in Vancouver. We would like to congratulate her for this great achievement.

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Medical Delta Professors appointed

Medical Delta appointed 9 new MD Professors, with joint appointments at LUMC and TU Delft, or Erasmus MC and TU Delft. Three of these are connected to the MicroElectronics Department: Wouter Serdijn, Andrew Webb, and Natasja de Groot.

Prof. Dr. Natasja de Groot (Erasmus MC, TU Delft) researches the use of sensors and catheters to more accurately diagnose and treat cardiac arrhythmias. At TU Delft, she will have an affiliation with CAS and BE.

Prof. Dr. ir. Wouter Serdijn (TU Delft, Erasmus MC) researches the use of bioelectronics in medical research. At EMC, he will have an affiliation with Neuroscience.

Prof. Dr. Andrew Webb (LUMC, TU Delft) researches how imaging can be more widely available for medical purposes. He is a professor in MRI at LUMC, and already had a part-time appointment at CAS.

The new Medical Delta professors introduce themselves and their research in a short video. This can be viewed here:

 

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Professor Wouter Serdijn appointed as Medical Delta Professor

Since 2011 Medical Delta professorships have been established and approved by the executive board of Delft University of Technology, Erasmus University Rotterdam and Leiden University. At the moment 13 professors are active as Medical Delta professor.

A Medical Delta professorship is an honorary title for those who meet the requirements that they have double appointments at, at least, two of the three universities participating in Medical Delta and are active in research and teaching in a way that makes a Medical Delta appointment appropriate.

In the last year the board of Medical Delta together with the scientific council of the Medical Delta and governors of the academic knowledge institutes developed a process to identify the professors that fulfil these criteria. Based on this process a number of professors have been identified to be eligible for this honorary title of which professor Wouter Serdijn is one.


Kleine Stromstöße mit heilsamer Wirkung (Eng: Small surges of electricity with a healing effect)

Winzige Chips statt Medikamente – leitet die „Bioelektronik“ eine neue Ära der Medizin ein? Ein Überblick über die neuen Ansätze (Eng: Tiny chips instead of medication - does "bioelectronics" usher in a new era of medicine? An overview of the new approaches). Article by Susanne Donner with, a.o. Vasiliki Giagka in Der Tagespiegel.

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How smart sensors can prevent epilepsy

In Delft and Rotterdam, Wouter Serdijn and Christos Strydis are collaborating on a network of sensors and stimulators for the body. By picking up signals and sending the brain a rapid wake-up call, they hope to be able to predict and prevent epileptic fits. ‘If we can close the loop, we’ll have the technology ready within three years.’ Article in Nodes, with Christos Strydis and Wouter Serdijn.

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Therapies without drugs -- Tech News

Fraunhofer researchers Tim Hosman and Vasiliki Giagka are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master.

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Student Alberto brings wireless monitoring a step closer

In September 2017 Alberto Gancedo started his master programme Microelectronics at the Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS). Alberto’s ambition was bigger than obtaining his degree. His ambition was to develop a small, portable and cheap monitoring device to detect unusual brain activity in premature babies directly after birth. Thanks to donations from EEMCS alumni, Alberto could start his master’s at TU Delft and work towards this ambition. Alberto graduated in the beginning of February 2020 and proudly updates Delft University Fund and EEMCS alumni about his achievements.

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Christos Strydis winner of the Delft Health Competition

During the Future Health at TU Delft Symposium of January 23, Christos Strydis (Computer Engineering, Bioelectronics and Neuroscience) won one of the three prizes of 10,000 Euro in the Delft Health Competition.

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"The Rising Stars of TU Delft" featuring Tiago da Costa

Delft Health Initiative introduces "The rising stars of the TU Delft". Here we present stories of talented researchers, assistant and associate professors in the field of healthcare. The goal is to get to know the rising stars, read about their research and ambitions, and look for collaborations. Click below for the story of rising star Tiago da Costa.

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Call for Papers: Bioelectronic medicine: engineering advances, physiological insights, and translational applications

Special issue of Bioelectronic Medicine, edited by Vasiliki Giagka, Stavros Zanos, Timir Datta-Chaudhuri, Loren Rieth, and Theodoros Zanos

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Wouter Serdijn appointed theme leader of Delft Health Initiative 2.0's NeuroTech theme

The Delft Health Initiative has laid the foundation for connected health-oriented research at TU Delft and will continue to focus expertise, develop talent and to connect researchers to national and international initiatives. Wouter Serdijn will lead this for Neurotechnology.

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Integrated devices for neuronal ultrasound stimulation

Neuronal interfaces have been widely developed in last decades with the purpose of providing a path for communication with the nervous system. The most common neuronal interfaces are based on electrical recording and stimulation of neuronal activity, which typically require surgical implantation of electrodes to achieve the necessary spatial resolution. To overcome the many hurdles and risks of surgery, non-invasive techniques to interface with the nervous system are currently being developed, and one of the most promising techniques uses focused ultrasound as a neuromodulation therapeutic modality. Due to its non-invasiveness, to achieve the necessary high spatial resolution, comparable to implantable electrodes, ultrasound transducers and electronics must be integrated in the same device. Its success may lead the way to surgery-free neuro-prosthetics and electroceuticals.

Read more on Pages 29-31 of ETV's Maxwell 22.4

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Het medicijn van de toekomst slik je maar een keer en is bioelektronisch

Item op BNR Nieuwsradio van 15 juli 2019, met een bijdrage van Wouter Serdijn over het onderzoek op bioelektronische medicijnen zoals onderzocht worden aan de TU Delft

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Open Course Analog Integrated Circuit Design No. 1 in Microelectronics and No. 2 in Electrical Engineering

Analog Integrated Circuit Design is an introductory course in analog circuit synthesis for microelectronic designers. Topics include: Review of analog design basics; linear and non-linear analog building blocks: harmonic oscillators, (static and dynamic) translinear circuits, wideband amplifiers, filters; physical layout for robust analog circuits; design of voltage sources ranging from simple voltage dividers to high-performance bandgaps, and current source implementations from a single resistor to high-quality references based on negative-feedback structures.

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Asli Yelkenci wins BioEl 2019 best poster presentation

Asli presented her approach for co-integration of planar patch-clamps and microelectrode arrays in the same device, thus enabling for high-throughput simultaneous intra- and extra-cellular measurements of cardiac cells. Asli received a prize of 300 Euros sponsored by Panaxium.

Ref: A. Yelkenci, R. Martins da Ponte, V. Valente. Co-integration of flip-tip patch clamp and microelectrode arrays for in-vitro recording of electrical activity of cardiac cells. Presented at the 2019 Winterschool on Bioelectronics, Kirchberg, Austria, 16-23 March 2019.


Vasiliki Giagka appointed associate editor for Bioelectronic Medicine

Bioelectronic Medicine (BM) is an open access, peer reviewed and relatively young journal published by the Feinstein Institute for Medical Research (in New York, NJ, USA) on BMC’s platform (part of Springer Nature): https://bioelecmed.biomedcentral.com. The journal brings together material science, molecular medicine, bioengineering, neuroscience, computer science and other related disciplines focused on new insights into the role of the nervous system in disease and health, and the importance of discovering new molecular mechanisms and technologies to treat disease. The journal has an expanded community and multidisciplinary audience from healthcare, technology and scientific research. Specialists writing for BM come from fields such as neuroscience, biology, bioengineering, electronics, computing, data analytics, molecular medicine, pharmaceuticals, medical devices, and personalized medicine and last named is extremely important in the upcoming domain of bioelectronic medicine, also known as electroceuticals, the electronic counterparts of pharmaceuticals.

At the core of electroceuticals is the electrical signal used by the nervous system to communicate information. Virtually every cell in the body is directly or indirectly controlled by these neural signals. Bioelectronic medicine technologies can record, stimulate and block neural signaling. Through its ability to manipulate neural signals it will change the way physicians treat diseases and conditions such as rheumatoid arthritis, Crohn's disease, diabetes, paralysis, bleeding and even cancer.

All articles published by BM are made freely and permanently accessible online immediately upon publication, without subscription charges or registration barriers. This nicely aligns with Delft University of Technology’s Open Acces policy.

For the same journal, Wouter Serdijn (also Section Bioelectronics at Delft University of Technology) has agreed to be serving as contributing editor. In this role, he will advise the editors of new trends, which may soon become prevalent in the field; keep up-to-date with the journal’s publications and provide feedback to the editors; contribute topic ideas and manuscripts to thematic series that will be implemented by the journal in the future; recommend articles from the field for publication.


Wouter Serdijn nieuw lid Wetenschappelijke Raad Medical Delta

Als lid heeft Wouter Serdijn de taak om bij te dragen aan het creëren van het wetenschappelijk programma en daarmee aan de visie van Medical Delta. Hij helpt mede vorm te geven aan onderzoeksprogramma’s en zal als ambassadeur optreden. Serdijn: “Met diverse langlopende samenwerkingen met zowel het ErasmusMC en het LUMC waren EWI en mijn sectie Bioelectronics al ‘Medical Delta’ vanaf het eerste uur. Niet zo verwonderlijk, want het behouden en terugwinnen van 100% gezondheid gerelateerde kwaliteit van leven vraagt steeds vaker micro-elektronische ondersteuning. Deze ondersteuning is belangrijk, zowel voor het begrijpen van de menselijke fysiologie en het menselijk gedrag als voor het betrouwbaar stellen van een diagnose, voor het nauwkeurig en ongestoord monitoren en voor een succesvolle persoonlijke behandeling. Ik denk dat dit goed aansluit bij de missie van Medical Delta en ik draag namens EWI graag een steentje bij.”

