dr. C.S. Vink

Laboratory Manager
Bioelectronics (BE), Department of Microelectronics

Expertise: Life Sciences (Stem Cell Biology, Regenerative Medicine, Developmental Biology), Biological Laboratory Management

Biography

Chris S. Vink received his BSc degree in Biology & Medical Laboratory Research (cum laude) from Rotterdam University of Applied Sciences (NL) in 2009, after completing his BSc thesis at The University of Oxford (UK). Straight after, he took on the role of head research technician at the Erasmus Stem Cell Institute (Erasmus MC, NL), where he actively performed blood stem cell (HSC) research and managed a biological laboratory. In 2014, he was responsible for relocating the laboratory to The University of Edinburgh (Scotland, UK), where he took on the role of laboratory manager. In addition to managing a lab, he continued as stem cell scientist focusing on the identification of novel molecules involved in HSC generation. In this role he also established and maintained several large-scale collaborative research projects (The University of Edinburgh, University of Cambridge, Erasmus MC). In 2022 he obtained his PhD degree from The University of Edinburgh. His research has resulted in 23 first-/co-authored articles of high significance in the stem cell field and three journal covers. In September 2023 he moved to the Bioelectronics Section (Dept. of Microelectronics) at TU Delft, to start working at the interface of biology and technology. Here, he will apply his >14 years of life sciences research and managerial experience to build, manage and perform research in a new state-of-the-art biological/cell laboratory that will facilitate the development of next-generation electroceuticals.

