Delft Bioengineering Institute awards Tiago Costa and Massimo Mastrangeli with 20KEUR grants

Dr. Tiago Costa (BE) and Dr. Massimo Mastrangeli (ECTM) have been awarded grants of 20KEUR by the Delft Bioengineering Institute (BEI) to pursue their research projects on ultrasound-based regeneration of neuronal circuits and medical implants to investigate cell mechanobiology, respectively.
Their multidisciplinary project proposals, conceived to bridge expertise among different departments within TU Delft, are among the 5 selected for the grants out of the 13 total submissions received by the BEI in response to their first call for proposals.
The projects will be run respectively in collaboration with Dr. Dimphna Meijer (TNW/BN) and Dr. Mohammad J. Mirzaali (3mE/BM).
Below are short summaries of the projects.

Regenerating neuronal circuits using ultrasound

People suffering from neurodegenerative disorders such as Alzheimer’s, Parkinson’s Disease and Multiple Sclerosis, have impaired neuronal circuits. Generation of new neuronal circuits by using a patient’s own stem cells may prove helpful in treating the disease. One of the difficulties in inducing neurons from stem cells, is the low efficiency rate we are able to achieve so far. In this project, BEI PIs Tiago Costa of Microelectronics (EWI) and Dimphna Meijer of Bionanoscience (TNW) join forces to explore the use of ultrasound for effectively building active neuronal networks from stem cells.

Project title: SoundCircuit: Regeneration of neuronal circuits using ultrasound
BEI PIs: Tiago Costa (EWI/ME), Dimphna Meijer (TNW/BN)

Medical implants to investigate cell mechanobiology

In order to study the cell’s behavior and differentiation, we need to be able to measure the mechanical, electrical, and biochemical signals that are dynamically transmitted throughout the cells. This requires the creation of biomaterial models equipped with different sensor types. In this project, BEI PIs Mohammad J. Mirzaali of Biomechanical Engineering (3mE) and Massimo Mastrangeli of Microelectronics (EWI) will team up to design, fabricate and test the proof-of-concept for medical implants equipped with force sensors that can reach a sensitivity level of one micronewton, so the mechanobiology of cells can be effectively investigated.

Project title: Sixth Sense Biomaterials
BEI PIs: Mohammad J. Mirzaali (3mE/BM), Massimo Mastrangeli (EWI/ME)

Read the full story on the TU Delft page.