Medical Delta is een netwerk van life sciences, gezondheids- en technologie-organisaties. Gevestigd in de Nederlandse Rijndeltaregio bundelen zij een brede kennis en ervaring en fungeren als katalysator voor innovatie en samenwerking op het gebied van gezondheid.

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First Microelectronics Synergy Grants

According to Professor Geert Leus who heads the ME Research Committee, the Synergy Grants are also intended to kick-start the research of young faculty, as it can be quite challenging for them to obtain funding at the beginning of their research careers. The grants cover half the costs of a PhD candidate, with the rest coming from existing research funding. ‘The submitted proposals were carefully evaluated by the ME Research Committee on the basis of their scientific quality, their clarity and feasibility, the synergy between the participating sections, and the relationship to the departmental themes. The ME Management Team (MT) then decided to award Synergy Grants to the top three proposals.’

Changes

The aim of the grants is to encourage newly emerging combinations of technologies and to facilitate cross-overs between them, thus strengthening and broadening the department's research portfolio. This goal fits seamlessly within the research strategy of ME, which has defined itself around the four themes of Health & Wellbeing, XG, Safety & Security and Autonomous Systems to better address societal challenges.

Winners

Last week, the winners were received by the ME MT. They received flowers from the head of the department (Kofi Makinwa) and had the opportunity to briefly present their proposals to the assembled MT. Below are short descriptions of the successful proposals.

Akira Endo & Sten Vollebregt: ‘The aim of our project TANDEM: Terahertz Astronomy with Novel DiElectric Materials is to develop advanced dielectric materials to realize superconducting microstrip lines with very low losses in the frequency ranges of 2-10 GHz and 100-1000 GHz. The PhD candidate will combine the dielectric deposition, characterization, material expertise and facilities of the ECTM group and the Else Kooi Laboratory, and the submillimetre wave device measurement capability of the THz Sensing Group and SRON. The aim is not only to realize low loss dielectrics, but also to understand the underlying physics that governs these losses. If successful, these microstrips will be immediately applied to enhance the sensitivity of the DESHIMA spectrometer on the ASTE telescope in Chile.’

Bori Hunyadi: ‘On one hand, the vast complexity of the human brain (10^11 neurons and 10^14 connections) enables us to process large amounts of information in the fraction of a second. At the same time, imperfections of the wiring in this vast network cause devastating neurological and psychiatric conditions such as epilepsy or schizophrenia. Therefore, understanding brain function is one of the greatest and most important scientific challenges of our times. Brain function manifests as various physical phenomena (electrical or e.g. metabolic) at different spatial and temporal scales. Therefore, the PhD candidate working on this grant will develop a novel multimodal and multiresolution brain imaging paradigm combining EEG and a novel imaging technique, fUS. The specific engineering challenge is to understand and describe the fUS signal characteristics, deal with the large amount of data it records using efficient computational tools; and finally, formulate the specification of a dedicated non-invasive, multimodal, wearable EEG-fUS device.’

Virgilio Valente & Massimo Mastrangeli: ‘The seed money of the Synergy Grant will partially support a joint PhD candidate to investigate the tight integration of an heart-on-chip device with dedicated electronic instrumentation in the same platform. Our aim is to bring sensing and readout electronics as close as possible to a cardiac tissue cultivated within a dedicated micro physiological device. The grant helps promoting the logical convergence between current departmental research activities at ECTM and BE and within the Netherlands Organ-on-Chip Initiative (NOCI) on the development of instrumented organ-on-chip devices.’


Microelectronics at work for sustainable healthcare

The Medical Delta has launched twelve research programmes that work on technological solutions for sustainable care. EEMCS is represented in three programmes; Neurodelta (Wouter Serdijn), Medical Delta Cardiac Arrhythmia Lab (Wouter Serdijn and Alle-Jan van der Veen) and Ultrafast Ultrasound for the Heart and Brain (Michiel Pertijs), all part of the Microelectronics department.

In order to give the research programmes an extra impulse, a strategically important project is financed within each research programme.

In the Medical Delta 2.0 Neurodelta program Vasiliki Giagka and Wouter Serdijn (both Section  Bioelectronics) will work on miniature implants for simultaneously measuring and influencing brain activity by means of light and ultrasound.

Read more about Vasiliki Giagka's work: https://www.tudelft.nl/ewi/actueel/nodes/stories/elektrische-implantaten/

 

Within the Medical Delta 2.0 Cardiac Arrhythmia Lab, Virgilio Valente (Section Bioelectronics) and Richard Hendriks and Borbala Hunyadi (both Section CAS) will work on new bioelectronic signal acquisition and processing techniques to identify the electropathology of cardiac dysrhythmia, such as atrial fibrillation, in an organ-on-chip set-up.

Read more about the work of Virgillio Valente: https://bme.weblog.tudelft.nl/2018/12/11/biocmos/ 

 

Within the Medical Delta 2.0 programme Ultrafast Ultrasound for the Heart and Brain, Michiel Pertijs (Section Electronic Instrumentation) will work on smart ultrasound probes that can take 3D images of the heart and brain at high speed, with the aim of enabling new and better diagnostics of cardiovascular and neurological disorders.

Read more about the work of Michiel Pertijs: https://www.tudelft.nl/ewi/actueel/nodes/stories/echos-uit-een-pleister/    

 

More information about Medical Delta: www.medicaldelta.nl/news/overzicht-programmas-medical-delta-20192023


Health Prototype Grant for Virgilio Valente

The TU Delft Health Initiative objective is to promote research in the field of healthcare at Delft University of Technology and they granted 13 out of total 26 applications. ‘Organs-on-chip (OoC) systems represent the new frontier in biomedical engineering, aiming at re-producing and mimicking key aspects of living organs on microengineered biosystems, by modeling the structural and functional complexity of organs, tissue to tissue interactions and cellular metabolism. Coupled to microfluidics and multi-parameter sensing, OoCs promise a significant revolution in the development of future targeted drugs and therapies, by providing a vital alternative to conven-tional cell cultures and animal models. By leveraging the distinctive features of modern complemen-tary metal-oxide semiconductor (CMOS) technology, coupled with high-density microelectrode array (MEA) systems, we can develop complex yet com-pact microelectronic biodevices capable of interact-ing with biological networks at a single-cell scale with unprecedented resolution and sensitivity. Im-pedance-based measurements (IM) have shown significant potential in monitoring cell and tissue contractions, morphology and cell-to-cell heteroge-neity. Impedance assays are currently routinely developed to assess drug toxicity in cardiac cell cul-tures. Commercial systems, including the xCELLI-gence RCTA by ACEA Biosystems, are based on the use of two electrodes for IM, which greatly limits the measurement resolution. To date, there is no com-mercial or research system capable of measuring impedance profiles from cardiac cell culture with high resolution.’

Read more about the work of Virgillio Valente: https://bme.weblog.tudelft.nl/2018/12/11/biocmos/


BioCMOS

The new frontier in smart and efficient diagnostics and analytics is represented by the fusion of semiconductor technologies and electrochemical sensors. BioCMOS devices, also known as Lab-on-CMOS or CMOS biosensors, consist of microelectronic interfaces with integrated high-density sensing elements. On top of these elements, biological and chemical assays can be directly performed, limiting considerably the need for additional external units. The Bioelectronics group is currently developing BioCMOS microsystems that target applications, including lab-on-chip and organ-on-chip platforms, point-of-care devices, implantable and injectable smart biosensors. By leveraging the distinctive features of modern complementary metal-oxide semiconductor (CMOS) technology, we can develop complex yet compact microelectronic bio-devices capable of interacting with biological networks at a cellular and molecular scale with unprecedented resolution and sensitivity. BioCMOS technology promises to play a key role in defining future targeted therapies and personalized medicine, cost-effective drug discovery and development, and efficient disease management strategies. Read more on Page 18-21.


Bioelectronic Medicine

Imagine a tiny device that can treat patients by injecting small electrical pulses into the neuronal tissue. These tiny microelectronic devices are the main focus of a new exciting field called Bioelectronic Medicine, with the main goal of one day replacing conventional chemical drugs. When implanted, these devices can act on the body’s nervous system to treat a wide variety of disorders, such as rheumatoid arthritis, obesity, Crohn’s disease, migraine, epilepsy, etc.[1] .The technological challenges behind realizing such devices, however, are enormous and encompass almost every facet of microfabrication and bioengineering technologies. Read more on Page 6, 7 and 8.


Volgens de wetenschap kunnen doven straks horen en blinden zien

Er staan veel filmpjes online van emotionele mensen die, met behulp van moderne technologie, voor het eerst hun familie kunnen zien. Of van kinderen die voor het eerst de stem van hun ouders horen. Het zijn voorbeelden van de eerste stappen naar het genezen van blindheid. Prof. dr. Wouter Serdijn doet onderzoek naar het ontwikkelen van bio-elektronica met als doel het behandelen van deze menselijke kwalen. Artikel in het AD van 26 oktober 2018.

