MSc thesis project proposal
Biodegradable actuator for MECHANICAL STIMULATION of cells in Organs-on-Chip
Mechanical stimulation of cells for the growth of functional tissue is necessary, especially in the context of heart and muscle tissue. The advantage of a biodegradable substrate is that it disappears after a predefined period of time, leaving only the biological tissue for further biological use. The objective of this project is to develop biodegradable actuators for mechanical stimulation of cells in Organs-on-Chip platform.
This project will be performed in close collaboration with biologists from the Netherlands Organ-on-Chip Initiative (NOCI).
The student will perform the assignment at ECTM:
Duration: 9-12 months
Location: ECTM and EKL facilities at TU Delft
The expected activities
Synthesis and characterization of biodegradable material to be used in the actuators
Microfabrication and characterization of biodegradable wireless soft actuators for mechanical stimulation of cells in Organs-on-Chip platform
Development of a setup to control the actuators
In vitro study with cells as a proof a concept study
You are an ambitious student looking for a challenging thesis project on new materials and microfabrication of actuators for medical applications. You have a biomedical engineering, material science, mechanical or microelectronics background. Good communication skills in English and a pro-active attitude are expected.
dr. Clementine Boutry
Electronic Components, Technology and Materials Group
Department of Microelectronics
Last modified: 2023-12-05