Publications

The (Intra-Aortic) Hematopoietic Cluster Cocktail: What is in the Mix?
Chris S. Vink; Elaine Dzierzak;
Experimental Hematology,
Volume 118, pp. 1--11, February 2023. DOI: 10.1016/j.exphem.2022.12.002
document
De Novo Hematopoietic (Stem) Cell Generation — A Differentiation or Stochastic Process?
Chris S. Vink; Anna Popravko; Elaine Dzierzak;
Current Opinion in Cell Biology,
Volume 85, Issue 102255, pp. 1--9, December 2023. DOI: 10.1016/j.ceb.2023.102255
document
Embryonic Origins of the Hematopoietic System: Hierarchies and Heterogeneity
Chris S. Vink; Samanta A. Mariani; Elaine Dzierzak;
HemaSphere,
Volume 6, Issue 6, pp. e737, June 2022. DOI: 10.1097/hs9.0000000000000737
document
PDGFRβ+ Cells Play a Dual Role as Hematopoietic Precursors and Niche Cells During Mouse Ontogeny
Diana Sá da Bandeira; Alastair M. Kilpatrick; Madalena Marques; Mario Gomez-Salazar; Telma Ventura; Zaniah N. Gonzalez; Dorota Stefancova; Fiona Rossi; Matthieu Vermeren; Chris S. Vink; Mariana Beltran; Neil C. Henderson; Bongnam Jung; Reinier van der Linden; Harmen J. G. van de Werken; Wilfred F.J. van IJcken; Christer Betsholtz; Stuart J. Forbes; Henar Cuervo; Mihaela Crisan;
Cell Reports,
Volume 40, Issue 3, pp. 111114, July 2022. DOI: 10.1016/j.celrep.2022.111114
document
Unexpected Redundancy of Gpr56 and Gpr97 During Hematopoietic Cell Development and Differentiation
Antonio Maglitto*; Samanta A. Mariani*; Emma de Pater; Carmen Rodriguez-Seoane; Chris S. Vink; Xianhua Piao; Mari-Liis Lukke; Elaine Dzierzak;
Blood Advances,
Volume 5, Issue 3, pp. 829--842, February 2021. DOI: 10.1182/bloodadvances.2020003693
document
CNS Macrophages Differentially Rely on an Intronic Csf1r Enhancer for Their Development
David A. D. Munro; Barry M. Bradford; Samanta A. Mariani; David W. Hampton; Chris S. Vink; Siddharthan Chandran; David A. Hume; Clare Pridans; Josef Priller;
Development,
Volume 147, Issue 23, pp. dev194449, December 2020. DOI: 10.1242/dev.194449
document
Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells
Chris S. Vink; Fernando J. Calero-Nieto; Xiaonan Wang; Antonio Maglitto; Samanta A. Mariani; Wajid Jawaid; Berthold Gottgens; Elaine Dzierzak;
Cell Reports,
Volume 31, Issue 6, pp. 107627, May 2020. DOI: 10.1016/j.celrep.2020.107627
document
Notch Ligand Dll4 Impairs Cell Recruitment to Aortic Clusters and Limits Blood Stem Cell Generation
Cristina Porcheri; Ohad Golan; Fernando J. Calero-Nieto; Roshana Thambyrajah; Cristina Ruiz-Herguido; Xiaonan Wang; Francesca Catto; Yolanda Guillen; Roshani Sinha; Jessica Gonzalez; Sarah J. Kinston; Samanta A. Mariani; Antonio Maglitto; Chris S. Vink; Elaine Dzierzak; Pierre Charbord; Bertie Gottgens; Lluis Espinosa; David Sprinzak; Anna Bigas;
The EMBO Journal,
Volume 39, Issue 8, March 2020. DOI: 10.15252/embj.2019104270
document
A Role for Macrophages in Hematopoiesis in the Embryonic Head
Zhuan Li; Samanta Mariani; Carmen Rodriguez-Seoane; Wenyan He; Xiaowei Ning; Bing Liu; Chris S. Vink; Elaine Dzierzak;
Blood,
October 2019. DOI: 10.1182/blood.2018881243
document
Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells
Samanta A. Mariani; Zhuan Li; Siobhan Rice; Carsten Krieg; Stamatina Fragkogianni; Mark Robinson; Chris S. Vink; Jeffrey W. Pollard; Elaine Dzierzak;
Immunity,
Volume 50, Issue 6, pp. 1439--1452.e5, June 2019. DOI: 10.1016/j.immuni.2019.05.003
document
Macrophages Restrict the Nephrogenic Field and Promote Endothelial Connections During Kidney Development
David AD Munro; Yishay Wineberg; Julia Tarnick; Chris S. Vink; Zhuan Li; Clare Pridans; Elaine Dzierzak; Tomer Kalisky; Peter Hohenstein; Jamie A. Davies;
eLife,
Volume 8, February 2019. DOI: 10.7554/elife.43271
document
In Vivo Single Cell Analysis Reveals Gata2 Dynamics in Cells Transitioning to Hematopoietic Fate
Christina Eich; Jochen Arlt; Chris S. Vink; Parham Solaimani Kartalaei; Polynikis Kaimakis; Samanta A. Mariani; Reinier van der Linden; Wiggert A. van Cappellen; Elaine Dzierzak;
Journal of Experimental Medicine,
Volume 215, Issue 1, pp. 233--248, December 2017. DOI: 10.1084/jem.20170807
document
Identification of Novel Regulators of Developmental Hematopoiesis Using Endoglin Regulatory Elements as Molecular Probes