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Vacancy: Assistant/Associate Professor of Bioelectronics

Assistant/Associate Professor of Bioelectronics

Faculty: Electrical Engineering, Mathematics and Computer Science
Required Level: Completed PhD
Appointment: 32-38 hours per week
Contract duration: Tenure
Salary: 3545 - 5513 Euro per month (1 fte)

Faculty Electrical Engineering, Mathematics and Computer Science


The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) is known worldwide for its high academic quality and the social relevance of its research programmes. The faculty’s excellent facilities accentuate its international position in teaching and research. Within this interdisciplinary and international setting the faculty employs more than 1100 employees, including about 400 graduate students and about 2100 students. Together they work on a broad range of technical innovations in the fields of sustainable energy, telecommunications, microelectronics, embedded systems, computer and software engineering, interactive multimedia and applied mathematics.


The Department of Microelectronics has a strong interdisciplinary research and education programme in the areas of 1. health and well-being, 2. autonomous systems, 3. next generation wireless and sensing technology and 4. safety and security.


With 11 IEEE Fellows among the staff, an excellent microfabrication infrastructure, electrical and physical characterisation facilities, and a strong international academic and industrial network, the department provides high-level expertise in each of these areas throughout the entire system chain.


The Section Bioelectronics is a relatively new section that has been created to address coherently the challenges we face in developing bioelectronic medicine and electroceuticals. The group conducts research, education and valorisation in the fields of circuits and systems for active wearable, implantable and injectable biomedical diagnostic, monitoring and therapeutic microsystems. The group is active in the domains of biosignal acquisition, conditioning and detection, electrical stimulation, transcutaneous wireless communication and power transfer, energy harvesting, bioinspired circuits and systems, CMOS diagnostic systems, flexible implants and microsystem integration.

Job description

The Bioelectronics group is offering a tenure-track position at the Assistant or Associate Professor level in the field of biomedical circuits and systems. You will further develop existing research topics, such as mixed-mode and digital circuits and systems for active wearable and implantable medical devices and create new topics, which may include bioelectronic medicine. You will be involved in teaching at the BSc and MSc levels in the TU Delft's Electrical Engineering and Biomedical Engineering programmes and the Leiden-Delft-Erasmus Technical Medicine programme. Collaborative initiatives are strongly encouraged. You are expected to write research proposals for national and international funding organisations. This is a tenure-track position for a period of five years with the possibility of a permanent faculty position at the end of the contract, subject to mutual agreement.


A Tenure Track, a process leading up to a permanent appointment with the prospect of becoming an Associate or Full Professor, offers young, talented academics a clear and attractive career path. During the Tenure Track, you will have the opportunity to develop into an internationally acknowledged and recognised academic. We offer a structured career and personal development programme designed to offer individual academics as much support as possible. For more information about the Tenure Track and the personal development programme, please visit www.tudelft.nl/tenuretrack.

Job requirements

You must have a PhD degree in the field of biomedical circuits and systems (BioCAS) and some years of experience as a post-doc or university professor. You have an excellent academic track record, reflected by peer-reviewed journal publications, conference contributions, and international research experience. An affinity for working on the interface with other disciplines (biomedical engineering, neuroscience, electrophysiology, biomedical signal processing, etc.) and with clinicians and medical researchers is preferred. You should have a demonstrated ability to initiate and direct research projects and to obtain external funding. Experience in teaching and mentoring of students is required. A teaching qualification is recommended. Demonstrated ability in written and spoken English is required.

Employment conditions

At the start of the tenure track you will be appointed as Assistant Professor for the duration of six years. Section leader, department leaders and you will agree upon expected performance and (soft) skills. You will receive formal feedback on performance and skills during annual assessment meetings and the mid-term evaluation. If the performance and skills are evaluated positively at the end of the tenure track, you will be appointed in a permanent Assistant Professor position.


TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.


TU Delft sets specific standards for the English competency of the teaching staff. TU Delft offers training to improve English competency.


Inspiring, excellent education is our central aim. If you have less than five years of experience and do not yet have your teaching certificate, we allow you up to three years to obtain this.

Information and application

For information about this vacancy, you can contact Prof. Wouter Serdijn, email: W.A.Serdijn@tudelft.nl.


For information about the selection procedure, please contact Mrs. L.M. Ophey, HR-Advisor, email: hr-eemcs@tudelft.nl


To apply, please submit by email a detailed CV that includes a list of publications, contact information of at least three scientists whom we can contact for letters of recommendation, and a research and teaching statement along with a letter of application by November 30, 2018 to: hr-eemcs@tudelft.nl.


When applying please mention vacancy number EWI2018-28.




The Medicine of the Future you take only once, and it is Bioelectronic

Guess what rheumatoid arthritis, Crohn's disease, blindness, deafness and paralysis have in common; they all can be successfully treated with bioelectronic medicine. In this 30 minute presentation at the Delft University Health College prof. Wouter Serdijn explains why and how. https://www.youtube.com/watch?v=Odj1sIVaXhs

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Van Droom naar Daad

Interview van Studium Generale met Wouter Serdijn over de menselijke cyborg.

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Hoe verbeteren chips het menselijk lichaam?

Ruim 200 Nederlanders lopen al rond met een chip in hun lichaam, en het aantal groeit. Dat kan voor allerlei doeleinden zijn, van gemak tot verbetering van de kwaliteit van leven. Interview met Tom Oudenaarden en Wouter Serdijn op NPO Radio 1, woensdag 27 juni 2018.

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Analog Integrated Circuits No. 1 OCW course in Microelectronics, No. 2 in Electrical Engineering

And again our Open CourseWare course Analog Integrated Circuit Design (ET4252) has the most page views of 2017. 14,790 page views!

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Objectief en gericht behandelen van patiënten met elektroceutica

Medici grijpen vaak naar farmaceutische middelen om een kwaal bij een patiënt te verhelpen. De elektronische tegenhanger werkt in sommige gevallen echter beter. Langzaam wint deze techniek terrein zoals bij behandelingen voor het syndroom van Tourette, epilepsie en oorsuizen. Elektroceutica, een medische toepassing van bio-elektronica. Klein, flexibel en intelligent. Artikel in EngineersOnline.nl, over een presentatie van prof. dr. ir. Wouter Serdijn, hoogleraar bio-elektronica aan de Technische Unversiteit Delft.

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Slimme sensor die energie uit de lucht plukt, heeft eindeloos veel toepassingsmogelijkheden

Begin oktober gingen ze in het kader van een pilot het asfalt in: slimme sensoren die de temperatuur in het wegdek meten, zodat onder andere veel gerichter en efficiënter tegen gladheid kan worden gestrooid. De innovatie werd mede mogelijk gemaakt door de sectie Bioelectronics binnen de faculteit Elektrotechniek, Wiskunde en Informatica van de TU Delft die zich volgens hoogleraar Wouter Serdijn vooral bezig houdt met…de elektronische behandeling van aandoeningen in het menselijk lichaam.

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Maakt bio-elektronica medicijnen overbodig?

Artikel van ir. Jim Heirbaut in De Ingenieur, d. 9 april 2018, over dat sommige reumapatiënten minder last van ontstekingen in hun gewrichten hebben als er onschuldige stroompulsjes worden losgelaten op de zenuwbundel in hun hals. Met daarin een bijdrage van Wouter Serdijn, hoogleraar bioelektronica aan de TU Delft.

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How Master student Alberto contributes to impact

Master student Alberto Gancedo from Spain got the opportunity, via Delft University Fund, to start his Master’s programme Microelectronics at TU Delft in September 2017. Besides studying, he is also working on his own project ‘Amplitude-integrated EEG measurement system (aEEG)’. Alberto’s goal: to develop a small, portable and cheap monitoring device to detect babies unusual brain activity directly after birth.

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Slimme contactlenzen en andere medische gadgets in je lijf

Onderzoekers van de technische universiteit van Ulsan in Zuid-Korea zeggen een lens te hebben ontwikkeld die bloedsuikerwaarden uitmeet. Over deze lens en andere bio-elektronische medicijnen praten we met Wouter Serdijn. Hij is hoogleraar bio-elektronica aan de TU Delft. Item op NPO Radio 1, Nieuwsweekend, zaterdag 27 januari 2018.

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Grant for the development of smart cathethers & implants

Ronald Dekker, Vasiliki Giagka, Paul de Wit, Wouter Serdijn and Lina Sarro received a grant concerning the development of smart catheters and implants. The project is financed by ECSEL Innovation actions, Call 2017.

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Electrical Implants -- small devices with huge potential

Since the introduction of the pacemaker in 1958, much has changed in the world of electrical stimulation. Whereas the first electrical implants targeted muscles, the implants of today are flexible and focus mainly on the nerves in our body. The concept, however, remains unchanged: electrical implants give control back to the body. Vasiliki Giagka, Assistant Professor of Bioelectronics at TU Delft, talks about the past, present and future of her field of research.

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TU Delft "Female Fellowship" Tenure Track Academic Positions

All academic levels; apply before Jan 8, 2018.

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Denk de koffiezet aan

Elon Musk droomt hardop van telepathische communicatie en van een veel grotere geheugeninhoud. Het zijn ideeën die wetenschappers en hippies in de sixties al koesterden, maar die vandaag nog gul op scepticisme stoten. Artikel van Tomas Van Dijk, in de Belgische krant De Standaard, d. 4 augustus 2017. Met bijdragen van Dirk de Ridder (University of Otago, Nieuw-Zeeland) en Wouter Serdijn (TU Delft / Bioelectronics).

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Hebben wij het eeuwige leven?

Artikel in De Telegraaf, d. 29 juli 2017, van Wouter van Bergen, over transhumanisme en de rol van technologie. Met daarin een interview met Wouter Serdijn (TU Delft/Bioelectronics).

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Samprajani Rout's ISCAS 2017 paper among top papers of the conference

ISCAS 2017 paper No. 1849, entitled “Structured Electronic Design of High-Pass ΣΔ Converters and Their Application to Cardiac Signal Acquisition” has been selected as one of the top contributions to the conference and an extended version of the paper has been invited for the TBioCAS Special Issue on ISCAS 2017. Authors of the paper are Samprajani Rout and Wouter Serdijn (Section Bioelectronics)

Abstract of the paper:

Achieving an accurate sub-Hz high-pass (HP) cutoff frequency and simultaneously a high accuracy of the transfer function is a challenge in the implementation of analog-to-digital converters for biomedical ExG signals. A structured electronic design approach based on state-space forms is proposed to develop HP modulators targeting high accuracy of the HP cutoff frequency and good linearity. Intermediate transfer functions are mathematically evaluated to compare the proposed HP Sigma-Delta topologies with respect to dynamic range. Finally, to illustrate the design method, an orthonormal HP Sigma-Delta modulator is designed to be implemented in 0.18 um technology which achieves a linearity of 12 bits.


NWO Take-Off Grant (Phase 1) for Ide Swager and Menno Gravemaker (Momo Medical) and Wouter Serdijn (Section Bioelectronics)

Pressure ulcer wounds are a global problem in healthcare institutions, still. These wounds cause a lot of pain and discomfort for the patient, a high workload for the caregivers and cost a lot of money, in the EU alone already more than 15 billion Euros each year. TU Delft spin-off Momo Medical has developed a smart sensor bed sensor that solves this problem.

In this project, the following steps are taken to test the smart bed sensor in practice, in the Living Lab of the Reinier de Graaf Hospital. In addition, further commercial development is done by approaching more potential customers and understanding the cost structure of the product better when scaling up.

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Vasiliki Giagka elected member of the IEEE Biomedical and Life Science Circuits and SystemsTechnical Committee

At its annual meeting during the International Symposium on Circuits and Systems, Vasiliki Giagka (Section Bioelectronics) was elected member of the IEEE Biomedical and Lifescience Circuits and Systems Technical Committee.

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ABN Amro gaat betalen met je ring mogelijk maken

ABN Amro claimt de eerste bank ter wereld te zijn die het mogelijk maakt om met een ring te betalen in plaats van met een pinpas. De bank experimenteert daar momenteel mee met een selecte groep van klanten. Hoeveel mensen met de ring willen betalen, is nog maar de vraag. Volgens hoogleraar bio-elektronica Wouter Serdijn hangt dat ook af van wat de ring nog meer voor functies krijgt. Item van de NOS, ook verschenen bij Finanzen en PowNed, d. 22 juni 2017.

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NWO Demonstrator Grant awarded to Wouter Serdijn (Bioelectronics) and Cees-Jeroen Bes (in-Holland)

We recently developed a radically new technique, coined "additive companding", which solves important technological limitations of current neural recording systems. The technology has been patented, tested in the lab as proof of concept and is now ready to be developed further into a prototype. The foreseen prototype will allow for continuous and complete monitoring of neural activity, offers better performance and consumes drastically less volume (<400 µm x 400 µm x 400 µm) and energy (<<1 mW) than neural monitoring systems that currently exist or are under development. Clinically, the continuous and complete neural monitoring will offer new insights into the exact workings of nerve and brain tissue and it becomes possible to take the first step into the development of active medical implants that adjust themselves to the therapeutical needs of the patient without subjective measures. This, ultimately, enhances the health-related quality of life of patients with nerve and/or brain disorders and allows for a better treatment of a larger variety of nerve and brain disorders.


In de Zweedse trein kun je inchecken met een onderhuidse chip

Alleen uw hand even omhooghouden, waarna de treinconducteur die met zijn smartphone aanraakt en 'bliep': u bent ingecheckt. In Nederland is dit nog toekomstmuziek, maar in Zweden beleven treinreizigers momenteel de wereldwijde primeur in het openbaar vervoer: inchecken met een onder de huid aangebrachte microchip. Artikel in De Volkskrant en in De Morgen, d. 17 juni 2017, met een bijdrage van Wouter Serdijn

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This is how we will become bionic super humans

Tech companies want to fix spinal cord injuries and make enhanced super humans that communicate through telepathy, or so Prof. Wouter Serdijn heard at a meeting this spring in Washington. There are some snags though.

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Alberto Gancedo-Reguilon awarded grant from the Delft University Fund and Electrical Engineering Alumni

A year ago our faculty took part in a pilot mailing of the University Fund to acquire funding by alumni. The result was positive with a result of €5000 to fund a student project at EEMCS.

The selected project for this funding is of a Spanish Bachelor student called Alberto Gancedo, who did an internship at our Micro-Electronics department (Section Bioelectronics) and at HealthTech BV. He is working on an aEEG Measurement System. His goal is to create a portable and affordable tool to track brain development of neonatal babies. These tools are already available, in developed countries. However, these are big and expensive devices. Alberto's tool can be used in any hospital, instead of just a few, and also in developing countries because of low production costs and its small size. The prototype is ready and Alberto will return to Delft in September to start his Masters' degree and to continue with this project.

About the University Fund

The University Fund would like to give young talent the chance to shine. Therefore they hand out funding for e.g. internships abroad, study trips and participation at international conferences. Excellent achievements are rewarded too with funding and recognition.


Acting on the potential of action potentials: will bioelectronic medicines be the next biologics?

Article by Emma Dorey in The Pharmaceutical Journal, 9 DEC 2016. In there, an interview with Wouter Serdijn

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Universiteit van Nederland: Hoe kun je een dove laten horen en een blinde laten zien?

Hoe kun je een dove laten horen en een blinde laten zien?

Door prof. dr. ir. Wouter Serdijn

Doven weer laten horen en blinden weer laten zien: het lijkt misschien een godswonder, maar in principe heb je genoeg aan een superslimme chip. Hoe dat precies werkt weet elektronicus Wouter Serdijn (TU Delft) als geen ander. Laat je rondleiden in een wereld die zich op de vierkante millimeter afspeelt en ervaar zelf hoe het klinkt om met een chip te horen.

prof. dr. ir. Wouter Serdijn

Je lijf aansturen met behulp van bio-elektronica, dat is de tak van sport van prof. dr. Wouter Serdijn (TU Delft). Met behulp van implanteerbare chips in je lijf kun je je brein een handje helpen om losse elektronische eindjes weer goed aan elkaar te knopen. Het gevolg? Patiënten beter laten zien, horen of minder laten trillen (bij bijvoorbeeld Parkinsonpatienten).

De Universiteit van Nederland

Uitgezonden op 14 november 2016, om 20:30 uur. De Universiteit van Nederland is te bekijken via YouTube, NU.nl, Volkskrant.nl, Ziggo TV en sinds kort aan boord van alle KLM-vliegtuigen. De stichting wordt gesteund door 13 Nederlandse universiteiten, Ziggo, Deloitte, DELA en Shell.

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Vacancy: Team manager for Electrical Engineering Education (EEE)

The Faculty of EEMCS is creating a special team to fully focus on teaching using our unique and innovative ‘Delft method’. This method integrates practical and theoretical electrical engineering education and trains students to be hands-on, theoretically versed electrical engineers ready for a future career in science or industry.

We are looking for a team manager specialising in Electrical Engineering Education (EEE) who will be both a group leader and a teacher in his/her capacity as the role model of EE Education.

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Vacancy: Assistant/Associate Professor of Bioelectronics

Department/faculty: Electrical Engineering, Mathematics and Computer Science Level: PhD degree Working hours: 38 hours per week Contract: Tenure track with possibilities for advancement Salary: €3400 to €6299 per month gross

Electrical Engineering, Mathematics and Computer Science

The Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) is known worldwide for its high academic quality and the social relevance of its research programmes. The faculty's excellent facilities accentuate its international position in teaching and research. Within this interdisciplinary and international setting the faculty employs more than 1100 employees, including about 400 graduate students and about 2100 students. Together they work on a broad range of technical innovations in the fields of sustainable energy, telecommunications, microelectronics, embedded systems, computer and software engineering, interactive multimedia and applied mathematics. EEMCS: Your Connection to the Future.

The Department of Microelectronics has a strong interdisciplinary research and education programme in the areas of 1. health and well-being 2. next generation wireless and sensing technology and 3. safety and security. With 11 IEEE Fellows among the staff, an excellent microfabrication infrastructure, electrical and physical characterisation facilities, and a strong international academic and industrial network, the department provides high-level expertise in each of these areas throughout the entire system chain.

The Bioelectronics section is a relatively new section that has been created to address coherently the challenges we face in developing wearable, injectable and implantable medical devices. This group conducts research, education and valorisation in the fields of ultra low-power analog and mixed-signal circuits and systems for active wearable, implantable and injectable biomedical microsystems.