Rabab Nasrallah; Eva M. Fast; Parham Solaimani; Kathy Knezevic; Alexia Eliades; Rahima Patel; Roshana Thambyrajah; Ashwin Unnikrishnan; Julie Thoms; Dominik Beck; Chris S. Vink; Aileen Smith; Jason Wong; Mairi Shepherd; David Kent; Rahul Roychoudhuri; Fabian Paul; Julia Klippert; Annette Hammes; Thomas Willnow; Bertie Gottgens; Elaine Dzierzak; Leonard I. Zon; George Lacaud; Valerie Kouskoff; John E. Pimanda;
Blood,
Volume 128, Issue 15, pp. 1928--1939, October 2016. DOI: 10.1182/blood-2016-02-697870
document
Hematopoietic (Stem) Cell Development - How Divergent Are the Roads Taken?
Mari-Liis Kauts; Chris S. Vink; Elaine Dzierzak;
FEBS Letters,
Volume 590, Issue 22, pp. 3975--3986, September 2016. DOI: 10.1002/1873-3468.12372
document
Subregional Localization and Characterization of Ly6aGFP-Expressing Hematopoietic Cells in the Mouse Embryonic Head
Zhuan Li; Chris S. Vink; Samanta A. Mariani; Elaine Dzierzak;
Developmental Biology,
Volume 416, Issue 1, pp. 34--41, August 2016. DOI: 10.1016/j.ydbio.2016.05.031
document
BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo
Mihaela Crisan; Parham Solaimani Kartalaei; Alex Neagu; Sofia Karkanpouna; Tomoko Yamada-Inagawa; Caterina Purini; Chris S. Vink; Reinier van der Linden; Wilfred van Ijcken; Susana M. Chuva de Sousa Lopes; Rui Monteiro; Christine Mummery; Elaine Dzierzak;
Stem Cell Reports,
Volume 6, Issue 3, pp. 383--395, March 2016. DOI: 10.1016/j.stemcr.2016.01.016
document
Functional and Molecular Characterization of Mouse Gata2-Independent Hematopoietic Progenitors
Polynikis Kaimakis*; Emma de Pater*; Christina Eich*; Parham Solaimani Kartalaei; Mari-Liis Kauts; Chris S. Vink; Reinier van der Linden; Martine Jaegle; Tomomasa Yokomizo; Dies Meijer; Elaine Dzierzak;
Blood,
Volume 127, Issue 11, pp. 1426--1437, March 2016. DOI: 10.1182/blood-2015-10-673749
document
BMP Signalling Differentially Regulates Distinct Haematopoietic Stem Cell Types
Mihaela Crisan; Parham Solaimani Kartalaei; Chris S. Vink; Tomoko Yamada-Inagawa; Karine Bollerot; Wilfred van IJcken; Reinier van der Linden; Susana M. Chuva de Sousa Lopes; Rui Monteiro; Christine Mummery; Elaine Dzierzak;
Nature Communications,
Volume 6, Issue 1, August 2015. DOI: 10.1038/ncomms9040
document
Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation
Parham Solaimani Kartalaei*; Tomoko Yamada-Inagawa*; Chris S. Vink; Emma de Pater; Reinier van der Linden; Jonathon Marks-Bluth; Anthon van der Sloot; Mirjam van den Hout; Tomomasa Yokomizo; M. Lucila van Schaick-Solerno; Ruud Delwel; John E. Pimanda; Wilfred F.J. van IJcken; Elaine Dzierzak;
Journal of Experimental Medicine,
Volume 212, Issue 1, pp. 93--106, December 2014. DOI: 10.1084/jem.20140767
document
HIF1-Alpha is a Regulator of Hematopoietic Progenitor and Stem Cell Development in Hypoxic Sites of the Mouse Embryo
Parisa Imanirad*; Parham Solaimani Kartalaei*; Mihaela Crisan*; Chris S. Vink; Tomoko Yamada-Inagawa; Emma de Pater; Dorota Kurek; Polynikis Kaimakis; Reiner van der Linden; Nancy Speck; Elaine Dzierzak;
Stem Cell Research,
Volume 12, Issue 1, pp. 24--35, January 2014. DOI: 10.1016/j.scr.2013.09.006
document
Gata2 is Required for HSC Generation and Survival
Emma de Pater; Polynikis Kaimakis; Chris S. Vink; Tomomasa Yokomizo; Tomoko Yamada-Inagawa; Reinier van der Linden; Parham Solaimani Kartalaei; Sally A. Camper; Nancy Speck; Elaine Dzierzak;
Journal of Experimental Medicine,
Volume 210, Issue 13, pp. 2843--2850, December 2013. DOI: 10.1084/jem.20130751
document
Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells
Michael J. Chen; Yan Li; Maria Elena De Obaldia; Qi Yang; Amanda D. Yzaguirre; Tomoko Yamada-Inagawa; Chris S. Vink; Avinash Bhandoola; Elaine Dzierzak; Nancy A. Speck;
Cell Stem Cell,
Volume 9, Issue 6, pp. 541--552, December 2011. DOI: 10.1016/j.stem.2011.10.003
document
Alternative Runx1 Promoter Usage in Mouse Developmental Hematopoiesis
Thomas Bee; Kate Liddiard; Gemma Swiers; Sorrel R.B. Bickley; Chris S. Vink; Andrew Jarratt; Jim R. Hughes; Alexander Medvinsky; Marella F.T.R. de Bruijn;
Blood Cells, Molecules, and Diseases,
Volume 43, Issue 1, pp. 35--42, July 2009. DOI: 10.1016/j.bcmd.2009.03.011
document

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Last updated: 31 Jan 2024

dr. C.S. Vink

Biography

Publications

BibTeX support

Chris Vink