Job description

The Bioelectronics group is offering a tenure-track position at the Assistant or Associate Professor level in the field of biomedical circuits and systems. You will further develop existing research topics, such as analog and mixed-mode circuits and systems for wearable and implantable medical devices and create new topics, which may include electroceuticals. You will be involved in teaching at the BSc and MSc levels in the TU Delft's Electrical Engineering and Biomedical Engineering programmes. Collaborative initiatives are strongly encouraged. You are expected to write research proposals for national and international funding organisations. This is a tenure-track position for a period of five years with the possibility of a permanent faculty position at the end of the contract, subject to mutual agreement.

A Tenure Track, a process leading up to a permanent appointment with the prospect of becoming an Associate or Full Professor, offers young, talented academics a clear and attractive career path. During the Tenure Track, you will have the opportunity to develop into an internationally acknowledged and recognised academic. We offer a structured career and personal development programme designed to offer individual academics as much support as possible. For more information about the Tenure Track and the personal development programme, please visit www.tudelft.nl/tenuretrack.

Requirements

You must have a PhD degree in the field of biomedical circuits and systems (BioCAS) and some years of experience as a post-doc or university professor. You have an excellent academic track record, reflected by peer-reviewed journal publications, conference contributions, and international research experience. An affinity for working on the interface with other disciplines (biomedical engineering, neuroscience, electrophysiology, etc.) and with clinicians and medical researchers is preferred. You should have a demonstrated ability to initiate and direct research projects and to obtain external funding. Experience in teaching and mentoring of students is required. A teaching qualification is recommended. Demonstrated ability in written and spoken English is required.

Conditions of employment

A tenure-track position is offered for six years. Based on performance indicators agreed upon at the start of the appointment, a decision will be made by the fifth year whether to offer you a permanent faculty position. The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children's Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. The TU Delft sets specific standards for the English competency of the teaching staff. The TU Delft offers training to improve English competency. Inspiring, excellent education is our central aim. If you have less than five years of experience and do not yet have your teaching certificate, we allow you up to three years to obtain this.

Information and application

For more information about this position, please contact Prof. Wouter Serdijn, e-mail: W.A.Serdijn@tudelft.nl. To apply, please provide a detailed CV, publication list, and a written statement on your research and teaching interests and vision along with a letter of application and the names and contact details of at least three references. Please e-mail your application by 1 December 2016 to L. M. Ophey, Hr-eemcs@tudelft.nl. When applying for this position, please refer to vacancy number EWI2016-38.

Enquiries from agencies are not appreciated.


Boek: Vonken in de meterkast (Eng: Sparks in the meter box)

De schokkende strijd tegen depressie, Parkinson en andere hersenziekten

Ons brein is een meterkast, een netwerk van kabels dat het lichaam van stroom voorziet. Soms ontstaat er kortsluiting - kabels slijten, stoppen slaan door - met hersenziekten als gevolg. Op dat moment kan elektriciteit uitkomst bieden. Depressie, Parkinson en chronische pijn; met een stroomstoot kunnen steeds meer mensen van hun klachten worden afgeholpen.

In Vonken in de meterkast laat Bart Lutters ons kennismaken met de fascinerende wereld van de neurostimulatie; van de allereerste vonk tot de nieuwste wetenschappelijke ontwikkelingen. Wie is er ooit op het idee gekomen om een patiënt onder stroom te zetten? Welke ziektes kunnen er met stroom behandeld worden? En wat doet zo'n stroomstoot eigenlijk met onze hersenen? Vonken in de meterkast gaat over elektrische vissen en op-afstand bestuurbare stieren, robotarmen en gereanimeerde ledematen, maar vooral over hoe stroom ons al duizenden jaren beter maakt.

bart_luttersBart Lutters is zijn artsenopleiding aan het afronden (Selective Utrecht Medical Master) en wordt gefascineerd door alles wat met de hersenen te maken heeft. Hij heeft diverse prijzen gewonnen voor zijn onderzoek naar epilepsie en schrijft regelmatig over de geschiedenis van de geneeskunde in onder andere Brain, het toonaangevende wetenschappelijke tijdschrift op het gebied van de neurowetenschappen.

Vonken in de meterkast is vanaf 14 oktober verkrijgbaar in de betere boekhandel, ook online te bestellen via Bol.com.

Wouter Serdijn (hoogleraar bioelektronica aan de TU Delft) heeft middels interviews aan de inhoud van dit boek bijgedragen.


Wouter Serdijn on Dutch radio station Radio 1

In the late evening show "Met het Oog op Morgen" of August 2, Wouter Serdijn comments on the future developments of Bioelectronic Medicine

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New Book: Analog IC Design Techniques for Nanopower Biomedical Signal Processing

Description:

As the requirements for low power consumption and very small physical dimensions in portable, wearable and implantable medical devices are calling for integrated circuit design techniques using MOSFETs operating in the subthreshold regime, this book first revisits some well-known circuit techniques that use CMOS devices biased in subthreshold in order to establish nanopower integrated circuit designs. Based on the these findings, this book shows the development of a class-AB current-mode sample-and-hold circuit with an order of magnitude improvement in its figure of merit compared to other state-of-the-art designs. Also, the concepts and design procedures of 1) single-branch filters 2) follower-integrator-based lowpass filters and 3) modular transconductance reduction techniques for very low frequency filters are presented. Finally, to serve the requirement of a very large signal swing in an energy-based action potential detector, a nanopower class-AB current-mode analog multiplier is designed to handle input current amplitudes of more than 10 times the bias current of the multiplier circuit. The invented filter circuits have been fabricated in a standard 0.18 µ CMOS process in order to verify our circuit concepts and design procedures. Their experimental results are reported.

 

Keywords:

Analog integrated circuit, Biomedical electronics, Bionic ear, Bio-potential, CMOS, Current-mode, Cochlear implant, ECG, Filter, Gm-C, Multiplier, Neural recording, Sample-and-hold, Signal processing, Subthreshold, Switched-current, Transconductance reduction, Transconductor, Weak inversion

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FCA & CNHi Award for Alessandro Urso

Alessandro Urso, PhD student Bioelectronics, received an award from Fiat Chrysler Automobiles (FCA) and CNH Industrial for his MSc thesis that has been awarded Summa Cum Laude. The award ceremony was held on the 31st of May in the headquarters of Fiat inTurin, Italy.

Alessandro, formerly MSc student of the University of Ferrara, Italy, did his MSc thesis project on the design of world's most energy efficient multi-channel neurostimulator IC and was supervised by Gianluca Setti (U. Ferrara) and Wouter Serdijn (TU Delft).

Currently, Alessandro is working towards his PhD degree in the Bioelectronics Section of TU Delft.

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OCW Course Analog Integrated Circuit Design largest number of page views in 2015

Analog Integrated Circuit Design (ET4252) is an introductory course in analog circuit synthesis for microelectronic designers.

Topics include: Review of analog design basics; linear and non-linear analog building blocks: harmonic oscillators, (static and dynamic) translinear circuits, wideband amplifiers, filters; physical layout for robust analog circuits; design of voltage sources ranging from simple voltage dividers to high-performance bandgaps, and current source implementations from a single resistor to high-quality references based on negative-feedback structures.

The course coordinator and teacher of the course is Wouter A. Serdijn.

The course can also be downloaded from iTunes University via: https://itunes.apple.com/us/itunes-u/analog-integrated-circuit/id491267057?mt=10

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How can you get a deaf person to hear and a blind person to see again?

Prof. Wouter Serdijn, head of the bioelectronics Department will give the lecture: 'Hoe kun je een dove weer laten horen en een blinde weer laten zien?' (How can you get a deaf person to hear and a blind person to see again?) for the Universiteit van Nederland. This lecture, lasting around 15 minutes, is part of a lecture series on the senses, in which a total of five leading scientists are taking part. The recordings will take place on Tuesday 31 May. Students and staff at TU Delft receive a 25% discount on the ticket price. The lectures will be in Dutch.

For information about tickets please visit the website from the Universiteit van Nederland


Vasso Giagka in Quadraad

This section features stories by two new members of EEMCS staff. This time they are Vasiliki Giagka and Johan Bosman.

Vasiliki GiagkaVasiliki Giagka
Is assistant professor in the Microelectronics department / Bioelectronics group.

Vasiliki Giagka (1984) was born in Athens. After studying Electronic and Computer Engineering at the Aristotle University of Thessaloniki, she completed her PhD at University College London in 2014. She has been living in Rotterdam since September. It will take her a while to get used to the Netherlands, far away from her friends in London. But she is happy with her bike, which gives her the freedom to go anywhere. Vasiliki Giagka joined the Microelectronics department in September 2015 as one of the three new tenure trackers. This quarter, she is teaching the courses Bioelectricity and Biomedical Engineering. Together with Prof Wouter Serdijn and Dr Reza Lotfi, she is developing a new course on Active Implantable Biomedical Microsystems.
Her research at TU Delft is still in its early stages. She is working on a European project proposal with a large number of partners. It’s an exciting process. In London, she was part of the European ?Neuwalk? project, aimed at repairing the body’s motor functions after serious cases of paraplegia from spinal cord injury. Giagka: ?As part of ?Neuwalk?, I focused on developing low-power flexible implants to repair the motor system.? In her free time, Giagka likes practising yoga and learning new languages. Giagka: ?Language learning expands the mind. Language also reveals a lot about a country’s culture. For example, in Greece, they do not have a good word for the term ?deadline?.? In addition to Greek and English, she has also studied some German, French, Spanish and, now Dutch. Giagka: ?I am currently midway through level A2.?

V.Giagka@tudelft.nl

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Wouter Serdijn receives the 2016 IEEE Circuits and Systems Meritorious Service Award

IEEE CAS award for Wouter Serdijn

Wouter Serdijn (Section Bioelectronics) received from the IEEE Circuits and System Society (CAS) the Meritorious Service Award. This award honors the individual with exceptional long-term service and dedication to the interest of the CAS Society. Wouter Serdijn was awarded for his extraordinary leadership in improving technical quality and organization of IEEE CASS Flagship Conferences, such as the IEEE International Symposium on Circuits and Systems and the IEEE Biomedical Circuits and Systems Conference, and Transactions, in particular the IEEE Transactions on Circuits and Systems.

The award ceremony will be next week in Montreal during the annual ISCAS conference.


New book: Design of Efficient and Safe Neural Stimulators - A Multidisciplinary Approach

About this book:

This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson?s, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples.

About the authors:

Marijn N. van Dongen was born in Pijnacker, The Netherlands, in 1984. He received the M.Sc. and Ph.D. degrees in electrical engineering from the Delft University of Technology, Delft, The Netherlands, in 2010 and 2015, respectively. His research interests include the design of neural stimulator output circuits as well as the modeling of the electrophysiological and electrochemical processes during electrical stimulation. Currently he is working for NXP Semiconductors, Nijmegen, The Netherlands. Dr. van Dongen served as the Financial Chair of the IEEE BioCAS2013 Conference.

Wouter A. Serdijn (M'98, SM'08, F'11) was born in Zoetermeer ('Sweet Lake City'), the Netherlands, in 1966. He received the M.Sc. (cum laude) and Ph.D. degrees from Delft University of Technology, Delft, The Netherlands, in 1989 and 1994, respectively. Currently, he is full professor of bioelectronics at Delft University of Technology, where he heads the Section Bioelectronics. His research interests include low-voltage, ultra-low-power and ultra wideband integrated circuits and systems for biosignal conditioning and detection, neuroprosthetics, transcutaneous wireless communication, power management and energy harvesting as applied in, e.g., hearing instruments, cardiac pacemakers, cochlear implants, neurostimulators, portable, wearable, implantable and injectable medical devices and electroceuticals.
He is co-editor and co-author of 9 books, 8 book chapters and more than 300 scientific publications and presentations. He teaches Circuit Theory, Analog Signal Processing, Micropower Analog IC Design and Bioelectronics. He received the Electrical Engineering Best Teacher Award in 2001, 2004 and 2015. Wouter A. Serdijn is an IEEE Fellow, an IEEE Distuingished Lecturer and a Mentor of the IEEE.

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New project "Earlier recognition of cardiovascular diseases" approved

Atrial fibrillation (AF) is a progressive disease and associated with severe complications such as stroke. Early treatment of AF is of paramount importance as it inhibits disease progression from the treatable (recurrent intermittent) to the untreatable (permanent) stage of AF. However, early treatment is seriously hampered by lack of accurate diagnostic instruments to recognize patients who will develop new onset AF or progress to a severer form of the disease.

The goal of this project is to develop age and gender based, bio-electrical diagnostic tests, the invasive and non-invasive AF Fingerprint, which consists of electrical atrial signal profiles and levels of atrial specific tissue/blood biomarkers. In daily clinical practice, this novel diagnostic instrument can be used for early recognition or progression of AF by determination of stage of the electropathology. As such, AF Fingerprinting enables optimal AF treatment, thereby improving patient?s outcome.

The project is a collaboration between Erasmus University (Dept. Cardiology), VU Medical Center (Dept. Physiology), and TU Delft (Sections CAS and Bioelectronics), and will fund 4 PhD students.


2016 IEEE Biomedical Circuits and Systems Conference (BioCAS 2016), Oct. 17-19 | Shanghai, China

IEEE BioCAS is a premier international forum for researchers and engineers to present their state-of-the-art multidisciplinary research and development activities at the frontiers of medicine, life sciences, and engineering. The conference will enable members of circuits and systems communities to broaden their knowledge in emerging areas of research at the interface of the life sciences and engineering.

BioCAS 2016 comprises invited talks on cutting-edge development, insightful tutorials in engineering and medicine, demonstrations, and technical sessions. The three-day program of BioCAS 2016 is multidisciplinary in topics including but not limited to:

  • Bio-inspired and Neuromorphic Circuits and Systems
  • Bio-medical Sensors and Interfacing Circuits
  • Biomedical Imaging Technologies & Image Processing
  • Electronics for Brain Science
  • Genomics and Systems Biology
  • Implantable and Wearable Devices and Systems
  • Internet of Things (IoT) for Healthcare
  • Innovative Circuits for Medical Applications
  • Lab-on-Chip/BioMEMS/Point-of care Devices
  • Medical Information Systems and Bioinformatics
  • Rehabilitation and Assistive Technologies
  • Signal Processing Systems for Bio-medical Applications
  • Therapeutic Devices and Closed-loop Systems
  • Wireless and Energy Harvesting/Scavenging Technology

Call for Papers

The complete 4-page paper (in standard IEEE double-column format), including the title, authors' names, aliations and e-mail addresses, as well as a short abstract and an optional demonstration video link (3 minutes max) are requested during submission. Papers must be submitted electronically in PDF format through http://www.biocas2016.org.

Important dates:

  • Special Session Proposal Due: June 5, 2016
  • Paper Submission Due: June 15, 2016
  • Demonstration Proposal Due: July 31, 2016
  • Author Notication Date: August 31, 2016
  • Author Registration Date: September 15, 2016
  • Conference Dates: October 17-19, 2016
  • Post Conference Workshop Dates: October 20-21, 2016

Highlights:

Selected BioCAS2016 papers will be published in the IEEE Transactions on Biomedical Circuits and Systems Special Issue.

BrainCAS, a 2-day post conference workshop, will be held in Hangzhou (a beautiful city near Shanghai) from Oct. 20-21, 2016. More details of BrainCAS will be available in BioCAS2016 website soon.


New book by Amir Zjajo: Brain-Machine Interface

low-power analog front-end circuits for brain signal conditioning and quantization and digital back-end circuits for signal detection

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Happy 2016!

Here are some pictures of the New Year Reception of the Microelectronics department

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Summa Cum Laude for Alessandro Urso

Alessandro received this honorary distiction from the University of Ferrara, Italy. His supervisors were Gianluca Setti and Wouter Serdijn. Alessandro will continue his studies as a PhD student at Delft University of Technology, working on wireless enerfy harvesting for autonomous wireless sensor nodes.


How do you become Best Lecturer of TU Delft?

On 26th November, the Best Lecturer of the year 2015 was chosen. 8 nominees, one from each faculty, competed for the prize. But how do you ?become? lecturer of the year of lecturer or your faculty? How does the lecturer of the year differentiates him or herself from the other lecturers? Is the interaction with the students different and what is the ?Golden tip??

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TU Delft Female Fellowship Tenure Track Openings

Academic openings at all professor levels

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Optogenetics: lighting the way to the future

The brain is the mystery of the human body. Neurons, as primary units of the nervous system, are joined together into a complicated biological interconnected network. A conventional method to manipulate the neural performance within this network is to use drugs that alter the chemical balance of the brain. However, a crucial aspect of the nervous systems is the electrical signalling between the neurons. Bioelectronics has advanced the neural modulation techniques beyond the conventional methods by developing electrical brain stimulation tools. Electrical brain stimulation is truly beneficial to understand the mechanism underlying neural behaviour, and develop novel therapeutic methods. Optogenetics is another breakthrough method in neural stimulation techniques, which has opened up entirely new avenues of research opportunities in the fields of neuroscience and bioelectronics. In this article, the basic principles of optogenetics and a state-of-the-art bioelectronics application for the treatment of epilepsy are described.

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ISCAS 2015 Keynote Presentation Ronald Dekker online

Ronald Dekker's Keynote: ?From Chips for the Living to Living Chips?

Micro-fabricated devices are finding their way to the frontend of medical equipment, where they are the interface between body, or in general living tissue, and machine. They enable better and cheaper diagnostic equipment, they add ?eyes and ears? to minimally invasive instruments such as laparoscopic instruments and catheters, they allow for un-obtrusive monitoring of body functions, they add functionality to implants, and they enable the development of better and personalized medicines. Despite their great promise it has been proven difficult to bring these devices out of the laboratory phase into production. One of the reasons is the lack of a suitable fabrication infrastructure. Much more than standard CMOS or MEMS devices, these medical devices rely on the processing of novel materials, especially polymers, in combination with advanced molding, micro-fluidics, and assembly technologies. At the same time these devices have to be fabricated under strict quality control conditions in a certified production environment.

In the recently granted ECSEL project ?InForMed? a supply chain for the pilot fabrication of these medical devices is organized, which brings together key European technology partners in an integrated infrastructure linking research to pilot and high volume production. The pilot line is hosted by Philips Innovation Services, and open to third party users.

Speaker Biography:

Ronald Dekker received his MSc in Electrical Engineering from the Technical University of Eindhoven and his PhD from the Technical University of Delft. He joined Philips Research in 1988 where he worked on the development of RF technologies for mobile communication. Since 2000 his focus shifted to the integration of complex electronic sensor functionality on the tip of the smallest minimal invasive instruments such as catheters and guide-wires. In 2007 he was appointed part time professor at the Technical University of Delft with a focus on Organ-on-Chip devices. He published in leading Journals and conferences and holds in excess of 50 patents.

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Wouter Serdijn on BNR Eye Openers

Listen here for the recording.

The broadcast has been repeated on: Friday, July 10, at 19:30 hrs, Saturday, July 11 at 9:00 and 15:30 hrs and Sunday, July 12, at 9:00 and 18:30 hrs; also via the App.

Host of Eyeopeners is Marijke Roskam.

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Wouter Serdijn Teacher of the Year 2014-2015

Rationale behind his award is that Wouter Serdijn is "a good lecturer, is involved with his students and conducts important research himself".

This is actually not the first time that Wouter got elected Teacher of the Year. In 2001 and 2004 he already won the cup. This, however, is the first time that he also has been elected Teacher of the Year for the whole faculty, a new distinction that was established in 2012.

Wouter Serdijn is professor in Biomedical Circuits and Systems and heads the Bioelectronics Section at EEMCS.

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ISCAS 2015 in Lisbon a big success

Franco Maloberti, President Elect of the IEEE Circuits and Systems Society mentioned as highlights of the conference:

- The excellent location and organization: "Let me congratulate the General Chairs, Technical Program Chairs and organizing staff with the perfect flow of things and outstanding service to our community";

- Good participation to sessions and good quality of papers;

- Beneficial socialization during coffee breaks and social events; and

- Very successful side events (Special events, John Choma Commemoration, PhD Gold Young Professional, Women in CAS, Conference Leadership).


Wouter Serdijn No. 12 in Vrij Nederland's Nerd 101

Wouter Serdijn (head of the Bioelectronics Section at Delft University of Technology) ended up No. 2 in the category "wearables". To him, wearables are just an intermediate station in the journey into implantables. A special kind of implantables, called "electroceuticals" will complement traditional pharmaceuticals and will help treating patients that suffer from neurological disorders better. On June 10, an item about him and his work appeared in Vrij Nederland. Together with 10 other nerds he ended no. 12 in VN's Nerd 101, the shortlist of the 101 most interesting technologists, inventors and botchers of the Netherlands.

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Leo de Vreede most entrepreneurial TU Delft scientist

During the annual YES!Delft Network Event on 18 May, the Delft Entrepreneurial Scientist Awards (DESA) were presented for researchers who encourage entrepreneurship. Dr Leo de Vreede of the Department of Microelectronics (EEMCS) was named the most entrepreneurial scientist at TU Delft.

Leo de Vreede is an associate professor at the Electronics Research Laboratory. In 2010, he founded the company Anteverta-mw. Building on the knowledge from his PhD research, the company developed a device that drastically accelerates and improves continuity testing of base stations for mobile telephony. As a result, data transfer is improved and energy consumption reduced. The TU Delft spin-off was taken over earlier this year by the American company Maury Microwave Corporation.

Jury chairman and President of the Executive Board Dirk Jan van den Berg praised De Vreede for his involvement with many spin-off companies and patent requests. The scientists received �valorisation bonuses� of �15,000 and �5,000 respectively.


Presentation on electroceuticals: getting better with electricity

On May 6, 2015, Collegerama of TU Delft made video recordings of the lecture Wouter Serdijn gave on Electroceuticals.

Electroceuticals are the electronic counterparts of pharmaceuticals and are miniature electronic devices that interact with the body in an electrical fashion.

In this talk Wouter Serdijn discusses: - neurostimulation and the need to make neurostimulators smaller, more power efficient and more intelligent; - optogenetic neuromodulation and the need to make this new neuromodulation modality operate in a closed-loop fashion; - neurosensing devices to make neurostimulators intelligent and thereby adjust themselves to the therapeutical needs of the patient; - autonomous wireless sensor nodes that can measure temperature or the electrocardiogram without the need for a battery; - an outlook into the future of electroceuticals with the promise to treat a larger variety of neurological and brain disorders better. Click here to start watching the video and slides: https://collegerama.tudelft.nl/Mediasite/Play/cc7888beb88349c1a60c1414476b577a1d?catalog=528e5b24-a2fc-4def-870e-65bd84b28a8c

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Delftse promovendus ontwikkelt volgende generatie neurostimulator

Marijn van Dongen is vandaag aan de TU Delft gepromoveerd op het chipontwerp voor een neurostimulator die klein genoeg is om in de schedel aan te brengen, dicht bij de plek waar gestimuleerd moet worden. Normaal gesproken worden neurostimulatoren uitgevoerd in de vormfactor van een pacemaker; vanwege hun afmetingen worden ze in de borst ge?mplanteerd en via onderhuidse draden verbonden met de elektroden in het hersenweefsel. Deze leads zijn echter gevoelig voor slijtage.

De batterij is echter een beperkende factor bij het miniaturiseren van deze apparaten. Daarom zocht de promovendus naar alternatieve stimulatiescenario?s die minder energie gebruiken. Uit simulaties en in vitro-proeven bleek het gebruik van hoogfrequente series stroompulsjes een veelbelovende aanpak. Dit soort pulsjes kunnen op een energie-effici?nte manier worden opgewekt dankzij het principe van een geschakelde voeding; een prototype van de neurostimulator was een factor drie zuiniger dan de huidige stimulatoren. Bovendien kan de pulsgebaseerde aanpak verschillende doelen tegelijkertijd activeren en daarmee de doelmatigheid van de behandeling verhogen.

De onderzoekers denken dat kleinere stimulatoren uiteindelijk breder ingezet kunnen worden. Op het moment wordt neurostimulatie vaak nog gezien als laatste redmiddel bij chronische aandoeningen als Parkinson, depressie, pijn en tinnitus. Er is echter nog een scala aan andere mogelijke toepassingen, zoals zoals epilepsie, verslavingen, migraine en dementie.

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Congratulations to Prof. dr. Sarro with her royal honour

Professor Lina Sarro, professor of micro-electronics at the Faculty of Electrical Engineering, Mathematics and Computer Science, has been made a Knight in the Order of the Netherlands Lion, in The Hague.

She received the award because of her original research that resulted in a large scientific body of work and because of her in-depth involvement with her many students. Her pioneering work in the 1980s in the field of infrared sensors led to international acclaim. Since 1987, she has been in charge of research into micro and nanosystems (MEMS and NEMS) at the Else Kooi Lab, which was known previously as the Dimes Institute for Microsystems and Nanoelectronics.

Professor Sarro has published more than 200 articles in scientific journals and has received awards for her work on several occasions. In 2004, she received the Eurosensors Fellow Award, in 2007 the AISEM Career Award, and in 2012 the IEEE Sensors Council Meritorious Award. She is also a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) and a fellow of the Institute of Electrical and Electronics Engineers. She has been praised on account of both her scientific work and her unfailing commitment to providing teaching of a high standard.

To her students, from both inside and outside the Netherlands, she is a figurehead. This applies perhaps in particular to female students and academics. In 2005, Professor Sarro became the first female to join the TU Delft Council of Professors. She is dedicated to emphasising the role of female scientists, in the conviction that it is a waste to use only half of our scientific assets. Her outstanding scientific reputation ensures that her voice is heard in this, and in other issues.


Medical Delta speeds up development of cochlear implants

Uit ?De Audiciens?, februari 2015: ?CI?s (cochleaire implantaten, Red.) volop in ontwikkeling.

Het is een traditie, de refereeravond van KNO/Centrum voor Audiologie en Hoorimplantaten (CAHIL) in het LUMC op de tweede donderdag van het jaar.

Ook op 8 januari 2015 zit de collegezaal weer vol. Het is dan ook een bijeenkomst waar een aantal disciplines uit de hoorbranche samenkomen. KNO-artsen, audiologen, akoepedisten, audiciens, fabrikanten en anderen luisteren naar voordrachten die inzicht geven in nieuwe ontwikkelingen op audiologisch gebied.

De avond wordt geopend door prof. dr. ir. J.H.M. Frijns, hoofd CAHIL. (?) In het kader van de Medical Delta (een samenwerkingsverband tussen het Erasmus MC in Rotterdam, de TU Delft en het LUMC in Leiden voor de ontwikkeling van medische technologie) is er een presentatie van Johan de Vos die als arts-onderzoeker KNO onderzoek verricht naar nieuwe technologie voor cochleaire implantaten. Onder begeleiding van Wouter Serdijn en Paddy French hebben drie promovendi van de TU een meetversterker (Cees Jeroen Bes), een elektrode ontwerp (Nishant Lawant) en een stimulatorchip (Wannaya Ngamkham) ontwikkeld. Deze technologie wordt onder leiding van Johan Frijns en Jeroen Briaire in het LUMC geimplanteerd en getest door Johan de Vos. Tevens ontwikkelt het LUMC nieuwe meetmethodes voor het terugmeten van de respons van de gehoorzenuw (Dick Biesheuvel).?

Lees meer hier: http://bioelectronics.tudelft.nl/~wout/documents/news/lumc_refereeravond_20150108.pdf

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10 years of BioCAS, the Biomedical Circuits and Systems Symposium


Taco Kindt, Cees-Jeroen Bes and Hossein Tajeddin win 2nd prize in Proof-It Award contest

During the Proof-It Awards session of Medical Delta at the Border Sessions, Nov. 12 in The Hague, The Netherlands, the team of FetalStar (Taco Kindt, Cees Jeroen Bes (Section Bioelectronics) and Hossein Tajeddin (HealtTech)) won the 2nd prize. Congratulations! The 2nd prize will allow them to continue working on their revolutionary fetal ECG monitoring concept and bring it closer to a prototype.


Wouter Serdijn at the Border Sessions 2014; the international technology festival

As part of the Crossing Borders Festival in The Hague, Wouter Serdijn will give a talk on the Future of Implantable Technology at the Border Sessions, Nov. 12, 13:00 hrs.

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Vacancy: assistant professor in bioelectronics

In the Section Bioelectronics of Delft University of Technology, there is an opening for a tenure track position in bioelectronics.

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Cees-Jeroen Bes and Wouter Serdijn on Dutch TV station RTL4

On Sept. 25, the RTL4 TV program "Editie NL" made a news item on chipping humans. Cees-Jeroen Bes and Wouter Serdijn offered a glimpse into the future.

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Chapter on RF energy harvesting published

Andre Mansano, Mark Stoopman and Wouter Serdijn contributed a chapter on RF energy harvesting to an Elsevier book, entitled "Wearable Sensors: Fundamentals, Implementation and Applications", which appeared this month.


Both BioCAS 2014 papers have been accepted

The paper by Andre Mansano and Yongjia Li and the paper by Marijn van Dongen et al. have been accepted for BioCAS 2014. Congratulations!


An electronic eye on the children

Article in Vrij Nederland (in Dutch), d. Aug. 2, by Marjolein van Trigt about Child Tracking. In there, Wouter Serdijn explains the possibilities, impossibilities and implications of an implantable RFID child tracker. Lees meer op: http://www.vn.nl/Archief/Samenleving/Artikel-Samenleving/Een-elektronisch-oogje-op-de-kinderen.htm#

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Efficacy of high frequency switched-mode stimulation in activating Purkinje cells; article published

We pre-published an important paper on a new neurostimulation paradigm on arXiv. The paper can be found here: http://arxiv.org/pdf/1406.7185v1.pdf.

Abstract: This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well as the axon membrane, it is first shown that switched-mode stimulation depolarizes the cell membrane in a similar way as classical constant amplitude stimulation. These findings are subsequently verified using in vitro experiments in which the response of a Purkinje cell is measured due to a stimulation signal in the molecular layer of the cerebellum of a mouse. For this purpose a stimulator circuit is developed that is able to produce a monophasic high frequency switched-mode stimulation signal. The results confirm the modeling by showing that switched-mode stimulation is able to induce similar responses in the Purkinje cell as classical stimulation using a constant current source. This conclusion opens up possibilities for novel stimulation designs that can improve the performance of the stimulator circuitry. Care has to be taken to avoid losses in the system due to the higher operating frequency.

Authored by: M.N. van Dongen, F.E. Hoebeek, S.K.E. Koekkoek, C.I. De Zeeuw, W.A. Serdijn


BioCAS 2013 "one of the most successful editions"

9th IEEE BioCAS Advancing Healthcare Technology Conference

By Mohamad Sawan

The 9th IEEE BioCAS Advancing Healthcare Technology Conference was held in the Inntel Hotel, located at the river Meuse in the city centre of Rotterdam, the Netherlands from October 31th to November 2nd, 2013.

Nowadays, BioCAS illustrates a new wave of circuits and systems inspired by biology and healthcare, life sciences, physical sciences and engineering with application to medical problems. This BioCAS brought a strong collaboration between the CAS society and biotechnologies by facilitating interdisciplinary collaborations among scientists, engineers and medical researchers and practitioners to solve complex problems and innovating in rapidly growing area of research. The multidisciplinary approach of BioCAS 2013 enabled the CAS community to benefit from live demonstrations, tutorials, special and regular sessions, all covering a wide range of topics: biofeedback and electrical stimulation, bioinspired circuits and systems, biomedical imaging technologies and image processing, BioMEMs, biomedical instrumentations, biosensors, bioactuators, bio-signal processing, body area networks/body sensor networks, electronics for brain science and brain machine interfaces, implantable electronics, innovative circuits and systems for medical applications, lab-on-chip, medical information systems and wireless and energy harvesting /scavenging technology in medicine.

Figure 1

BioCAS 2013 was one of the most successful editions, three keynotes of world renowned experts were given: 1) Dr. Rudy Lauwereins, Vice President at IMEC, Belgium, explained how the combination of advanced process technology, heterogeneous integration, design methodology and application knowledge enables important breakthroughs in health care, diagnostics, monitoring and therapeutic cure. 2) Dr. Dirk de Ridder, Neurological Foundation professor of Neurosurgery at the University of Otago in New Zealand and Founder of the Brain Research center for Advanced, Innovative and Interdisciplinary Neuromodulation, addressed how engineers, basic and clinical neuroscientists and neurosurgeons should collaborate to develop the next generation of 3rd millennium neuromodulation devices. 3)Dr. John Parker of NICTA, the University of New South Wales and Saluda Medical Pty, all three in Australia, described how closed loop control of amplitude provides significant improvements in spinal cord stimulation to relieve pain.

The first day, the conference included four tutorials: 1) Dr. Shuenn-Yuh Lee presented Low Power Wireless ECG Acquisition and Cardiac Stimulation SOCs for Body Sensor Networks. 2) Drs. Trac D. Tran, Ralph Etienne-Cummings, Yuanming Suo, Jie Zhang, and Sang Chin presented how can compressed sensing help realize very-large scale embedded microelectrode arrays (VLSE-MEA). 3) Drs. Rahul Samant, Vivian Mushahwar, Ralph Etienne-Cummings, and Kevin Mazurek offered a tutorial about smart neural prostheses: design, development, and current state of neural prosthetic devices. 4) Dr. Ruud Vullers presented smart systems for healthcare and wellness.

Figure 2

Authors submitted 163 regular contributions (169 including those presented in special and demo sessions). These contributions are originated from 31 countries; 40% from Europe, 40% from Asia/Pacific and 20% from US and Canada. 93 high-quality papers were accepted and included in the final program, which was organized in 11 lecture and 2 poster sessions. In addition to the regular program, a special session on Implantable electronics for neural recording and stimulation was presented. BioCAS uses to pay particular attention on organizing great quality tutorials and posters, the later provided opportunity for lively discussions and productive exchange of ideas. The entire review process was carried out using ePapers, a professional on-line, web-based review system, involving 277 reviewers who have completed 600 reviews giving on average 3.6 reviews for each paper.

The final program provided ample opportunity for scientific discussions and time for site seeing and social interactions. Breaks, receptions, banquet, lunch times brought the scientific community closer. The standing rooms of the conference were a testament to the incredible quality of this year BioCAS. Detailed program and pictures of the conference, courtesy of the IEEE BioCAS local committee, are available at the IEEE BioCAS website (http://www.biocas2013.org).

The leadership of Dr. Wouter Serdijn, and Dr. Firat Yazicioglu, General co-chairs, as well as Dr. Gianluca Setti, and Tor Sverre (Bassen) Lande, Technical program co-chairs, guaranteed the success of the conference organization. These experienced colleagues were supported by several graduate students and the event was sponsored and supported by the IEEE, the IEEE Circuits and Systems Society (CASS), the IEEE Electronics in Medicine and Biology Society (EMBS), Delft University of Technology, IMEC Belgium, Advanced Bionics, the Biomedical Electronics Foundation and SystematIC.

Figure 3

The banquet of the conference took place on board of a modern and luxurious ship, where attendees enjoyed a unique dining experience and stunning scenery of the many architectural highlight of Rotterdam while the ship cruises around the city and Europe's largest port. In addition to an unforgettable Dinner, the committee delivered one of society best paper awards to one of the Authors who Selected BioCAS to receive his award.

The next BioCAS conference is sponsored by the ?cole Polytechnique F?d?ral de Lausanne (EPFL) and will be held on the shores of Lake Geneva, Lausanne, Switzerland on 22 to 24 October 2014.


Both ESSCIRC papers have been accepted

The papers of Yao Liu (on a phase-domain AGC for Bluetooth LE) and Andre Mansano (on an autonomous wireless temperature tag) have both been accepted for presentation at the upcoming European Solid-State Circuits Conference.


Wouter Serdijn representing IEEE in Brussels as a member of the IEEE ICT Working Group

Wouter Serdijn (Section Bioelectronics) has been elected and appointed by the IEEE Board of Directors to serve on the IEEE Working Group on ICT. Main objective of this working group is to increase IEEE?s presence and visibility on EU issues relating to ICT and provide the technical know-how to be integrated into EU policy. ?As IEEE is the world's largest professional association dedicated to advancing technological innovation and excellence for the benefit of humanity, operates transnationally and in a neutral fashion and has the technical competence in this domain, it is only natural that IEEE gives advice on ICT technological matters and acts as a sounding board?, Wouter says. In the IEEE Working Group on ICT, 14 members from various EU member states are active.


ISCAS 2014 a big success!

Wouter Serdijn (Section Bioelectronics) served as Technical Program Chair for this year's edition of ISCAS. Next year's edition will be held in Lisbon, Portugal. For this edition Wouter Serdijn will change hats and be General Chair.


Analog Integrated Circuit Design more than 10,000 page views in 2013

Open CourseWare course Analog Integrated Circuit Design (ET4252) received more than 10,000 page views in 2013 and is the No. 2 OCW course in Microelectronics

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The Bioelectronics weblog

Visit the weblog of the Section Bioelectronics at: http://bme.weblog.tudelft.nl/

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